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María Gutiérrez-Salmerón, Silvia Rocío Lucena, Ana Chocarro-Calvo, José Manuel García-Martínez, Rosa M Martín Orozco, and Custodia García-Jiménez

the use of in vivo models which are often difficult to interpret. In vivo models allow the study of interactions between different tissues and organs. Non-mammalian experimental organisms with a short life cycle (Zebrafish, C. elegans and

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Douglas J Kojetin, Thomas P Burris, Elwood V Jensen, and Sohaib A Khan

zebrafish thyroid hormone receptor alpha . General and Comparative Endocrinology 155 176 – 189 . Tanenbaum DM Wang Y Williams SP Sigler PB 1998 Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains

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Luke A Selth, Wayne D Tilley, and Lisa M Butler

microRNA spectrum in 12 body fluids . Clinical Chemistry 56 1733 – 1741 . doi:10.1373/clinchem.2010.147405 . Wienholds E Koudijs MJ van Eeden FJ Cuppen E Plasterk RH 2003 The microRNA-producing enzyme Dicer1 is essential for zebrafish

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Kevin C Knower, Sarah Q To, Yuet-Kin Leung, Shuk-Mei Ho, and Colin D Clyne

). Fang X Thornton C Scheffler BE Willett KL 2013 Benzo[a]pyrene decreases global and gene specific DNA methylation during Zebrafish development . Environmental Toxicology and Pharmacology 36 40 – 50 . ( doi:10.1016/j.etap.2013

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Claire E Fletcher, D Alwyn Dart, and Charlotte L Bevan

signalling in humans, being performed in zebrafish, rat breast tissue and mouse spleen ( Kovalchuk et al . 2007 , Cohen et al . 2008 , Dai et al . 2008 ), and to date only around 15 studies have examined estrogen regulation of miRs in human cells ( Iorio

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M A Marcello, P Malandrino, J F M Almeida, M B Martins, L L Cunha, N E Bufalo, G Pellegriti, and L S Ward

BPA disrupts thyroid through mechanisms that are not yet well known. It seems to be a selective antagonist of the thyroid hormone receptor β isoform ( Zoeller et al . 2005 ), and recently it has been documented that in an in vivo model (zebrafish

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Miguel A Zaballos, Adrián Acuña-Ruiz, Marta Morante, Piero Crespo, and Pilar Santisteban

. 2013 ). IL17RD/SEF Interleukin 17 receptor D (IL17RD), also known as similar expression to FGF (SEF), was first identified as an antagonist of fibroblast growth factor (FGF) signaling during zebrafish development ( Tsang et al. 2002 ). SEF