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Fernand Labrie 2795 Laurier Boulevard Suite 500, Quebec City, Quebec, Canada G1V 4M7

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Introduction Prostate cancer is the most frequently diagnosed cancer and the second cause of cancer death in men in North America ( Siegel et al . 2013 ). In fact, one in eight men will be diagnosed with prostate cancer during his lifetime. At such

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Serk In Park Department of Periodontics and Oral Medicine, Department of Pathology, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, Michigan 48109, USA

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Laurie K McCauley Department of Periodontics and Oral Medicine, Department of Pathology, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, Michigan 48109, USA
Department of Periodontics and Oral Medicine, Department of Pathology, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, Michigan 48109, USA

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Introduction Prostate cancer is the second most frequently diagnosed cancer and the sixth leading cause of cancer-related death in males worldwide, notwithstanding the improved early detection methods and therapeutic modalities ( Jemal et al . 2011

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Simone de Brot Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

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Atara Ntekim Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

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Ryan Cardenas Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

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Victoria James Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

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Cinzia Allegrucci Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

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David M Heery Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

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David O Bates Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

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Niels Ødum Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

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Jenny L Persson Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

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Nigel P Mongan Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK
Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

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Prostate cancer: the molecular mechanisms of carcinogenesis and the role of androgens Prostate cancer (PCa) is the most common malignancy affecting western men ( Ferlay et al . 2013 , Siegel et al . 2015 ), and it is estimated to account for more

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Afaf Aldahish Pharmacology, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA

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Ajay Kale Pharmacology, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA

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Ahmed Aljameeli Pharmacology, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA

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Girish V Shah Pharmacology, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA

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Introduction Prostate cancer (PC) is the most frequently diagnosed cancer in men, exceeded only by lung cancer as the leading cause of cancer-related mortality among men ( Ferlay et al. 2010 ). Despite recent advances in the field, effective

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Antoinette S Perry
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Ruth Foley
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Karen Woodson
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Mark Lawler
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Introduction: addressing problems with the clinical management of prostate cancer Prostate cancer (CaP) has a unique set of problems associated with its early detection, diagnosis and treatment that might be aided by the

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Xinyu Wu Department of Pathology, Arthritis and Tissue Degeneration Program, Laboratory of Molecular Biology, Department of Pathology, Department of Urology, NYU Cancer Institute, New York Harbor Healthcare System, Department of Urology, New York University School of Medicine, New York, NY, USA

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Shiaoching Gong Department of Pathology, Arthritis and Tissue Degeneration Program, Laboratory of Molecular Biology, Department of Pathology, Department of Urology, NYU Cancer Institute, New York Harbor Healthcare System, Department of Urology, New York University School of Medicine, New York, NY, USA
Department of Pathology, Arthritis and Tissue Degeneration Program, Laboratory of Molecular Biology, Department of Pathology, Department of Urology, NYU Cancer Institute, New York Harbor Healthcare System, Department of Urology, New York University School of Medicine, New York, NY, USA

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Pradip Roy-Burman Department of Pathology, Arthritis and Tissue Degeneration Program, Laboratory of Molecular Biology, Department of Pathology, Department of Urology, NYU Cancer Institute, New York Harbor Healthcare System, Department of Urology, New York University School of Medicine, New York, NY, USA

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Peng Lee Department of Pathology, Arthritis and Tissue Degeneration Program, Laboratory of Molecular Biology, Department of Pathology, Department of Urology, NYU Cancer Institute, New York Harbor Healthcare System, Department of Urology, New York University School of Medicine, New York, NY, USA
Department of Pathology, Arthritis and Tissue Degeneration Program, Laboratory of Molecular Biology, Department of Pathology, Department of Urology, NYU Cancer Institute, New York Harbor Healthcare System, Department of Urology, New York University School of Medicine, New York, NY, USA
Department of Pathology, Arthritis and Tissue Degeneration Program, Laboratory of Molecular Biology, Department of Pathology, Department of Urology, NYU Cancer Institute, New York Harbor Healthcare System, Department of Urology, New York University School of Medicine, New York, NY, USA
Department of Pathology, Arthritis and Tissue Degeneration Program, Laboratory of Molecular Biology, Department of Pathology, Department of Urology, NYU Cancer Institute, New York Harbor Healthcare System, Department of Urology, New York University School of Medicine, New York, NY, USA

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Zoran Culig Department of Pathology, Arthritis and Tissue Degeneration Program, Laboratory of Molecular Biology, Department of Pathology, Department of Urology, NYU Cancer Institute, New York Harbor Healthcare System, Department of Urology, New York University School of Medicine, New York, NY, USA

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Introduction Prostate cancer (PCa) is the most common male-specific cancer in most western countries including the United States. An important cause of morbidity and mortality in PCa is skeletal metastasis; the pathogenesis of bone metastasis is

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Jason M D'Antonio Department of Urology, Department of Oncology, Brady Urologic Institute
Department of Urology, Department of Oncology, Brady Urologic Institute

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Donald J Vander Griend Department of Urology, Department of Oncology, Brady Urologic Institute
Department of Urology, Department of Oncology, Brady Urologic Institute

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John T Isaacs Department of Urology, Department of Oncology, Brady Urologic Institute
Department of Urology, Department of Oncology, Brady Urologic Institute

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Introduction Over the last several decades, there have been improvements in prostate cancer diagnosis and treatment primarily due to the diagnostic/prognostic use of prostate specific antigen, the advent of nerve sparing radical prostatectomy

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Eiji Kashiwagi Departments of ce:sup loc="post">1Urology, Clinical Chemistry and Laboratory Medicine

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Masaki Shiota Departments of ce:sup loc="post">1Urology, Clinical Chemistry and Laboratory Medicine

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Akira Yokomizo Departments of ce:sup loc="post">1Urology, Clinical Chemistry and Laboratory Medicine

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Momoe Itsumi Departments of ce:sup loc="post">1Urology, Clinical Chemistry and Laboratory Medicine

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Junichi Inokuchi Departments of ce:sup loc="post">1Urology, Clinical Chemistry and Laboratory Medicine

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Takeshi Uchiumi Departments of ce:sup loc="post">1Urology, Clinical Chemistry and Laboratory Medicine

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Seiji Naito Departments of ce:sup loc="post">1Urology, Clinical Chemistry and Laboratory Medicine

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Introduction Prostate cancer is the most commonly diagnosed non-skin cancer among men in developed countries ( Jemal et al . 2008 ). In its early stages, prostate cancer cell growth is androgen dependent, and androgen deprivation therapies cause

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Muhammed H Rahaman
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Malika Kumarasiri
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Laychiluh B Mekonnen Centre for Drug Discovery and Development, Sansom Institute for Health Research and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia

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Mingfeng Yu Centre for Drug Discovery and Development, Sansom Institute for Health Research and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia

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Sarah Diab Centre for Drug Discovery and Development, Sansom Institute for Health Research and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia

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Hugo Albrecht Centre for Drug Discovery and Development, Sansom Institute for Health Research and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia

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Robert W Milne Centre for Drug Discovery and Development, Sansom Institute for Health Research and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia

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Shudong Wang Centre for Drug Discovery and Development, Sansom Institute for Health Research and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia

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Introduction Prostate cancer (PCa) is the most common cancer diagnosed in men and is considered as one of the major causes of death in developed countries ( Siegel et al. 2015 ). It is highly prevalent in older men, with those over 65 years

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Shu Feng Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Irina U Agoulnik Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Anne Truong Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Zhen Li Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Chad J Creighton Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Elena M Kaftanovskaya Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Rhea Pereira Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Hee Dong Han Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Gabriel Lopez-Berestein Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Thomas Klonisch Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Michael M Ittmann Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Anil K Sood Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Alexander I Agoulnik Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Obstetrics and Gynecology, Department of Pathology and Immunology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Departments of Gynecologic Oncology and Cancer Biology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, Department of Human Anatomy and Cell Science, Michael E DeBakey Veterans Affairs Medical Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA

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Introduction Prostate cancer is the most common type of cancer in men in the United States and the second leading cause of cancer deaths. Androgens play a key role in prostate cancer initiation and progression and androgen ablation is initially

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