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Deborah J Thompson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tracy A O'Mara Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Dylan M Glubb Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jodie N Painter Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Timothy Cheng Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Elizabeth Folkerd Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Deborah Doody Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Joe Dennis Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Penelope M Webb Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the Australian National Endometrial Cancer Study Group (ANECS) Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Maggie Gorman Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Lynn Martin Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Shirley Hodgson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the National Study of Endometrial Cancer Genetics Group (NSECG) Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kyriaki Michailidou Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jonathan P Tyrer Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mel J Maranian Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Per Hall Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kamila Czene Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hatef Darabi Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jingmei Li Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Peter A Fasching Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alexander Hein Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias W Beckmann Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Arif B Ekici Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Thilo Dörk Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Peter Hillemanns Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias Dürst Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ingo Runnebaum Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hui Zhao Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jeroen Depreeuw Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stefanie Schrauwen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Frederic Amant Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ellen L Goode Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Brooke L Fridley Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Sean C Dowdy Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stacey J Winham Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Helga B Salvesen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jone Trovik Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tormund S Njolstad Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Henrica M J Werner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Katie Ashton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tony Proietto Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Geoffrey Otton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Luis Carvajal-Carmona Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Emma Tham Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tao Liu Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Miriam Mints Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for RENDOCAS Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Rodney J Scott Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mark McEvoy Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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John Attia Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Elizabeth G Holliday Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Grant W Montgomery Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Nicholas G Martin Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Dale R Nyholt Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Anjali K Henders Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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John L Hopper Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Nadia Traficante Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the AOCS Group Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias Ruebner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Anthony J Swerdlow Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Barbara Burwinkel Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hermann Brenner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alfons Meindl Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hiltrud Brauch Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Annika Lindblom Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Diether Lambrechts Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jenny Chang-Claude Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Fergus J Couch Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Graham G Giles Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Vessela N Kristensen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Angela Cox Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Manjeet K Bolla Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Qin Wang Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stig E Bojesen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mitul Shah Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Robert Luben Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kay-Tee Khaw Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Paul D P Pharoah Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alison M Dunning Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ian Tomlinson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mitch Dowsett Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Douglas F Easton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Amanda B Spurdle Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Introduction Established risk factors for endometrial cancer include high BMI ( IARC 2002 ), early menarche, late menopause, nulliparity, estrogen-only hormone replacement therapy (HRT) ( Beral et al . 2005 ) and tamoxifen use ( Cuzick et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0386
Volume/Issue:
Volume 23: Issue 2
Open access
Tracy A O'Mara Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Dylan M Glubb Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jodie N Painter Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Timothy Cheng Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Joe Dennis Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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The Australian National Endometrial Cancer Study Group (ANECS) Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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John Attia Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Elizabeth G Holliday Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Mark McEvoy Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Rodney J Scott Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Katie Ashton Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Tony Proietto Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Geoffrey Otton Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Mitul Shah Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Shahana Ahmed Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Catherine S Healey Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Maggie Gorman Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Lynn Martin Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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National Study of Endometrial Cancer Genetics Group (NSECG) Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Shirley Hodgson Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Peter A Fasching Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Alexander Hein Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Matthias W Beckmann Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Arif B Ekici Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Per Hall Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Kamila Czene Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hatef Darabi Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jingmei Li Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Matthias Dürst Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Ingo Runnebaum Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Peter Hillemanns Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Thilo Dörk Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Diether Lambrechts Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jeroen Depreeuw Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Daniela Annibali Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Frederic Amant Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hui Zhao Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Ellen L Goode Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Sean C Dowdy Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Brooke L Fridley Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Stacey J Winham Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Helga B Salvesen Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Tormund S Njølstad Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jone Trovik Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Henrica M J Werner Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Emma Tham Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Tao Liu Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Miriam Mints Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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RENDOCAS Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Manjeet K Bolla Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Kyriaki Michailidou Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jonathan P Tyrer Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Qin Wang Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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John L Hopper Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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AOCS Group Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Julian Peto Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Anthony J Swerdlow Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Barbara Burwinkel Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hermann Brenner Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Alfons Meindl Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hiltrud Brauch Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Annika Lindblom Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jenny Chang-Claude Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Fergus J Couch Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Graham G Giles Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Vessela N Kristensen Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Angela Cox Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Paul D P Pharoah Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Alison M Dunning Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Ian Tomlinson Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Douglas F Easton Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Deborah J Thompson Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Amanda B Spurdle Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Introduction Endometrial cancer is the most commonly diagnosed gynaecological malignancy in developed countries ( http://globocan.iarc.fr/ ). Excessive endogenous and exogenous estrogen exposure or estrogen exposure unopposed by progesterone

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https://doi.org/10.1530/ERC-15-0319
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Serpil Erdogan
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Sevilay Sezer
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Eralp Baser Department of Clinical Biochemistry, Department of Gynecologic Oncology, Numune Training and Research Hospital, Ankara, Turkey

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Ozlem Gun-Eryilmaz Department of Clinical Biochemistry, Department of Gynecologic Oncology, Numune Training and Research Hospital, Ankara, Turkey

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Tayfun Gungor Department of Clinical Biochemistry, Department of Gynecologic Oncology, Numune Training and Research Hospital, Ankara, Turkey

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Sema Uysal
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Fatma Meric Yilmaz
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almost 1600 deaths per day. Corporal uterine cancer, which is the most commonly diagnosed gynecological cancer, is responsible for the death of one fifth of women with endometrial cancer ( Siegel et al . 2013 ). The prevailing theory regarding the

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https://doi.org/10.1530/ERC-13-0280
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Jianguang Ji
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Asta Fôrsti
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Jan Sundquist
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Kari Hemminki
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-binding globulin after twin pregnancy ( Thomas et al. 1998 , Hall 2003 ). These changes may influence the occurrence of hormone responsive cancers, such as breast, endometrial, and ovarian cancers ( Neale et al. 2004 , 2005 a , Neale et al. b ). A slightly

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https://doi.org/10.1677/ERC-07-0088
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Volume 14: Issue 3
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Parvesh Chaudhry Research Group in Molecular Oncology and Endocrinology, Canada Research Chair in Molecular Gyneco-Oncology, Department of Chemistry Biology, University of Quebec at Trois-Rivieres, 3351, Boulevard des Forges, CP 500, Trois-Rivieres, Québec, Canada G9A 5H7

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Eric Asselin Research Group in Molecular Oncology and Endocrinology, Canada Research Chair in Molecular Gyneco-Oncology, Department of Chemistry Biology, University of Quebec at Trois-Rivieres, 3351, Boulevard des Forges, CP 500, Trois-Rivieres, Québec, Canada G9A 5H7

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Introduction Endometrial cancer represents the most common gynecological malignancy in the western world. While early-stage endometrial cancer has favorable prognosis, advanced or recurrent disease presents a major hurdle. Chemotherapy and hormonal

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https://doi.org/10.1677/ERC-08-0266
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Volume 16: Issue 2
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Douglas A Gibson MRC Centre for Reproductive Health The University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Ioannis Simitsidellis MRC Centre for Reproductive Health The University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Frances Collins MRC Centre for Reproductive Health The University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Philippa T K Saunders MRC Centre for Reproductive Health The University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Introduction Endometrial cancer (EC) and ovarian cancer are common gynaecological malignancies; however, the impact of androgen action in these cancers is poorly understood. Epidemiological evidence suggests that androgens may be important in the

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https://doi.org/10.1530/ERC-13-0551
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Alfred O Mueck Department of Endocrinology and Menopause, Centre for Women's Health BW, University Women's Hospital, Calwer Strasse 7, D-72076 Tuebingen, Germany

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Harald Seeger Department of Endocrinology and Menopause, Centre for Women's Health BW, University Women's Hospital, Calwer Strasse 7, D-72076 Tuebingen, Germany

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Thomas Rabe Department of Endocrinology and Menopause, Centre for Women's Health BW, University Women's Hospital, Calwer Strasse 7, D-72076 Tuebingen, Germany

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Introduction Two different clinicopathological subtypes of endometrial cancer are recognized: estrogen-related type 1 (endometroid), comprising 70–80% of newly diagnosed cancer, and nonestrogen-related type 2 (nonendometroid such as papillary serous

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Eva Baxter Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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Karolina Windloch Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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Greg Kelly Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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Jason S Lee Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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Frank Gannon Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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Donal J Brennan UCD School of Medicine, Catherine McAuley Research Centre, Mater Misericordiae University Hospital, Dublin, Ireland
Cancer Biology and Therapeutics Laboratory, UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland
Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

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transcription ( Frasor et al. 2003 , Laganière et al. 2005 , Carroll et al. 2006 ). Although anti-oestrogens are a key component of systemic breast cancer treatment, they are not routinely used in endometrial cancer due to lack of proven efficacy

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Mitsuyo Matsumoto Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan
Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan

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Yuri Yamaguchi Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan

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Yuko Seino Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan

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Atsushi Hatakeyama Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan

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Hiroyuki Takei Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan

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Hitoshi Niikura Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan

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Kiyoshi Ito Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan

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Takashi Suzuki Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan

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Hironobu Sasano Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan

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Nobuo Yaegashi Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan

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Shin-ichi Hayashi Departments of, Medical Technology, Obstetrics and Gynecology, Pathology, Research Institute for Clinical Oncology, Division of Breast Surgery, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 981-0872, Japan

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Introduction Endometrial carcinoma (EC) is one of the most common gynecological cancers found in women worldwide ( Landis et al . 1999 ). Estrogen contributes to endometrial carcinogenesis ( Hecht & Mutter 2006 , Ito 2007 ) and malignant

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https://doi.org/10.1677/ERC-07-0227
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Laura M S Seeber
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Ronald P Zweemer
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Luigi Marchionni Department of Gynaecological Oncology, Department of Oncology, Department of Obstetrics and Gynaecology (791), Department of Pathology, Department of Gynaecological Oncology, Department of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands

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Leon F A G Massuger Department of Gynaecological Oncology, Department of Oncology, Department of Obstetrics and Gynaecology (791), Department of Pathology, Department of Gynaecological Oncology, Department of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands

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Vincent T H B M Smit Department of Gynaecological Oncology, Department of Oncology, Department of Obstetrics and Gynaecology (791), Department of Pathology, Department of Gynaecological Oncology, Department of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands

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W Marchien van Baal Department of Gynaecological Oncology, Department of Oncology, Department of Obstetrics and Gynaecology (791), Department of Pathology, Department of Gynaecological Oncology, Department of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands

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René H M Verheijen
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Paul J van Diest Department of Gynaecological Oncology, Department of Oncology, Department of Obstetrics and Gynaecology (791), Department of Pathology, Department of Gynaecological Oncology, Department of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands

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methylation patterns may provide a useful signature for tumour diagnosis and may be used to assess prognosis. In the Western world, endometrial cancer is the most common malignant tumour of the female genital tract. The American Cancer Society estimates that

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https://doi.org/10.1677/ERC-10-0014
Volume/Issue:
Volume 17: Issue 3
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