a model in cancer research, focusing on potential applications in neuroendocrine tumors (NETs). Zebrafish as a cancer model Although fish do not have certain organs found in mammals (breast, prostate, and lung), zebrafish spontaneously develops
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Giovanni Vitale, Germano Gaudenzi, Alessandra Dicitore, Franco Cotelli, Diego Ferone, and Luca Persani
M Fraenkel, M Kim, A Faggiano, W W de Herder, G D Valk, and On behalf of the Knowledge NETwork
in neuroendocrine tumors: a population based study from a cancer registry . Pathology Oncology Research 17 759 – 763 . ( doi:10.1007/s12253-011-9382-y ). Chow JS Chen CC Ahsan H Neugut AI 1996 A population-based study of the incidence
Volker Fendrich, Jens Waldmann, Farzad Esni, Annette Ramaswamy, Michael Mullendore, Malte Buchholz, Anirban Maitra, and Georg Feldmann
eliminates medulloblastoma in Ptc1(+/−)p53(−/ −) mice. Cancer Cell 6 229 –240. Rorstad O 2005 Prognostic indicators for carcinoid neuroendocrine tumors of the gastrointestinal tract. Journal of Surgical Oncology 89 151
Didier Marot, Ivan Bieche, Chantal Aumas, Stéphanie Esselin, Céline Bouquet, Sophie Vacher, Gwendal Lazennec, Michel Perricaudet, Frederique Kuttenn, Rosette Lidereau, and Nicolas de Roux
Introduction KiSS1 was first described as a gene encoding a protein involved in metastasis inhibition of melanoma and breast cancer ( Lee et al. 1996 , Lee & Welch 1997 a , b ). Loss of KiSS1 expression has also been correlated
Kathrin Zitzmann, Enrico de Toni, Janina von Rüden, Stephan Brand, Burkhard Göke, Rüdiger P Laubender, and Christoph J Auernhammer
H 2006 The insulin-like growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours . Endocrine-Related Cancer 13 135 – 149 doi:10.1677/erc.1.01090 . Horak P Pils D Haller G
Hermine Mohr and Natalia S Pellegata
SN Zajac-Kaye M 2015 Targeting focal adhesion kinase and resistance to mtor inhibition in pancreatic neuroendocrine tumors. Journal of National Cancer Institute 107 djv123. ( doi:10.1093/jnci/djv123 ) Fritz A Walch A Piotrowska
Nora Sahnane, Daniela Furlan, Matilde Monti, Chiara Romualdi, Alessandro Vanoli, Emanuela Vicari, Enrico Solcia, Carlo Capella, Fausto Sessa, and Stefano La Rosa
Introduction High-grade (or poorly differentiated) gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) are aggressive cancers with a high propensity for distant metastases. Like the more frequent pulmonary counterparts, they have
Yulong Li and William F Simonds
cases. Nonfunctioning pancreatic neuroendocrine tumors in MEN1 MEN1 is a rare autosomal-dominant familial cancer syndrome caused by germline loss-of-function mutation of the MEN1 tumor-suppressor gene ( Marx et al. 1999 ). The syndrome is
O Hentic, P Hammel, A Couvelard, V Rebours, M Zappa, M Palazzo, F Maire, G Goujon, A Gillet, P Lévy, and P Ruszniewski
neuroendocrine tumors . Cancer 92 1101 – 1107 . ( doi:10.1002/1097-0142(20010901)92:5<1101::AID-CNCR1426>3.0.CO;2-V ). Hainsworth JD Spigel DR Litchy S Greco FA 2006 Phase II trial of paclitaxel, carboplatin, and etoposide in advanced poorly
Gina Chia-Yi Chu, Haiyen E Zhau, Ruoxiang Wang, André Rogatko, Xu Feng, Majd Zayzafoon, Youhua Liu, Mary C Farach-Carson, Sungyong You, Jayoung Kim, Michael R Freeman, and Leland W K Chung
previous reports showing that cancer cells undergoing EMT expressed stem cell characteristics ( Kong et al . 2011 ). The emergence of an neuroendocrine phenotype in the LNCaP as well as ARCaP M cell backgrounds in response to RANKL–RANK signaling has not
