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Judith A Gilbert Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Laura J Adhikari Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Ricardo V Lloyd Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Joseph Rubin Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Paul Haluska Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Joan M Carboni Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Marco M Gottardis Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Matthew M Ames Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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immunohistochemical staining (intensity score of 3) for the ten molecular markers studied. Hsp90, TGFBR1, IGF1R, and SSTR5 (the strongest staining biomarkers for the largest number of NETs) were expressed in all tumors from 20 cases in which primary and metastatic

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0318
Volume/Issue:
Volume 17: Issue 3
Free access
Dermot O'Toole Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland
Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Anne Couvelard Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland
Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Vinciane Rebours Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Magali Zappa Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Olivia Hentic Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Pascal Hammel Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Philippe Levy Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Pierre Bedossa Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland
Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Eric Raymond Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Philippe Ruszniewski Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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aggressive GEP-NETs but their influence on therapy is unknown. Several putative molecular markers predicting either sensitivity or resistance to oncological therapeutics have been proposed. The multidrug resistance protein and other ABC transporters have well

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0204
Volume/Issue:
Volume 17: Issue 4
Free access
Susan J Hsiao Division of Molecular and Genomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA

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Yuri E Nikiforov Division of Molecular and Genomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA

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need for molecular markers The diagnosis of thyroid cancer is typically obtained through ultrasound examination and fine-needle aspiration (FNA) biopsy of suspicious nodules. Cytological examination of cells collected by FNA biopsy is the most reliable

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0166
Volume/Issue:
Volume 21: Issue 5
Free access
P J Barrett-Lee Cardiff Breast Unit, Velindre NHS Trust, Cardiff CF14 2 TL, UK

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other candidate markers for a way forward. Molecular markers for chemotherapy response At the present time, no single predictive biological marker has become established in routine practice in breast cancer to assess clinical

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01024
Volume/Issue:
Volume 12: Issue Supplement_1
Free access
Vincenzo Marotta IOS & COLEMAN Srl, Naples, Italy

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Concetta Sciammarella IOS & COLEMAN Srl, Naples, Italy

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Annamaria Colao Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

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Antongiulio Faggiano Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori-IRCCS “Fondazione G. Pascale”, Naples, Italy

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cytology. By contrast, application of molecular characterisation in the prognostic setting of DTC is still at a preliminary level. To date, any molecular marker has a well-defined role in the risk stratification of DTC, and the introduction of the so

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0372
Volume/Issue:
Volume 23: Issue 11
Free access
Ruth Foley Department of Haematology and Oncology, Institute of Molecular Medicine, St James’ Hospital, James’ St, Dublin 8, Ireland

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Donal Hollywood Department of Haematology and Oncology, Institute of Molecular Medicine, St James’ Hospital, James’ St, Dublin 8, Ireland

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Mark Lawler Department of Haematology and Oncology, Institute of Molecular Medicine, St James’ Hospital, James’ St, Dublin 8, Ireland

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mechanisms, including cross-activation by agents such as IGF-I ( Culig et al. 1994 ). Potential new molecular markers such as hepsin ( Rhodes et al. 2002 ) have been identified. These and other identified and novel genes implicated in the disease

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00699
Volume/Issue:
Volume 11: Issue 3
Free access
Marion T Weigel The Institute of Cancer Research, Royal Marsden Hospital, Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London SW3 6JB, UK

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Mitch Dowsett The Institute of Cancer Research, Royal Marsden Hospital, Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London SW3 6JB, UK
The Institute of Cancer Research, Royal Marsden Hospital, Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London SW3 6JB, UK

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because of a widely varying set of clinical reports. Given the development of new targeted molecular therapies, there will continue to be a need for identifying and devising new markers that will be able to predict for specific response. It will be a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0136
Volume/Issue:
Volume 17: Issue 4
Free access
Filomena Cetani University Hospital of Pisa, Unit of Endocrinology, Pisa, Italy

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Claudio Marcocci Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Liborio Torregrossa University Hospital of Pisa, Division of Surgical Pathology, Pisa, Italy

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Elena Pardi Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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parathyroid adenomas could represent an early stage of a parathyroid carcinoma, which is excised before the development of the molecular signature of malignancy responsible for invasive properties remains to be established. Immunohistochemical markers have

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0135
Volume/Issue:
Volume 26: Issue 7
Free access
S G Creemers Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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L J Hofland Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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E Korpershoek Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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G J H Franssen Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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F J van Kemenade Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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W W de Herder Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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R A Feelders Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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analyzed the discriminative value of the molecular markers were included in this overview. Total sensitivity and specificity represents a weighted mean Study ACC ( n ) ACA ( n ) Sens (%) Spec (%) Cutoff Reference diagnosis Comments IGF2 Gicquel et al

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0452
Volume/Issue:
Volume 23: Issue 1
Free access
Krzysztof Fujarewicz
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Michał Jarząb
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Markus Eszlinger
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Knut Krohn
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Ralf Paschke
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Małgorzata Oczko-Wojciechowska
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Małgorzata Wiench
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Aleksandra Kukulska
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Barbara Jarząb
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Andrzej Swierniak
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). Bootstrap-based multi-gene classification of PTC microarray data Selection of genes is an important goal of microarray studies contributing to broader understanding of the cancer transcriptome as well as yielding novel molecular cancer markers

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-06-0048
Volume/Issue:
Volume 14: Issue 3
Free access