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Albert Beckers Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Daniel Fernandes School of Archaeology and Earth Institute, University College Dublin, Belfield, Dublin, Ireland
Department of Life Sciences, Centro de Investigação em Antropologia e Saúde, University of Coimbra, Coimbra, Portugal

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Frederic Fina Assistance Publique Hôpitaux de Marseille (AP-HM) Hôpital Nord, Service de Transfert d’Oncologie Biologique, and Laboratoire de Biologie Médicale, and Aix-Marseille Université, Inserm, CRO2 UMR_S 911, Marseille, France

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Mario Novak School of Archaeology and Earth Institute, University College Dublin, Belfield, Dublin, Ireland

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Angelo Abati Department of Legal Medicine, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Liliya Rostomyan Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Albert Thiry Department of Pathology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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L’Housine Ouafik Assistance Publique Hôpitaux de Marseille (AP-HM) Hôpital Nord, Service de Transfert d’Oncologie Biologique, and Laboratoire de Biologie Médicale, and Aix-Marseille Université, Inserm, CRO2 UMR_S 911, Marseille, France

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Bertrand Pasture Office of the Conservator, Muséum régionale des Sciences naturelles, Mons, Belgium

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Ron Pinhasi School of Archaeology and Earth Institute, University College Dublin, Belfield, Dublin, Ireland

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Adrian F Daly Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Article Type:
Letter
DOI:
https://doi.org/10.1530/ERC-16-0558
Volume/Issue:
Volume 24: Issue 2
Free access
Vinciane Corman Department of Endocrinology, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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Iulia Potorac Department of Endocrinology, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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Florence Manto Faculty of Medicine, Université de Liège, Liège, Belgium

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Sarah Dassy Department of Oncology, St Nikolaus-Hospital, Eupen, Belgium

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Karin Segers Department of Human Genetics, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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Albert Thiry Department of Anatomo-pathology, Centre Hospitalier Universitaire de Liège, Université de Liège, Liège, Belgium

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Vincent Bours Department of Human Genetics, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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Adrian F Daly Department of Endocrinology, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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Albert Beckers Department of Endocrinology, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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Breast cancer is rare in male patients. Certain predisposing factors, be they genetic (e.g., BRCA2 gene mutations) or hormonal (imbalance between estrogen and androgen levels), have been implicated in male breast cancer pathophysiology. Male-to-female (MtF) transsexualism is a condition that generally involves cross-sex hormone therapy. Anti-androgens and estrogens are used to mimic the female hormonal environment and induce the cross-sex secondary characteristics. In certain situations, the change in the hormonal milieu can be disadvantageous and favor the development of hormone-dependent pathologies, such as cancer. We report a case of a MtF transgender patient who developed breast cancer after 7 years of cross-sex hormonal therapy. The patient was found to be BRCA2 positive, and suffered recurrent disease. The patient was unaware of being a member of an established BRCA2 mutation-positive kindred. This represents the first case of a BRCA2 mutation predisposing to breast cancer in a MtF transgender patient.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0057
Volume/Issue:
Volume 23: Issue 5
Free access