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Eva Baxter
Eva Baxter
Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
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Karolina Windloch
Karolina Windloch
Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
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Greg Kelly
Greg Kelly
Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
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Jason S Lee
Jason S Lee
Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
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Frank Gannon
Frank Gannon
Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
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Donal J Brennan
Donal J Brennan
UCD School of Medicine, Catherine McAuley Research Centre, Mater Misericordiae University Hospital, Dublin, Ireland
Cancer Biology and Therapeutics Laboratory, UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland
Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland
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Cancer Biology and Therapeutics Laboratory, UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland
Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland
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), SMAD3 (Abcam, ab28379), SMAD3 phospho-Ser423/425 (Abcam, ab52903) and XBP1 (Abcam, ab198999). Mouse xenograft model Six-to-seven-week-old female C.B. 17- SCID mice (Animal Resources Centre, Perth, Australia) either had a 0.72mg/pellet 90-day
Joanna E Burdette
Joanna E Burdette
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Teresa K Woodruff
Teresa K Woodruff
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Smad3 and this causes a redistribution of the cell cycle into G 0 /G 1 arrest ( Liu et al. 1996 , Ying & Zhang 1996 , Cocolakis et al. 2001 , Burdette et al. 2005 ). Activins A and B reduce proliferation of cultured rat acini isolated during
David Adler
David Adler
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Anne Offermann
Anne Offermann
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Martin Braun
Martin Braun
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Roopika Menon
Roopika Menon
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Isabella Syring
Isabella Syring
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Michael Nowak
Michael Nowak
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Rebecca Halbach
Rebecca Halbach
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Wenzel Vogel
Wenzel Vogel
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Christian Ruiz
Christian Ruiz
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Tobias Zellweger
Tobias Zellweger
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Cyrill A Rentsch
Cyrill A Rentsch
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Maria Svensson
Maria Svensson
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Ove Andren
Ove Andren
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Lukas Bubendorf
Lukas Bubendorf
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Saskia Biskup
Saskia Biskup
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Stefan Duensing
Stefan Duensing
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Jutta Kirfel
Jutta Kirfel
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Sven Perner
Sven Perner
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research
Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Institute for Pathology University Hospital Basel, Basel, Switzerland
Department of Urology St. Claraspital, Basel, Switzerland
Department of Urology University Hospital Basel, Basel, Switzerland
Department of Urology University Hospital of Örebro, Örebro, Sweden
School of Health and Medical Sciences Örebro University, Örebro, Sweden
Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany
Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany
Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
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-phospho (S423+S425)-SMAD3 rabbit MAB (1:1000, EP823Y, Abcam, Cambridge, UK), anti-β-actin MAB (1:5000, A1978, Sigma Aldrich, St Louis, MO, USA), and anti-Vimentin rabbit monoclonal (1:1000, 3932, Cell Signaling) primary antibodies at 4 °C overnight. The
Eric Glasgow
Eric Glasgow
Laboratory of Cancer Genetics, Veterans Affairs Medical Center, Digestive Diseases, and GI Developmental Biology, Department of Surgery, Medicine and Lombardi Cancer Center, Georgetown University Medical Center, Medical/Dental Building, NW 213, 3900 Reservoir Road, NW, Washington, District of Columbia 20007, USA
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Lopa Mishra
Lopa Mishra
Laboratory of Cancer Genetics, Veterans Affairs Medical Center, Digestive Diseases, and GI Developmental Biology, Department of Surgery, Medicine and Lombardi Cancer Center, Georgetown University Medical Center, Medical/Dental Building, NW 213, 3900 Reservoir Road, NW, Washington, District of Columbia 20007, USA
Laboratory of Cancer Genetics, Veterans Affairs Medical Center, Digestive Diseases, and GI Developmental Biology, Department of Surgery, Medicine and Lombardi Cancer Center, Georgetown University Medical Center, Medical/Dental Building, NW 213, 3900 Reservoir Road, NW, Washington, District of Columbia 20007, USA
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Laboratory of Cancer Genetics, Veterans Affairs Medical Center, Digestive Diseases, and GI Developmental Biology, Department of Surgery, Medicine and Lombardi Cancer Center, Georgetown University Medical Center, Medical/Dental Building, NW 213, 3900 Reservoir Road, NW, Washington, District of Columbia 20007, USA
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) falling into three functional classes: i) receptor-activated Smads (R-Smads): Smad1, Smad2, Smad3, Smad5, and Smad8; ii) co-mediator Smads: Smad4 and Smad 10; and iii) inhibitory Smads (I-Smads): Smad6 and Smad7. Activation of the TGF-β receptor complex by
Christina Schug
Christina Schug
Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany
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Sarah Urnauer
Sarah Urnauer
Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany
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Carsten Jaeckel
Carsten Jaeckel
Clinical Biochemistry Group, Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany
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Kathrin A Schmohl
Kathrin A Schmohl
Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany
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Mariella Tutter
Mariella Tutter
Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany
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Katja Steiger
Katja Steiger
Institute of Pathology, Klinikum Rechts der Isar der Technischen Universitaet Muenchen, Munich, Germany
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Nathalie Schwenk
Nathalie Schwenk
Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany
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Markus Schwaiger
Markus Schwaiger
Department of Nuclear Medicine, Klinikum Rechts der Isar der Technischen Universitaet Muenchen, Munich, Germany
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Ernst Wagner
Ernst Wagner
Department of Pharmacy, Center of Drug Research, Pharmaceutical Biotechnology, LMU Munich, Munich, Germany
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Peter J Nelson
Peter J Nelson
Clinical Biochemistry Group, Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany
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Christine Spitzweg
Christine Spitzweg
Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany
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. 1994 , Massague 1998 , Derynck et al. 2001 ). Activated SMAD2 and SMAD3 form heterotrimeric complexes with the signal mediator SMAD4. The complex translocates to the nucleus to modulate transcription of target genes. Inhibitory SMADs, such as SMAD6
Meng-Lei Zhu
Meng-Lei Zhu
Departments of Urology and Toxicology, University of Kentucky College of Medicine, University of Kentucky Medical Center, Combs Research Building Room 306, Lexington, Kentucky 40536, USA
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Natasha Kyprianou
Natasha Kyprianou
Departments of Urology and Toxicology, University of Kentucky College of Medicine, University of Kentucky Medical Center, Combs Research Building Room 306, Lexington, Kentucky 40536, USA
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subsequent phosphorylation of TGFBR2 receptor to the TGFBR1 kinase to SMAD activation ( Zhu & Kyprianou 2005 ). Interaction of SMAD4, (alone or together with SMAD3), with the AR in the DNA-binding and ligand-binding domains, may result in the modulation of
Xiao-Hua Jiang
Xiao-Hua Jiang
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Jie-Li Lu
Jie-Li Lu
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Bin Cui
Bin Cui
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Yong-Ju Zhao
Yong-Ju Zhao
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Wei-qing Wang
Wei-qing Wang
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Jian-Min Liu
Jian-Min Liu
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Wen-Qiang Fang
Wen-Qiang Fang
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Ya-Nan Cao
Ya-Nan Cao
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Yan Ge
Yan Ge
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Chang-xian Zhang
Chang-xian Zhang
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Huguette Casse
Huguette Casse
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Xiao-Ying Li
Xiao-Ying Li
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Guang Ning
Guang Ning
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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interacting domain for Smad3 binding, possibly affects Smad3 signalling ( Kaji et al . 2001 ), which is a crucial player in transforming growth factor-β (TGF-β) signalling pathway. In vitro study has confirmed that amino acid substitution in Smad3-binding
Nader Hussein
Nader Hussein
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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JieLi Lu
JieLi Lu
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Huguette Casse
Huguette Casse
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Sandra Fontanière
Sandra Fontanière
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Anne-Marie Morera
Anne-Marie Morera
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Séverine Mazaud Guittot
Séverine Mazaud Guittot
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Alain Calender
Alain Calender
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Nathalie Di Clemente
Nathalie Di Clemente
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Chang X Zhang
Chang X Zhang
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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. 2003 a ), using antibodies against menin (C19, 1:500), anti-p18 (1:3000), anti-p27 (1:1000), anti-pSmad1 (1:1000), anti-Smad1 (1:1000), anti-Smad3 (1:1000), anti-Smad4 (1:1000), anti-Smad5 polyclonal (1:1000) and anti-Cdk4 (1:1000, Santa
Sonia D'Inzeo
Sonia D'Inzeo
Departments of, Experimental Medicine, Molecular Medicine, Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
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Arianna Nicolussi
Arianna Nicolussi
Departments of, Experimental Medicine, Molecular Medicine, Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
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Caterina Francesca Donini
Caterina Francesca Donini
Departments of, Experimental Medicine, Molecular Medicine, Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
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Massimo Zani
Massimo Zani
Departments of, Experimental Medicine, Molecular Medicine, Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
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Patrizia Mancini
Patrizia Mancini
Departments of, Experimental Medicine, Molecular Medicine, Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
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Francesco Nardi
Francesco Nardi
Departments of, Experimental Medicine, Molecular Medicine, Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
Departments of, Experimental Medicine, Molecular Medicine, Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
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Departments of, Experimental Medicine, Molecular Medicine, Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
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Anna Coppa
Anna Coppa
Departments of, Experimental Medicine, Molecular Medicine, Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
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1998 ). TGFβ ligands bind to heterotetrameric complexes of receptors with serine–threonine kinase activity, leading to an increase in their ability to phosphorylate receptor-regulated Smads (R-Smads). The phosphorylation of R-Smads (Smad2 and Smad3) by
R Serra
R Serra
Department of Cell Biology, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, USA
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M R Crowley
M R Crowley
Department of Cell Biology, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, USA
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-β signaling is integrated with signaling from other growth factors ( Zhang & Derynck 1999 , Attisano & Wrana 2000 , Massague & Chen 2000 ). Specific R-Smads transduce distinct signals for members of the TGF-β superfamily. Smad2 and Smad3 mediate signaling by
