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Konsta Kukkonen Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Bryn Autio-Kimura Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Hanna Rauhala Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Juha Kesseli Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Matti Nykter Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
Foundation for the Finnish Cancer Institute, Helsinki, Finland

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Leena Latonen Foundation for the Finnish Cancer Institute, Helsinki, Finland
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

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Tapio Visakorpi Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
Fimlab Laboratories Ltd, Tampere, Finland

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on the gene expression changes related to the activation of AR using our RNA-seq dataset. First, we used unsupervised hierarchical clustering of the HALLMARK ANDROGEN RESPONSE gene set to cluster the cell lines based on their transcriptional response

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0108
Volume/Issue:
Volume 29: Issue 12
Open access
S Darby
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J Stockley
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M M Khan
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C N Robson
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H Y Leung
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V J Gnanapragasam
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full promoter activity (acting as an enhancer). Our analysis of the sequence proximal to the ATG revealed a putative androgen response element (ARE) which is further upstream of this minimal promoter region. We have previously observed a similar

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0041
Volume/Issue:
Volume 14: Issue 3
Free access
Garrett Daniels Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Yirong Li Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Lan Lin Gellert Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Albert Zhou Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Jonathan Melamed Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Xinyu Wu Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Xinming Zhang Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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David Zhang Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Daniel Meruelo Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Susan K Logan Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Ross Basch Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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Peng Lee Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA

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factors that plays an important role in the regulation of genes controlling growth suppression/differentiation and growth of prostate cells. Androgens activate AR, facilitating its translocation to the nucleus, binding at androgen-response elements (ARE

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0293
Volume/Issue:
Volume 21: Issue 1
Free access
Rosalinda M Savoy VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Liqun Chen VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Salma Siddiqui VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Frank U Melgoza VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Blythe Durbin-Johnson VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Christiana Drake VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Maitreyee K Jathal VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Swagata Bose VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Thomas M Steele VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Benjamin A Mooso VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Leandro S D'Abronzo VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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William H Fry VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Kermit L Carraway III VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Maria Mudryj VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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Paramita M Ghosh VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA
VA Northern California Health Care System, Department of Urology, Division of Biostatistics, Department of Statistics, Department of Biochemistry and Molecular Medicine, Department of Medical Microbiology and Immunology, Mather, California, USA

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the end of this article. Plasmids pCMV-FLNA, FLNA(16–24), and FLNA(1–15) plasmids were kindly provided by Dr E W Yong, National University of Singapore, Singapore, and human PSA-luciferase (hPSA-luc) construct containing two androgen response elements

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0021
Volume/Issue:
Volume 22: Issue 3
Free access
J-R Weng
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C-Y Chen
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J J Pinzone
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M D Ringel
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C-S Chen
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troglitazone at concentrations (≤10 μM) lower than that required for growth inhibition (≥20 μM) was able to down-regulate PSA expression in LNCaP prostate cancer cells through the inhibition of androgen activation of the androgen response elements in the

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.01182
Volume/Issue:
Volume 13: Issue 2
Free access
Lei Zhang
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Gregory J Barritt
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regulation of TRPM8 in androgen-responsive prostate cancer cells has been addressed, and several putative androgen response elements have been detected ( Zhang & Barritt 2004 , Bidaux et al. 2005 ). Analysis of 5′ flank regions of the TRPM8 gene using

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.01093
Volume/Issue:
Volume 13: Issue 1
Free access
Meng-Lei Zhu Departments of Urology and Toxicology, University of Kentucky College of Medicine, University of Kentucky Medical Center, Combs Research Building Room 306, Lexington, Kentucky 40536, USA

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Natasha Kyprianou Departments of Urology and Toxicology, University of Kentucky College of Medicine, University of Kentucky Medical Center, Combs Research Building Room 306, Lexington, Kentucky 40536, USA

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regulating the binding of endogenous HuR to the AU-rich 3′UTRs, e.g. EGF mRNA ( Myers et al . 1999 , Torring et al . 2003 ). The ability of androgens to regulate the expression of androgen response element (ARE)-binding proteins that bind to these

Article Type:
Review Article
DOI:
https://doi.org/10.1677/ERC-08-0084
Volume/Issue:
Volume 15: Issue 4
Free access
Zhi Long Department of Urology, Third Xiangya Hospital, Institute of Prostate Disease, Central South University, Changsha, China
Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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Yinan Li Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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Yu Gan Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada
Department of Urology, Xiangya Hospital, Central South University, Changsha, China

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Dongyu Zhao Center for Bioinformatics and Computational Biology, Houston Methodist Research Institute, Houston, Texas, USA
Department of Cardiothoracic Surgeries, Weill Cornell Medical College, Cornell University, New York, New York, USA
Institute for Academic Medicine, Houston Methodist Hospital, Houston, Texas, USA

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Guangyu Wang Center for Bioinformatics and Computational Biology, Houston Methodist Research Institute, Houston, Texas, USA
Department of Cardiothoracic Surgeries, Weill Cornell Medical College, Cornell University, New York, New York, USA
Institute for Academic Medicine, Houston Methodist Hospital, Houston, Texas, USA

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Ning Xie Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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Jessica M Lovnicki Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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Ladan Fazli Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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Qi Cao Department of Urology and Robert H. Lurie Comprehensive Cancer Cancer, Northwestern University Reinberg School of Medicine, Chicago, Illinois, USA

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Kaifu Chen Center for Bioinformatics and Computational Biology, Houston Methodist Research Institute, Houston, Texas, USA
Department of Cardiothoracic Surgeries, Weill Cornell Medical College, Cornell University, New York, New York, USA
Institute for Academic Medicine, Houston Methodist Hospital, Houston, Texas, USA

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Xuesen Dong Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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lipid metabolism gene sets are highly suppressed by HOXA10 ( P  < 0.001) ( Fig. 4B ). Additionally, androgen response genes were also inhibited ( Fig. 4C ). Together, these results revealed an association of HOXA10 with both cell lipid metabolism and the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0465
Volume/Issue:
Volume 26: Issue 3
Free access
Sangeeta Kumari Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA

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Dhirodatta Senapati Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA

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Hannelore V Heemers Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA
Department of Urology, Cleveland Clinic, Cleveland, Ohio, USA
Department of Hematology/Medical Oncology, Cleveland Clinic, Cleveland, Ohio, USA

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undergo conformational changes, alter its association with chaperones and translocate to the nucleus. Inside the nucleus, ligand-bound AR binds to DNA recognition motifs known as androgen response elements (AREs) and recruits from a large array of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0121
Volume/Issue:
Volume 24: Issue 8
Free access
Zsofia Kiss VA Northern California Health Care System, Mather, California, USA
Department of Urology, University of California at Davis, Sacramento, California, USA

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Paramita M Ghosh VA Northern California Health Care System, Mather, California, USA
Department of Urology, University of California at Davis, Sacramento, California, USA
Department of Biochemistry and Molecular Medicine, University of California at Davis, Sacramento, California, USA

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protein complex and is allowed to move to the nucleus, binding target genes through their androgen response elements located in the promoter or enhancer regions. Many of the genes targeted by the AR are involved in the growth and survival of prostate cells

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0366
Volume/Issue:
Volume 23: Issue 11
Free access