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Matthias Beyens, Timon Vandamme, Marc Peeters, Guy Van Camp, and Ken Op de Beeck

tumor ( Daniel et al. 2009 , Cottu et al. 2014 , Ter Brugge et al. 2016 ). Since zebrafish ( Danio rerio ) embryos have highly conserved angiogenesis signaling compared to mammals, they often function as acceptor organism in the PDX approach

Open access

Laura C Hernández-Ramírez, Ryhem Gam, Nuria Valdés, Maya B Lodish, Nathan Pankratz, Aurelio Balsalobre, Yves Gauthier, Fabio R Faucz, Giampaolo Trivellin, Prashant Chittiboina, John Lane, Denise M Kay, Aggeliki Dimopoulos, Stephan Gaillard, Mario Neou, Jérôme Bertherat, Guillaume Assié, Chiara Villa, James L Mills, Jacques Drouin, and Constantine A Stratakis

embryogenesis, as inferred from in vitro studies and from the mouse and zebrafish models of gene inactivation ( Zukerberg et al. 2000 , Groeneweg et al. 2011 , Mizuno et al. 2014 ). CABLES1 is highly expressed in the nucleus of proliferating cells

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Arun Mouli Kolinjivadi, Siao Ting Chong, and Joanne Ngeow

rhythm that follow a 24-h periodicity governing the essential cellular and molecular events. Several landmark studies in mammals, zebrafish, plants, fungi and cyanobacteria support the concept of biological clock or circadian rhythm impacting different

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Giampaolo Trivellin, Fabio R Faucz, Adrian F Daly, Albert Beckers, and Constantine A Stratakis

elucidated how this GPCR is involved in the pathogenesis of this disease. To address this aspect, our groups are currently characterizing GPR101 transgenic and knockout mouse and zebrafish models. Moreover, there is no published data as yet that explain how

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Yu-Cheng Wang, Emerick Gallego-Arteche, Gioia Iezza, Xiaochen Yuan, Mary R Matli, Su-Pin Choo, Marlene B Zuraek, Ravi Gogia, Francis C Lynn, Michael S German, Emily K Bergsland, David B Donner, Robert S Warren, and Eric K Nakakura

differentiation in the central nervous system and pancreas ( Sussel et al . 1998 , Briscoe et al . 1999 , Cheng et al . 2003 , Craven et al . 2004 , Pattyn et al . 2004 ). A recent study showed that a transgenic zebrafish line with EGFP driven by the Nkx

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Ewan M Stephenson, Laura E J Usselmann, Vinay Tergaonkar, David M Virshup, and Robert Dallmann

) cells with BMAL1 k/d formed significantly smaller tumours when grafted onto zebrafish embryos than HCT116 WT. This model system is further removed from mammalian biology and it is unclear if this observation is a result of the cell type or the model

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Serisha Moodley, Frank Weber, and Lois M Mulligan

zebrafish and drosophila models to dissect RET signaling pathways and as important in vivo tools for screening novel therapeutics and studying their efficacy and mechanism of action. While research and therapeutic strategies have historically focused on

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Shuk-Mei Ho, Rahul Rao, Sarah To, Emma Schoch, and Pheruza Tarapore

of zebrafish to BPS during their development impaired their subsequent reproduction potential and hormonal balance when adult ( Naderi et al. 2014 ). BPS also disrupted membrane-initiated estradiol-induced cell signaling, leading to altered cell

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Ton van Agthoven, Anieta M Sieuwerts, Danielle Meijer, Marion E Meijer-van Gelder, Thecla L A van Agthoven, Roya Sarwari, Stefan Sleijfer, John A Foekens, and Lambert C J Dorssers

Reviews. Cancer 3 781 – 789 . Chakraborty A Uechi T Higa S Torihara H Kenmochi N 2009 Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response

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Benjamin Boyerinas, Sun-Mi Park, Annika Hau, Andrea E Murmann, and Marcus E Peter

WP Wienholds E Ketting RF Plasterk RH 2004 Substrate requirements for let-7 function in the developing zebrafish embryo . Nucleic Acids Research 32 6284 – 6291 . Kovalchuk O Filkowski J Meservy