Search Results
You are looking at 1 - 1 of 1 items for
- Author: A-M C Dingemans x
- Refine by access: All content x
Search for other papers by Laura Moonen in
Google Scholar
PubMed
Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands
Search for other papers by Jules L Derks in
Google Scholar
PubMed
Search for other papers by Lisa M Hillen in
Google Scholar
PubMed
Search for other papers by Robert Jan van Suylen in
Google Scholar
PubMed
Search for other papers by Michael A den Bakker in
Google Scholar
PubMed
Search for other papers by Jan H von der Thüsen in
Google Scholar
PubMed
Search for other papers by Ronald A Damhuis in
Google Scholar
PubMed
Search for other papers by Wieneke A Buikhuisen in
Google Scholar
PubMed
Search for other papers by Esther C van den Broek in
Google Scholar
PubMed
Search for other papers by Jos Maessen in
Google Scholar
PubMed
Search for other papers by Alexander P W M Maat in
Google Scholar
PubMed
Search for other papers by Paul van Schil in
Google Scholar
PubMed
Department of Pathology, Maasstad Hospital, Rotterdam, The Netherlands
Search for other papers by Ernst J M Speel in
Google Scholar
PubMed
Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands
Search for other papers by A-M C Dingemans in
Google Scholar
PubMed
The predictive value of the extent of peri-operative lymph node (LN) sampling in relation to disease relapse in patients with pulmonary carcinoid (PC) is unknown. Furthermore, post-surgery follow-up recommendations rely on institutional retrospective studies with short follow-ups. We aimed to address these shortcomings by examining the relation between LN sampling and relapse in a population-based cohort with long-term follow-up. By combining the Dutch nationwide pathology and cancer registries, all patients with surgically resected PC (2003–2012) were included in this analysis (last update 2020). The extent of surgical LN dissection was scored for the number of LN samples, location (hilar/mediastinal), and completeness of resection according to European Society of Thoracic Surgeons (ESTS) guidelines. Relapse-free interval (RFI) was evaluated using Kaplan Meier and multivariate regression analysis. 662 patients were included. The median follow-up was 87.5 months. Relapse occurred in 10% of patients, mostly liver (51.8%) and locoregional sites (45%). The median RFI was 48.1 months (95% CI 36.8–59.4). Poor prognostic factors were atypical carcinoid, pN1/2, and R1/R2 resection. In 546 patients LN dissection data could be retrieved; at least one N2 LN was examined in 44% and completeness according to ESTS in merely 7%. In 477 cN0 patients, 5.9% had pN1 and 2.5% had pN2 disease. In conclusion, relapse occurred in 10% of PC patients with a median RFI of 48.1 months thereby underscoring the necessity of long-term follow-up. Extended mediastinal LN sampling was rarely performed but systematic nodal evaluation is recommended as it provides prognostic information on distant relapse.
