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Guido Rindi and Frediano Inzani

unattributable to any given organ if not tested for site-specific antigens (i.e. hormones or transcription factors) ( Fig. 1 ). Figure 1 The neuroendocrine neoplasm category. The neuroendocrine cancer is defined as neuroendocrine neoplasm (NEN), a category

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Yeting Du, Monica Ter-Minassian, Lauren Brais, Nichole Brooks, Amanda Waldron, Jennifer A Chan, Xihong Lin, Peter Kraft, David C Christiani, and Matthew H Kulke

Patients with a confirmed diagnosis of NET (excluding small cell lung cancer) were recruited to an Institutional Review Board-approved study in the gastrointestinal clinic at Dana-Farber Cancer Institute (DFCI). A total of 1396 patients with neuroendocrine

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Atsuko Kasajima, Yuichi Ishikawa, Ayaka Iwata, Katja Steiger, Naomi Oka, Hirotaka Ishida, Akira Sakurada, Hiroyoshi Suzuki, Toru Kameya, Björn Konukiewitz, Günter Klöppel, Yoshinori Okada, Hironobu Sasano, and Wilko Weichert

-generation sequencing of pulmonary large cell neuroendocrine carcinoma reveals small cell carcinoma-like and non-small cell carcinoma-like subsets . Clinical Cancer Research 22 3618 – 3629 . ( ) 10.1158/1078-0432.CCR-15

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Rajeev Mishra, Subhash Haldar, Surabhi Suchanti, and Neil A Bhowmick

the cancer cell morphogenesis, implicated in the acquisition of the neuron-like cell shape observed in neuroendocrine prostate cancer. (Lopes et al. 2016, Takayama et al. 2018)  NAV1 Neuron navigator 1 Expressed in brain astrocytoma

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Kimberly Kamp, Ronald A M Damhuis, Richard A Feelders, and Wouter W de Herder

populations and National Cancer Registries is also a major drawback in the reported series. Etiologic explanations ranged from incidental discovery to stimulation of cancer growth by neuroendocrine factors. The aim of this study was to determine whether there

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Annemiek Walenkamp, Guillermo Crespo, Felipe Fierro Maya, Reidar Fossmark, Peter Igaz, Anja Rinke, Gianluca Tamagno, Giovanni Vitale, Kjell Öberg, and Tim Meyer

Introduction Neuroendocrine tumours (NETs) are diverse in their site of origin and clinical behaviour, ranging from highly aggressive small cell cancers of the lung to indolent, low-grade tumours of the small bowel ( Yao et al . 2008 a ). Symptoms

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Tim J Takkenkamp, Mathilde Jalving, Frederik J H Hoogwater, and Annemiek M E Walenkamp

Introduction NETs are tumours that arise from epithelial cells with both neurological and endocrinological functions and are most commonly located in the gastro-intestinal (GI) tract (

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Lucas Leite Cunha, Marjory Alana Marcello, Vinicius Rocha-Santos, and Laura Sterian Ward

, target and destroy cancer cells. By doing so, immune checkpoint inhibitors also activate immune memory, leading to a sustained antitumor response. Additionally, since these drugs primarily act on the host, it may be possible to use them against many tumor

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Mei Dong and James C Yao

that genetic cancer syndromes in the mTOR pathway are linked in the development of neuroendocrine tumors. In a phase II study conducted at the University of Texas M. D. Anderson Cancer Center, including 30 patients (four patients with BC) with

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Aristides Lytras and George Tolis

cancer in MEN4 ? Adrenocortical rest tumors Interstitial cell tumors Testicular microlithiasis Other male organ involvement Prostate neuroendocrine tumors and carcinoids ( MEN2B ) Cysts and ‘hyper-nephroid’ tumors of epididymis Aggressive prostate cancer