Search Results

You are looking at 1 - 2 of 2 items for

  • Author: Adele Vivacqua x
  • Refine by access: All content x
Clear All Modify Search
Paola De Marco Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy

Search for other papers by Paola De Marco in
Google Scholar
PubMed
Close
,
Enrica Romeo Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy

Search for other papers by Enrica Romeo in
Google Scholar
PubMed
Close
,
Adele Vivacqua Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy

Search for other papers by Adele Vivacqua in
Google Scholar
PubMed
Close
,
Roberta Malaguarnera Endocrinology, Department of Health, University Magna Graecia of Catanzaro, Catanzaro, Italy

Search for other papers by Roberta Malaguarnera in
Google Scholar
PubMed
Close
,
Sergio Abonante Regional Hospital, Cosenza, Italy

Search for other papers by Sergio Abonante in
Google Scholar
PubMed
Close
,
Francesco Romeo Regional Hospital, Cosenza, Italy

Search for other papers by Francesco Romeo in
Google Scholar
PubMed
Close
,
Vincenzo Pezzi Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy

Search for other papers by Vincenzo Pezzi in
Google Scholar
PubMed
Close
,
Antonino Belfiore Endocrinology, Department of Health, University Magna Graecia of Catanzaro, Catanzaro, Italy

Search for other papers by Antonino Belfiore in
Google Scholar
PubMed
Close
, and
Marcello Maggiolini Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy

Search for other papers by Marcello Maggiolini in
Google Scholar
PubMed
Close
Free access
Paola De Marco
Search for other papers by Paola De Marco in
Google Scholar
PubMed
Close
,
Enrica Romeo
Search for other papers by Enrica Romeo in
Google Scholar
PubMed
Close
,
Adele Vivacqua
Search for other papers by Adele Vivacqua in
Google Scholar
PubMed
Close
,
Roberta Malaguarnera Department of Pharmacy Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy

Regional Hospital Cosenza, Italy

Endocrinology Department of Health, University Magna Graecia of Catanzaro, Catanzaro, Italy

Search for other papers by Roberta Malaguarnera in
Google Scholar
PubMed
Close
,
Sergio Abonante Department of Pharmacy Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy

Regional Hospital Cosenza, Italy

Endocrinology Department of Health, University Magna Graecia of Catanzaro, Catanzaro, Italy

Search for other papers by Sergio Abonante in
Google Scholar
PubMed
Close
,
Francesco Romeo Department of Pharmacy Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy

Regional Hospital Cosenza, Italy

Endocrinology Department of Health, University Magna Graecia of Catanzaro, Catanzaro, Italy

Search for other papers by Francesco Romeo in
Google Scholar
PubMed
Close
,
Vincenzo Pezzi
Search for other papers by Vincenzo Pezzi in
Google Scholar
PubMed
Close
,
Antonino Belfiore Department of Pharmacy Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy

Regional Hospital Cosenza, Italy

Endocrinology Department of Health, University Magna Graecia of Catanzaro, Catanzaro, Italy

Search for other papers by Antonino Belfiore in
Google Scholar
PubMed
Close
, and
Marcello Maggiolini
Search for other papers by Marcello Maggiolini in
Google Scholar
PubMed
Close

Elevated insulin levels have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes characterized by a poor prognosis. Insulin stimulates the proliferation, migration, and invasiveness of cancer cells through diverse transduction pathways, including estrogen signaling. As G protein estrogen receptor 1 (GPER1) mediates rapid cell responses to estrogens, we evaluated the potential of insulin to regulate GPER1 expression and function in leiomyosarcoma cancer cells (SKUT-1) and breast cancer-associated fibroblasts (CAFs), which were used as a model system. We found that insulin transactivates the GPER1 promoter sequence and increases the mRNA and protein expression of GPER1 through the activation of the PRKCD/MAPK1/c-Fos/AP1 transduction pathway, as ascertained by means of specific pharmacological inhibitors and gene-silencing experiments. Moreover, cell migration triggered by insulin occurred through GPER1 and its main target gene CTGF, whereas the insulin-induced expression of GPER1 boosted cell-cycle progression and the glucose uptake stimulated by estrogens. Notably, a positive correlation between insulin serum levels and GPER1 expression was found in cancer fibroblasts obtained from breast cancer patients. Altogether, our data indicate that GPER1 may be included among the complex network of transduction signaling triggered by insulin that drives cells toward cancer progression.

Free access