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Introduction Pheochromocytomas (PCs) are catecholamine-secreting tumours of chromaffin cells of the adrenal medulla and are closely related to paragangliomas (PGLs) which arise from sympathetic and parasympathetic chains ( Favier et al . 2005

Introduction Paraganglioma–pheochromocytoma Paragangliomas and pheochromocytomas are neuroendocrine tumors that arise mainly in the adrenal medulla or paraganglia of the head and neck, but may also develop in abdominal or thoracic

Introduction Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors arising from the adrenal medulla or extra-adrenal paraganglia, respectively. Paragangliomas can be found in the sympathetic nervous system of the thorax

Introduction Pheochromocytomas and paragangliomas are sympathetic neural-derived neoplasms. Over one third of these tumors carry germline mutations in one of the ten distinct genes ( Jafri & Maher 2012 ). Remarkably, somatic events in

clinical features, i.e., renal carcinoma alone, renal carcinoma associated with pheochromocytoma, and pheochromocytoma alone ( Crossey et al. 1995 , Zbar et al. 1996 ). Pheochromocytomas and paragangliomas (PPGLs) are neural

these metabolic pathways or restoring altered pathways can lead to new approaches in cancer treatment. Pheochromocytoma and paraganglioma Pheochromocytomas (PHEOs)/paragangliomas (PGLs) are rare neuroendocrine tumors that produce catecholamines ( Lenders

Learning points Know the molecular taxonomy of pheochromocytoma and/or paraganglioma (PPGL) and the relationship between various genotypes and imaging phenotypes; Describe imaging features of SDHx -related PPGL; Understand

pheochromocytoma, termed ‘paraganglioma’, was also not linked to any germline mutations and paragangliomas located in the head and neck region (HN-paragangliomas) were considered as separate entities from those located in the abdomen, chest, and pelvis. In 2000

, Bausch et al . 2006 ), were known to be associated with pheochromocytomas, all with well-defined syndromic manifestations, and the genetic associations of extra-adrenal paragangliomas had not been determined. The main role of pathology was to make a

Introduction Pheochromocytomas and paragangliomas are neuroendocrine tumors that make up less than 1% of all endocrine neoplasias. Pheochromocytomas and paragangliomas arise from the adrenal medulla and the extra-adrenal paraganglia