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Christodoulos P Pipinikas, Alison M Berner, Teresa Sposito, and Christina Thirlwell

chromatin state of cancer cells ( Valastyan et al. 2012 ). It has been previously implicated in prostate cancer neuroendocrine differentiation ( Chang et al. 2018 ), while its overexpression results in alterations in H3K27me and increases the metastatic

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J Hadoux, D Malka, D Planchard, J Y Scoazec, C Caramella, J Guigay, V Boige, S Leboulleux, P Burtin, A Berdelou, Y Loriot, P Duvillard, C N Chougnet, D Déandréis, M Schlumberger, I Borget, M Ducreux, and E Baudin

high-grade neuroendocrine tumours? Cancer Chemotherapy and Pharmacology 59 637 – 642 . ( doi:10.1007/s00280-006-0306-6 ). Baudin E 2007 Gastroenteropancreatic endocrine tumors: clinical characterization before therapy . Nature Clinical

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Matthias Beyens, Timon Vandamme, Marc Peeters, Guy Van Camp, and Ken Op de Beeck

, Heldin & Westermark 1999 ). Angiogenesis signaling in neuroendocrine tumors The demand of high vascularization density for nutrient delivery to the growing tumor is one of the hallmarks of cancer ( Hanahan & Weinberg 2011 ). Pinato et al

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P H Kann, E Balakina, D Ivan, D K Bartsch, S Meyer, K-J Klose, Th Behr, and P Langer

et al. 1994 , Müller et al. 1994 , Dancygier 1995 , Nattermann et al. 1995 , Wiersema & Wiersema 1995 ). In addition, EUS enables to visualize small neuroendocrine tumours down to a diameter of 1–2 mm can be visualized ( Kann et al

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Jennifer A Chan, David P Ryan, Andrew X Zhu, Thomas A Abrams, Brian M Wolpin, Paige Malinowski, Eileen M Regan, Charles S Fuchs, and Matthew H Kulke

E Buzzoni R Mariani L Carnaghi C Somma L Zilembo N di Leo A 1996 Clinical efficacy of octreotide in the treatment of metastatic neuroendocrine tumors. A study by the Italian Trials in Medical Oncology Group . Cancer 77 402 – 408

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Florian Bösch, Katharina Brüwer, Annelore Altendorf-Hofmann, Christoph J Auernhammer, Christine Spitzweg, C Benedikt Westphalen, Stefan Boeck, Gabriele Schubert-Fritschle, Jens Werner, Volker Heinemann, Thomas Kirchner, Martin Angele, and Thomas Knösel

with metastatic GEP-NETs . Journal of Cancer 7 484 – 489 . ( https://doi.org/10.7150/jca.13711 ) 26958083 10.7150/jca.13711 Kloppel G Anlauf M 2005 Epidemiology, tumour biology and histopathological classification of neuroendocrine tumours of

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Maho Shibata and Michael M Shen

2010 Characterizing the contribution of stem/progenitor cells to tumorigenesis in the Pten −/− TP53 −/− prostate cancer model . Stem Cells 28 2129 – 2140 . ( doi:10.1002/stem.538 ). Abrahamsson PA di Sant'Agnese PA 1993 Neuroendocrine

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Vincenzo Marotta, Maria Chiara Zatelli, Concetta Sciammarella, Maria Rosaria Ambrosio, Marta Bondanelli, Annamaria Colao, and Antongiulio Faggiano

histological neuroendocrine differentiation has not been reported, such as primary hepatocellular cancer ( Spadaro et al . 2005 ) and breast cancer ( Giovanella et al . 2001 ). To date, the capability of circulating CgA in discriminating NEN from other

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Massimo Milione, Patrick Maisonneuve, Alessio Pellegrinelli, Federica Grillo, Luca Albarello, Paola Spaggiari, Alessandro Vanoli, Giovanna Tagliabue, Eleonora Pisa, Luca Messerini, Giovanni Centonze, Frediano Inzani, Aldo Scarpa, Mauro Papotti, Marco Volante, Fausto Sessa, Nicola Fazio, Giancarlo Pruneri, Guido Rindi, Enrico Solcia, Stefano La Rosa, and Carlo Capella

Introduction The coexistence of neuroendocrine and non-neuroendocrine components in the same neoplasm is a rare but well-known phenomenon in digestive system tumors. The 2010 World Health Organization (WHO) classification of tumors of the

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Michael Höpfner, Viola Baradari, Alexander Huether, Christof Schöfl, and Hans Scherübl

cancers is not well controlled by either biotherapy or chemotherapy. Thus, therapeutic options to inhibit the growth and spread of neuroendocrine gastrointestinal tumours (NET) are still unsatisfactory. In the light of the particular biology of NET