Search Results

You are looking at 11 - 20 of 171 items for :

  • malignant paraganglioma x
  • All content x
Clear All
Free access

Tomáš Zelinka, Henri J L M Timmers, Anna Kozupa, Clara C Chen, Jorge A Carrasquillo, James C Reynolds, Alexander Ling, Graeme Eisenhofer, Ivica Lazúrová, Karen T Adams, Millie A Whatley, Jiří Widimský Jr, and Karel Pacak

Human Development at the NIH and by the ethics committee of the First Faculty of Medicine. All patients provided written informed consent. Table 2 Characteristics of subjects with malignant pheochromocytoma and paraganglioma with succinate dehydrogenase

Free access

A Perren, S Schmid, T Locher, P Saremaslani, C Bonvin, P U Heitz, and P Komminoth

Introduction Activating mutations of the serine/threonine kinase gene BRAF located on chromosome 7q34 have recently been reported in a wide range of malignancies, with the highest frequency (66%) occurring in malignant melanomas

Free access

Noriko Kimura, Ryoichi Takayanagi, Nae Takizawa, Eiji Itagaki, Takayuki Katabami, Narihiko Kakoi, Hiromi Rakugi, Yukihiro Ikeda, Akiyo Tanabe, Takeshi Nigawara, Sadayoshi Ito, Itaru Kimura, Mitsuhide Naruse, and The Phaeochromocytoma Study Group in Japan

Introduction Phaeochromocytomas (PHEO) of the adrenal gland and sympathetic paragangliomas (PGL) are catecholamine-producing tumours. Although 10–30% of these tumours metastasise, histopathological criteria that discriminate malignant from benign

Open access

Tiantian Liu, Taylor C Brown, C Christofer Juhlin, Adam Andreasson, Na Wang, Martin Bäckdahl, James M Healy, Manju L Prasad, Reju Korah, Tobias Carling, Dawei Xu, and Catharina Larsson

/76 1/19 (5%) 1/95 (1%) Paraganglioma (PGL) 1/13 (8%) – 1/13 (8%)  Malignant PGL a 1/9 (11%) – 1/9 (11%)  Benign PGL 0/4 – 0/4 a According to the AFIP criteria ( Lack 2007 ). TERT mRNA expression in tumors with C228T Given that

Free access

Lucia Martiniova, Shiromi M Perera, Frederieke M Brouwers, Salvatore Alesci, Mones Abu-Asab, Amanda F Marvelle, Dale O Kiesewetter, David Thomasson, John C Morris, Richard Kvetnansky, Arthur S Tischler, James C Reynolds, Antonio Tito Fojo, and Karel Pacak

hypertensive complications, including stroke, myocardial infarction, and tachyarrhythmia. Current treatments for malignant pheochromocytoma or paraganglioma include targeted radiation using [ 131 I]meta-iodobenzylguanidine ([ 131 I]MIBG), cytotoxic chemotherapy

Free access

V H M Tsang, T Dwight, D E Benn, G Y Meyer-Rochow, A J Gill, M Sywak, S Sidhu, D Veivers, C M Sue, B G Robinson, R J Clifton-Bligh, and N R Parker

characteristics: pheochromocytomas and paragangliomas ID Age a Sex Tumour Pathology b Germline mutation c Follow Up (years) Size (mm) SDHA IHC SDHB IHC VHL Somatic mutation P1 27 F EA PGL Malignant VHL (c.470C>T (p.Thr157Ile) NA 13 P2 41 F PC Malignant SDHB (c

Open access

Diana E Benn, Bruce G Robinson, and Roderick J Clifton-Bligh

:10.1038/ng1095-144 ). Brouwers FM Eisenhofer G Tao JJ Kant JA Adams KT Linehan WM Pacak K 2006 High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic

Free access

Umasuthan Srirangalingam, Bernard Khoo, Lisa Walker, Fiona MacDonald, Robert H Skelly, Emad George, David Spooner, Linda B Johnston, John P Monson, Ashley B Grossman, W M Drake, Scott A Akker, Patrick J Pollard, Nick Plowman, Norbert Avril, Daniel M Berney, Jacky M Burrin, Rodney H Reznek, V K Ajith Kumar, Eamonn R Maher, and Shern L Chew

mutation carriers, malignant paragangliomas were evident in 31% of subjects, while no subjects have developed malignant disease in the VHL cohort to date. These data correlate with the larger tumour size noted in the SDHB mutation cohort compared with

Free access

Jenny Welander, Peter Söderkvist, and Oliver Gimm

Grossman AB 2007 The diagnosis and management of malignant phaeochromocytoma and paraganglioma . Endocrine-Related Cancer 14 569 – 585 . doi:10.1677/ERC-07-0074 . Comino-Mendez I Gracia-Aznarez FJ Schiavi F Landa I Leandro-Garcia LJ

Free access

Annika Blank, Anja M Schmitt, Esther Korpershoek, Francien van Nederveen, Thomas Rudolph, Nicole Weber, Räto Thomas Strebel, Ronald de Krijger, Paul Komminoth, and Aurel Perren

-adrenal pheochromocytomas and relationship to prognosis: a clinicopathological analysis of 116 adrenal pheochromocytomas and 30 extra-adrenal sympathetic paragangliomas including 38 malignant tumors . Endocrine Pathology 16 23 – 32 doi:10.1385/EP:16:1:023 . Komminoth