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Giovanni Vitale, Germano Gaudenzi, Alessandra Dicitore, Franco Cotelli, Diego Ferone, and Luca Persani

a model in cancer research, focusing on potential applications in neuroendocrine tumors (NETs). Zebrafish as a cancer model Although fish do not have certain organs found in mammals (breast, prostate, and lung), zebrafish spontaneously develops

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M Fraenkel, M Kim, A Faggiano, W W de Herder, G D Valk, and On behalf of the Knowledge NETwork

in neuroendocrine tumors: a population based study from a cancer registry . Pathology Oncology Research 17 759 – 763 . ( doi:10.1007/s12253-011-9382-y ). Chow JS Chen CC Ahsan H Neugut AI 1996 A population-based study of the incidence

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Volker Fendrich, Jens Waldmann, Farzad Esni, Annette Ramaswamy, Michael Mullendore, Malte Buchholz, Anirban Maitra, and Georg Feldmann

eliminates medulloblastoma in Ptc1(+/−)p53(−/ −) mice. Cancer Cell 6 229 –240. Rorstad O 2005 Prognostic indicators for carcinoid neuroendocrine tumors of the gastrointestinal tract. Journal of Surgical Oncology 89 151

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Didier Marot, Ivan Bieche, Chantal Aumas, Stéphanie Esselin, Céline Bouquet, Sophie Vacher, Gwendal Lazennec, Michel Perricaudet, Frederique Kuttenn, Rosette Lidereau, and Nicolas de Roux

Introduction KiSS1 was first described as a gene encoding a protein involved in metastasis inhibition of melanoma and breast cancer ( Lee et al. 1996 , Lee & Welch 1997 a , b ). Loss of KiSS1 expression has also been correlated

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Kathrin Zitzmann, Enrico de Toni, Janina von Rüden, Stephan Brand, Burkhard Göke, Rüdiger P Laubender, and Christoph J Auernhammer

H 2006 The insulin-like growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours . Endocrine-Related Cancer 13 135 – 149 doi:10.1677/erc.1.01090 . Horak P Pils D Haller G

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Hermine Mohr and Natalia S Pellegata

SN Zajac-Kaye M 2015 Targeting focal adhesion kinase and resistance to mtor inhibition in pancreatic neuroendocrine tumors. Journal of National Cancer Institute 107 djv123. ( doi:10.1093/jnci/djv123 ) Fritz A Walch A Piotrowska

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Nora Sahnane, Daniela Furlan, Matilde Monti, Chiara Romualdi, Alessandro Vanoli, Emanuela Vicari, Enrico Solcia, Carlo Capella, Fausto Sessa, and Stefano La Rosa

Introduction High-grade (or poorly differentiated) gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) are aggressive cancers with a high propensity for distant metastases. Like the more frequent pulmonary counterparts, they have

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Yulong Li and William F Simonds

cases. Nonfunctioning pancreatic neuroendocrine tumors in MEN1 MEN1 is a rare autosomal-dominant familial cancer syndrome caused by germline loss-of-function mutation of the MEN1 tumor-suppressor gene ( Marx et al. 1999 ). The syndrome is

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O Hentic, P Hammel, A Couvelard, V Rebours, M Zappa, M Palazzo, F Maire, G Goujon, A Gillet, P Lévy, and P Ruszniewski

neuroendocrine tumors . Cancer 92 1101 – 1107 . ( doi:10.1002/1097-0142(20010901)92:5<1101::AID-CNCR1426>3.0.CO;2-V ). Hainsworth JD Spigel DR Litchy S Greco FA 2006 Phase II trial of paclitaxel, carboplatin, and etoposide in advanced poorly

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Gina Chia-Yi Chu, Haiyen E Zhau, Ruoxiang Wang, André Rogatko, Xu Feng, Majd Zayzafoon, Youhua Liu, Mary C Farach-Carson, Sungyong You, Jayoung Kim, Michael R Freeman, and Leland W K Chung

previous reports showing that cancer cells undergoing EMT expressed stem cell characteristics ( Kong et al . 2011 ). The emergence of an neuroendocrine phenotype in the LNCaP as well as ARCaP M cell backgrounds in response to RANKL–RANK signaling has not