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Christina Schug, Sarah Urnauer, Carsten Jaeckel, Kathrin A Schmohl, Mariella Tutter, Katja Steiger, Nathalie Schwenk, Markus Schwaiger, Ernst Wagner, Peter J Nelson, and Christine Spitzweg

synthetic hypoxia-inducible factor (HIF)1-responsive promoter that selectively activates NIS transgene expression in tumors by targeting hypoxia, a central feature of solid tumors ( Knoop et al. 2013 , 2015 , Muller et al. 2016 ). The use of gene

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S M Hyder

angiogenesis such as thrombospondin-1 (TSP-1), soluble (s)VEGF receptors and tissue inhibitor of metalloproteinases, etc. Several factors such as hypoxia or loss of tumor suppressors and angiogenesis inhibitors can disrupt the angiogenic balance in a tissue

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Frederieke M Brouwers, Sven Gläsker, Amanda F Nave, Alexander O Vortmeyer, Irina Lubensky, Steven Huang, Mones S Abu-Asab, Graeme Eisenhofer, Robert J Weil, Deric M Park, W Marston Linehan, Karel Pacak, and Zhengping Zhuang

, a plasma membrane-bound tyrosine kinase, which is expressed by neuroendocrine and neural cells. The molecular basis of VHL disease is different. Biallelic inactivation of the VHL tumor suppressor gene leads to stabilization of hypoxia inducible

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Douglas Wiseman, James D McDonald, Dhaval Patel, Electron Kebebew, Karel Pacak, and Naris Nilubol

associated with volume overload, such as patient’s change in weight (maximum postoperative weight minus preoperative weight, in kgams), the use of diuretics postoperatively; hypoxia in the absence of other obvious causes and delayed return of bowel function

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E Tiligada

structure, function, stability, growth and survival. The environmental and microenvironmental stimuli that act as potential stressors are numerous. Typically, they include hyper- or hypothermia, hypoxia, reactive oxygen species (ROS), radiation, starvation

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Libero Santarpia, Milena Nicoloso, and George A Calin

and 125b favors the constitutive activation of the ERBB prosurvival pathway ( Scott et al . 2007 ). Another study showed that one relevant target of miR-210 in hypoxia was the surface receptor Ephrin-A3 ( Fasanaro et al . 2008 ). miR-210

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Dara Hope Cohen and Derek LeRoith

( Trayhurn & Wood 2004 ). Leptin expression is induced by hypoxia via the hypoxia-induced factor 1, and hypoxia frequently occurs in solid tumors ( Ambrosini et al . 2002 , Grosfeld et al . 2002 ). Furthermore, leptin can promote neoangiogenesis through

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Valdemar Máximo, Jorge Lima, Hugo Prazeres, Paula Soares, and Manuel Sobrinho-Simões

to that observed in ischemic hearts after reperfusion ( Borutaite & Brown 2003 ). Hürthle cell tumors and hypoxia-inducible factor 1 stabilization and angiogenesis There is evidence suggesting that mitochondrial dysfunction may lead to the

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David J Gross, Gabriel Munter, Menachem Bitan, Tali Siegal, Alberto Gabizon, Ronny Weitzen, Ofer Merimsky, Aliza Ackerstein, Asher Salmon, Avishai Sella, and Shimon Slavin

( Adams et al. 2002 ). However, it has recently been shown that tumor oxygen deprivation can be a double-edged sword, since hypoxia induced signaling via the c -Met in tumor cells can result in a more aggressive tumor phenotype ( Bottaro & Liotta 2003

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Paraskevi Xekouki and Constantine A Stratakis

reactive oxygen species (ROS). In normoxic conditions, a family of oxygen-dependent enzymes known as prolyl hydroxylases (PHD) 1, 2, and 3 (also known as Egln2 , Egln1 , and Egln3 ) hydroxylate the three α subunits of hypoxia inducible factor α (HIF1α