Introduction Pheochromocytomas (PC) and paragangliomas (PGLs) are neuroendocrine tumors derived from neural crest cells of the sympathetic and parasympathetic nervous system – PCs arising in the adrenal medulla and PGLs in paraganglia outside
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Trisha Dwight, Aidan Flynn, Kaushalya Amarasinghe, Diana E Benn, Richard Lupat, Jason Li, Daniel L Cameron, Annette Hogg, Shiva Balachander, Ida L M Candiloro, Stephen Q Wong, Bruce G Robinson, Anthony T Papenfuss, Anthony J Gill, Alexander Dobrovic, Rodney J Hicks, Roderick J Clifton-Bligh, and Richard W Tothill
Martin Gotthardt, Martin P Béhé, Julia Grass, Artur Bauhofer, Anja Rinke, Meike L Schipper, Marc Kalinowski, Rudolf Arnold, Wim J G Oyen, and Thomas M Behr
scintigraphy and functional status/localisation of the tumours was determined in the same manner (paragangliomas were excluded from this evaluation). Results Patients From July 2001 to July 2003, 122 GRS and SRS
Francien H van Nederveen, Esther Korpershoek, Ronald J deLeeuw, Albert A Verhofstad, Jacques W Lenders, Winand N M Dinjens, Wan L Lam, and Ronald R de Krijger
Introduction Pheochromocytomas (PCC) are rare neuro-endocrine tumors arising from the adrenal medulla. Similar tumors arise from extra-adrenal chromaffin tissues, and are now referred to as sympathetic paragangliomas (PGLs; Baguet et al . 2004
Nele Garbrecht, Martin Anlauf, Anja Schmitt, Tobias Henopp, Bence Sipos, Andreas Raffel, Claus F Eisenberger, Wolfram T Knoefel, Marianne Pavel, Christian Fottner, Thomas J Musholt, Anja Rinke, Rudolf Arnold, Uta Berndt, Ursula Plöckinger, Bertram Wiedenmann, Holger Moch, Philipp U Heitz, Paul Komminoth, Aurel Perren, and Günter Klöppel
) syndromes. Somatostatin expression was also found in gangliocytic paragangliomas (GCPGs; Hamid et al . 1986 , Tischler et al . 2004 ). All of these tumors are uncommon. Our knowledge of their incidence, histopathology, biology, hereditary background, and
A Perren, S Schmid, T Locher, P Saremaslani, C Bonvin, P U Heitz, and P Komminoth
tumors including pheochromocytomas (PCCs), paragangliomas (PGLs) and medullary thyorid carcinomas (MTCs) evolve from neural-crest-derived cells ( Pasini et al. 1996 ). Secondly, on a molecular genetic level, activation of tyrosine kinases ( Ret
Tiantian Liu, Taylor C Brown, C Christofer Juhlin, Adam Andreasson, Na Wang, Martin Bäckdahl, James M Healy, Manju L Prasad, Reju Korah, Tobias Carling, Dawei Xu, and Catharina Larsson
pheochromocytoma (PCC) and an adrenocortical carcinoma (ACC). Pheochromocytomas (PCC) and abdominal paragangliomas (PGL) are typically catecholamine-producing tumors, originating from chromaffin cells in the paraganglia inside or outside the adrenal medulla ( Elder
Elena Rapizzi, Rossella Fucci, Elisa Giannoni, Letizia Canu, Susan Richter, Paolo Cirri, and Massimo Mannelli
paragangliomas (PGL), which harbor mutations in the tricarboxylic acid cycle enzymes, such as fumarate hydratase (FH) ( Castro-Vega et al . 2014 ) and succinate dehydrogenase (SDH) ( Baysal et al . 2000 , and for recent reviews, see Dahia (2014) and Martucci
Graeme Eisenhofer, Karel Pacak, Thanh-Truc Huynh, Nan Qin, Gennady Bratslavsky, W Marston Linehan, Massimo Mannelli, Peter Friberg, Stefan K Grebe, Henri J Timmers, Stefan R Bornstein, and Jacques W M Lenders
Introduction Phaeochromocytomas and paragangliomas (PPGLs) are heterogeneous tumours with highly variable signs and symptoms and diverse clinical presentations ( Manger 2009 ). Much of the heterogeneity is due to wide-ranging variations in the types
Thomas G Papathomas, Lindsey Oudijk, Ellen C Zwarthoff, Edward Post, Floor A Duijkers, Max M van Noesel, Leo J Hofland, Patrick J Pollard, Eamonn R Maher, David F Restuccia, Richard A Feelders, Gaston J H Franssen, Henri J Timmers, Stefan Sleijfer, Wouter W de Herder, Ronald R de Krijger, Winand N M Dinjens, and Esther Korpershoek
pheochromocytomas (PCCs) and paragangliomas (PGLs) ( Vinagre et al . 2013 , Liu et al . 2014 ). In the current study, we examined the presence of these mutations in tumor types originating from the adrenal gland and extra-adrenal paraganglia including ACCs, PCCs
Vanessa D'Antongiovanni, Serena Martinelli, Susan Richter, Letizia Canu, Daniele Guasti, Tommaso Mello, Paolo Romagnoli, Karel Pacak, Graeme Eisenhofer, Massimo Mannelli, and Elena Rapizzi
Introduction Germline mutations in nuclear genes encoding succinate dehydrogenase (SDH), or mitochondrial complex II, are related with the occurrence of pheochromocytoma/paraganglioma (Pheo/PGL). SDH is a tetrameric protein composed by two
