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Yue Wang Liggins Institute, University of Auckland, Auckland, New Zealand
Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand

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Stephen M F Jamieson Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand
Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand
Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand

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Jo K Perry Liggins Institute, University of Auckland, Auckland, New Zealand
Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand

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provided by a feedback loop mechanism (+ and −), with high circulating GH and IGF1 inhibiting GH secretion. GH and IGF1 can also be expressed in extra-pituitary tissues and tumours, where they have local autocrine/paracrine actions on GHR- and IGF1R

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Cesar Luiz Boguszewski Department of Internal Medicine, Endocrine Division (SEMPR), University Hospital, Federal University of Parana, Curitiba, Brazil

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Margaret Cristina da Silva Boguszewski Department of Pediatrics, Endocrine Division (SEMPR), University Hospital, Federal University of Parana, Curitiba, Brazil

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Wouter W de Herder Department of Internal Medicine, Sector of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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(EPIC) study involving 141,896 men showed that those who were taller had an elevated risk of high-grade prostate cancer and prostate cancer death ( Perez-Cornago et al. 2017 ). In more recent years, the Mendelian randomization (MR) approach was

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Reetobrata Basu Edison Biotechnology Institute, Athens, Ohio, USA

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John J Kopchick Edison Biotechnology Institute, Athens, Ohio, USA
Molecular and Cellular Biology Program, Ohio University, Athens, Ohio, USA
Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA

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tract cancers ( Riesterer et al. 2011 ), nasopharyngeal carcinoma ( Wang et al. 2019 ), osteosarcoma ( Wang et al. 2009 ) and pediatric high-grade glioma ( Simpson et al. 2020 ). Therefore, GH and IGF1 are strongly implicated as a major

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Christopher A Galifi Department of Pharmacology, Physiology, & Neuroscience, Center for Cell Signaling and Cancer Institute of New Jersey, Rutgers Biomedical and Health Sciences, Newark, New Jersey, United States

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Teresa L Wood Department of Pharmacology, Physiology, & Neuroscience, Center for Cell Signaling and Cancer Institute of New Jersey, Rutgers Biomedical and Health Sciences, Newark, New Jersey, United States

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-positive breast cancer resistant to non-steroidal aromatase inhibitors 2 Terminated No data on primary outcome of progression-free survival rate; high frequency of low-grade GI distress and glucose intolerance Cixutumumab/A12 (with cisplatin and

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Vera Chesnokova Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

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Shlomo Melmed Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

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pituitary and npGH action may be explained by direct GH effects vs those mediated through IGF1, insulin, glucose, or free fatty acids, which are normally induced with GH increase ( Huang et al. 2022 ). Thus, high IGF1, but not GH, may activate cytokine

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Paul C Marker School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Christopher J Unterberger School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Steven M Swanson School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin, USA

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secretion. Male rats have a highly pulsatile secretion pattern of GH with high peak levels and low interpulse GH levels, whereas female rats have a lower peak amplitude and higher interpulse GH level, making GH secretion more continuous and less varying

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