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J T W Kwon Department of Oncology, University of Oxford, Oxford, UK

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R J Bryant Department of Oncology, University of Oxford, Oxford, UK
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK

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E E Parkes Department of Oncology, University of Oxford, Oxford, UK

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Introduction Prostate cancer (PCa) is the second most commonly diagnosed cancer and the fifth most common cause of death in men worldwide ( Sung et al. 2021 ). Although the aetiology of PCa is multifactorial, genomics is a key variable

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Himisha Beltran Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

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Francesca Demichelis Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy

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Introduction The treatment landscape of advanced prostate cancer continues to evolve. Drugs with varied mechanisms of action now being used in earlier disease settings, and patients are living longer with longer exposure to systemic therapies

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Justine Vanhevel Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium

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Lieve Verlinden Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium

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Stefanie Doms Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium

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Hans Wildiers UZ Leuven, General Medical Oncology and Multidisciplinary Breast Center, Leuven, Belgium

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Annemieke Verstuyf Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium

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breast and prostate cancer: a Mendelian randomization study . International Journal of Epidemiology 48 1416 – 1424 . ( https://doi.org/10.1093/ije/dyy284 ) 30597039 Jiang X Ge T Chen CY 2021 The causal role of circulating vitamin D concentrations

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Ha Nguyen Division of Internal Medicine, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Komal Shah Division of Diagnostic Imaging, Department of Diagnostic Radiology, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Steven G Waguespack Division of Internal Medicine, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Mimi I Hu Division of Internal Medicine, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Mouhammed Amir Habra Division of Internal Medicine, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Maria E Cabanillas Division of Internal Medicine, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Naifa L Busaidy Division of Internal Medicine, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Roland Bassett Division of Science, Department of Biostatistics, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Shouhao Zhou Division of Science, Department of Biostatistics, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Priyanka C Iyer Division of Internal Medicine, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Garrett Simmons Division of Diagnostic Imaging, Department of Diagnostic Radiology, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Diana Kaya Division of Diagnostic Imaging, Department of Diagnostic Radiology, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Marie Pitteloud Division of Internal Medicine, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Sumit K Subudhi Division of Cancer Medicine, Department of Genitourinary Medical Oncology, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Adi Diab Division of Cancer Medicine, Department of Melanoma Medical Oncology, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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Ramona Dadu Division of Internal Medicine, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas Anderson Cancer Center, Houston, Texas, USA

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.2) 3 (5) 3 (14)  Hispanic 3 (3.6) 3 (5) 0 (0) Cancer type, n (%)  Melanoma 54 (65) 42 (68) 9 (43)  Prostate cancer 16 (19.3) 11 (18) 4 (19)  Renal cell carcinoma 8 (9.6) 5 (8) 3 (14

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James F H Pittaway Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Constantinos Lipsos Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Katia Mariniello Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Leonardo Guasti Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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with differential expression in small cell lung cancer cell lines. Structural analysis of the protein revealed it was highly homologous with the proteins Delta , Serrate and Notch from Drosophila melanogaster and it was termed ‘human Delta

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