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Département de Médecine Génomique des Tumeurs et des Cancers, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France
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Biomedical Research Networking Centre on Rare Diseases (CIBERER), Institute of Health Carlos III, Madrid, Spain
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Mays Cancer Center at UTHSCSA, San Antonio, Texas, USA
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delays caused by the COVID-19 pandemic. In the intervening years, two international meetings related to pheochromocytomas (PCC) and paragangliomas (PGL) took place, Multiple Endocrine Neoplasia Workshop 2019 (in Houston) and 2021 (virtual). In 2019, the
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Introduction Pituitary adenomas (PA) and phaeochromocytomas/paragangliomas (phaeo/PGL) are relatively rare tumours. The prevalence of symptomatic PA in the general population is around 1 in 1000 ( Daly et al . 2006 , Fernandez et al . 2010 ). The
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Introduction Phaeochromocytomas (PCs) are tumours in the adrenal medulla, and paragangliomas (PGLs) arise in extra-adrenal sympathetic chromaffin tissue or head and neck parasympathetic tissues. Familial occurrence of PGLs was first reported in 1933
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Introduction Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from chromaffin cells of the adrenal medulla and paraganglia, respectively ( Jimenez 2018 ). Each year, approximately 500–1600 new cases of PPGLs
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Department of Medical Imaging, CNRS, Department of Biophysics and Nuclear Medicine, ICube, Department of Otorhinolaryngology–Head and Neck Surgery, Department of Otorhinolaryngology–Head and Neck Surgery, Program in Reproductive and Adult Endocrinology, Department of Nuclear Medicine, Biophysics and Nuclear Medicine, INSERM, La Timone University Hospital, Aix‐Marseille University, Marseille, France
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Department of Medical Imaging, CNRS, Department of Biophysics and Nuclear Medicine, ICube, Department of Otorhinolaryngology–Head and Neck Surgery, Department of Otorhinolaryngology–Head and Neck Surgery, Program in Reproductive and Adult Endocrinology, Department of Nuclear Medicine, Biophysics and Nuclear Medicine, INSERM, La Timone University Hospital, Aix‐Marseille University, Marseille, France
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Department of Medical Imaging, CNRS, Department of Biophysics and Nuclear Medicine, ICube, Department of Otorhinolaryngology–Head and Neck Surgery, Department of Otorhinolaryngology–Head and Neck Surgery, Program in Reproductive and Adult Endocrinology, Department of Nuclear Medicine, Biophysics and Nuclear Medicine, INSERM, La Timone University Hospital, Aix‐Marseille University, Marseille, France
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Department of Medical Imaging, CNRS, Department of Biophysics and Nuclear Medicine, ICube, Department of Otorhinolaryngology–Head and Neck Surgery, Department of Otorhinolaryngology–Head and Neck Surgery, Program in Reproductive and Adult Endocrinology, Department of Nuclear Medicine, Biophysics and Nuclear Medicine, INSERM, La Timone University Hospital, Aix‐Marseille University, Marseille, France
Department of Medical Imaging, CNRS, Department of Biophysics and Nuclear Medicine, ICube, Department of Otorhinolaryngology–Head and Neck Surgery, Department of Otorhinolaryngology–Head and Neck Surgery, Program in Reproductive and Adult Endocrinology, Department of Nuclear Medicine, Biophysics and Nuclear Medicine, INSERM, La Timone University Hospital, Aix‐Marseille University, Marseille, France
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Introduction Paragangliomas (PGLs) are slow-growing hypervascular tumors arising from neural crest cell derivatives throughout the body. PGLs are closely aligned with the distribution of the autonomic nervous system and preferentially arise in the
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Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
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Introduction Pheochromocytomas (PCCs) and paragangliomas (PGLs, together denoted as PPGLs) are rare endocrine tumors originating from chromaffin cells in the adrenal medulla (PCC) and extra-adrenal paraganglia (PGL). Sympathetic PPGLs secrete
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
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Introduction The Cancer Genome Atlas (TCGA) proposed that neuroendocrine tumors of adrenal paraganglia, pheochromocytomas (PCCs) and extra-adrenal paraganglia paragangliomas (PGLs, together denoted PPGL) can be divided into three main
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Hereditary Endocrine Cancer Group, Familial Cancer Clinic, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Confocal Microscopy Unit, Proteomics Unit, Endocrinology and Nutrition Service, Endocrinology and Nutrition Service, Department of Medical and Surgical Sciences, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029 Madrid, Spain
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Hereditary Endocrine Cancer Group, Familial Cancer Clinic, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Confocal Microscopy Unit, Proteomics Unit, Endocrinology and Nutrition Service, Endocrinology and Nutrition Service, Department of Medical and Surgical Sciences, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029 Madrid, Spain
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Hereditary Endocrine Cancer Group, Familial Cancer Clinic, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Confocal Microscopy Unit, Proteomics Unit, Endocrinology and Nutrition Service, Endocrinology and Nutrition Service, Department of Medical and Surgical Sciences, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029 Madrid, Spain
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Hereditary Endocrine Cancer Group, Familial Cancer Clinic, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Confocal Microscopy Unit, Proteomics Unit, Endocrinology and Nutrition Service, Endocrinology and Nutrition Service, Department of Medical and Surgical Sciences, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029 Madrid, Spain
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Hereditary Endocrine Cancer Group, Familial Cancer Clinic, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Confocal Microscopy Unit, Proteomics Unit, Endocrinology and Nutrition Service, Endocrinology and Nutrition Service, Department of Medical and Surgical Sciences, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029 Madrid, Spain
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Hereditary Endocrine Cancer Group, Familial Cancer Clinic, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Confocal Microscopy Unit, Proteomics Unit, Endocrinology and Nutrition Service, Endocrinology and Nutrition Service, Department of Medical and Surgical Sciences, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029 Madrid, Spain
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Introduction Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors of neural crest origin. Up to an estimated 60% of PCCs/PGLs are associated with germline or somatic mutations in one many susceptibility genes ( RET
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Introduction The last 15 years have brought significant advances in our understanding of the genetic basis of hereditary syndromes with a predisposition to pheochromocytoma (PC) and paraganglioma (PGL) (PCPGL) development. In the 1990s the genetic
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Introduction Phaeochromocytomas (PHEO) of the adrenal gland and sympathetic paragangliomas (PGL) are catecholamine-producing tumours. Although 10–30% of these tumours metastasise, histopathological criteria that discriminate malignant from benign