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Andrea Weckman Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Fabio Rotondo Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Michael D Cusimano Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Kalman Kovacs Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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autophagy modulation Type of cancer Therapy Independent effect on autophagy? Combinatorial effect with autophagy-targeted drugs? Inhibition or enhancement of autophagy as target? Spontaneous pituitary adenomas Acrylonitrile ( Kamijo et al . 1986 ) Yes

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Shani Avniel-Polak Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Gil Leibowitz Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Victoria Doviner Department of Pathology, Shaare Zedek Medical Center, Jerusalem, Israel

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David J Gross Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Autophagy modulation as a potential therapeutic target for diverse diseases . Nature Reviews Drug Discovery 11 709 – 730 . ( https://doi.org/10.1038/nrd3802 ) 22935804 10.1038/nrd3802 Seitz C Hugle M Cristofanon S Tchoghandjian A Fulda S 2013 The

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Justin S Gundara Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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JingTing Zhao Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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Bruce G Robinson Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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Stan B Sidhu Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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Cellular Biochemistry 111 1426 – 1436 . ( doi:10.1002/jcb.22869 ). White E DiPaola R 2009 The double-edged sword of autophagy modulation in cancer . Clinical Cancer Research 15 5308 – 5316 . ( doi:10.1158/1078-0432.CCR-07-5023 ). White E

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Federica Morani Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Rossella Titone Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Loredana Pagano Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Alessandra Galetto Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Oscar Alabiso Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Gianluca Aimaretti Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Ciro Isidoro Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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The double-edged sword of autophagy modulation in cancer . Clinical Cancer Research 15 5308 – 5316 . ( doi:10.1158/1078-0432.CCR-07-5023 ). Won KY Kim GY Lim SJ Kim YW 2012 Decreased Beclin-1 expression is correlated with the growth of the primary

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Andrea Nicolini Department of Oncology, Transplantations and New Technologies in Medicine, University of Pisa, Pisa, Italy

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Paola Ferrari Department of Oncology, Transplantations and New Technologies in Medicine, University of Pisa, Pisa, Italy

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Giuseppe Rossi Unit of Epidemiology and Biostatistics, Institute of Clinical Physiology, National Council of Research, Pisa, Italy

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Angelo Carpi Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Autophagy modulation in cancer: current knowledge on action and therapy . Oxidative Medicine and Cellular Longevity 2018 8023821 . ( https://doi.org/10.1155/2018/8023821 ) 29643976 Markosyan N Chen EP Evans RA Ndong V Vonderheide RH Smyth EM 2013

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