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Shane Stegeman School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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Leire Moya School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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Luke A Selth School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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Amanda B Spurdle School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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Judith A Clements School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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Jyotsna Batra School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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The oncogene MDM4, also known as MDMX or HDMX, contributes to cancer susceptibility and progression through its capacity to negatively regulate a range of genes with tumour-suppressive functions. As part of a recent genome-wide association study it was determined that the A-allele of the rs4245739 SNP (A>C), located in the 3′-UTR of MDM4, is associated with an increased risk of prostate cancer. Computational predictions revealed that the rs4245739 SNP is located within a predicted binding site for three microRNAs (miRNAs): miR-191-5p, miR-887 and miR-3669. Herein, we show using reporter gene assays and endogenous MDM4 expression analyses that miR-191-5p and miR-887 have a specific affinity for the rs4245739 SNP C-allele in prostate cancer. These miRNAs do not affect MDM4 mRNA levels, rather they inhibit its translation in C-allele-containing PC3 cells but not in LNCaP cells homozygous for the A-allele. By analysing gene expression datasets from patient cohorts, we found that MDM4 is associated with metastasis and prostate cancer progression and that targeting this gene with miR-191-5p or miR-887 decreases in PC3 cell viability. This study is the first, to our knowledge, to demonstrate regulation of the MDM4 rs4245739 SNP C-allele by two miRNAs in prostate cancer, and thereby to identify a mechanism by which the MDM4 rs4245739 SNP A-allele may be associated with an increased risk for prostate cancer.

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Tracy A O'Mara Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Dylan M Glubb Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jodie N Painter Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Timothy Cheng Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Joe Dennis Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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The Australian National Endometrial Cancer Study Group (ANECS) Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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John Attia Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Elizabeth G Holliday Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Mark McEvoy Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Rodney J Scott Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Katie Ashton Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Tony Proietto Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Geoffrey Otton Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Mitul Shah Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Shahana Ahmed Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Catherine S Healey Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Maggie Gorman Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Lynn Martin Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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National Study of Endometrial Cancer Genetics Group (NSECG) Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Shirley Hodgson Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Peter A Fasching Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Alexander Hein Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Matthias W Beckmann Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Arif B Ekici Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Per Hall Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Kamila Czene Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hatef Darabi Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jingmei Li Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Matthias Dürst Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Ingo Runnebaum Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Peter Hillemanns Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Thilo Dörk Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Diether Lambrechts Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jeroen Depreeuw Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Daniela Annibali Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Frederic Amant Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hui Zhao Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Ellen L Goode Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Sean C Dowdy Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Brooke L Fridley Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Stacey J Winham Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Helga B Salvesen Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Tormund S Njølstad Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jone Trovik Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Henrica M J Werner Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Emma Tham Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Tao Liu Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Miriam Mints Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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RENDOCAS Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Manjeet K Bolla Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Kyriaki Michailidou Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jonathan P Tyrer Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Qin Wang Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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John L Hopper Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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AOCS Group Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Julian Peto Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Anthony J Swerdlow Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Barbara Burwinkel Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hermann Brenner Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Alfons Meindl Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hiltrud Brauch Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Annika Lindblom Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jenny Chang-Claude Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Fergus J Couch Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Graham G Giles Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Vessela N Kristensen Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Angela Cox Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Paul D P Pharoah Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Alison M Dunning Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Ian Tomlinson Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Douglas F Easton Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Deborah J Thompson Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Amanda B Spurdle Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Excessive exposure to estrogen is a well-established risk factor for endometrial cancer (EC), particularly for cancers of endometrioid histology. The physiological function of estrogen is primarily mediated by estrogen receptor alpha, encoded by ESR1. Consequently, several studies have investigated whether variation at the ESR1 locus is associated with risk of EC, with conflicting results. We performed comprehensive fine-mapping analyses of 3633 genotyped and imputed single nucleotide polymorphisms (SNPs) in 6607 EC cases and 37 925 controls. There was evidence of an EC risk signal located at a potential alternative promoter of the ESR1 gene (lead SNP rs79575945, P=1.86×10−5), which was stronger for cancers of endometrioid subtype (P=3.76×10−6). Bioinformatic analysis suggests that this risk signal is in a functionally important region targeting ESR1, and eQTL analysis found that rs79575945 was associated with expression of SYNE1, a neighbouring gene. In summary, we have identified a single EC risk signal located at ESR1, at study-wide significance. Given SNPs located at this locus have been associated with risk for breast cancer, also a hormonally driven cancer, this study adds weight to the rationale for performing informed candidate fine-scale genetic studies across cancer types.

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Deborah J Thompson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tracy A O'Mara Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Dylan M Glubb Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jodie N Painter Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Timothy Cheng Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Elizabeth Folkerd Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Deborah Doody Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Joe Dennis Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Penelope M Webb Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the Australian National Endometrial Cancer Study Group (ANECS) Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Maggie Gorman Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Lynn Martin Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Shirley Hodgson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the National Study of Endometrial Cancer Genetics Group (NSECG) Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kyriaki Michailidou Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jonathan P Tyrer Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mel J Maranian Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Per Hall Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kamila Czene Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hatef Darabi Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jingmei Li Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Peter A Fasching Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alexander Hein Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias W Beckmann Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Arif B Ekici Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Thilo Dörk Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Peter Hillemanns Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias Dürst Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ingo Runnebaum Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hui Zhao Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jeroen Depreeuw Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stefanie Schrauwen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Frederic Amant Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ellen L Goode Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Brooke L Fridley Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Sean C Dowdy Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stacey J Winham Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Helga B Salvesen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jone Trovik Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tormund S Njolstad Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Henrica M J Werner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Katie Ashton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tony Proietto Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Geoffrey Otton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Luis Carvajal-Carmona Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Emma Tham Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tao Liu Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Miriam Mints Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for RENDOCAS Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Rodney J Scott Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mark McEvoy Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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John Attia Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Elizabeth G Holliday Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Grant W Montgomery Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Nicholas G Martin Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Dale R Nyholt Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Anjali K Henders Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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John L Hopper Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Nadia Traficante Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the AOCS Group Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias Ruebner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Anthony J Swerdlow Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Barbara Burwinkel Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hermann Brenner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alfons Meindl Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hiltrud Brauch Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Annika Lindblom Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Diether Lambrechts Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jenny Chang-Claude Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Fergus J Couch Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Graham G Giles Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Vessela N Kristensen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Angela Cox Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Manjeet K Bolla Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Qin Wang Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stig E Bojesen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mitul Shah Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Robert Luben Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kay-Tee Khaw Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Paul D P Pharoah Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alison M Dunning Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ian Tomlinson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mitch Dowsett Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Douglas F Easton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Amanda B Spurdle Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and with estradiol (E2) concentrations. We analyzed 2937 single nucleotide polymorphisms (SNPs) in 6608 endometrial cancer cases and 37 925 controls and report the first genome wide-significant association between endometrial cancer and a CYP19A1 SNP (rs727479 in intron 2, P=4.8×10−11). SNP rs727479 was also among those most strongly associated with circulating E2 concentrations in 2767 post-menopausal controls (P=7.4×10−8). The observed endometrial cancer odds ratio per rs727479 A-allele (1.15, CI=1.11–1.21) is compatible with that predicted by the observed effect on E2 concentrations (1.09, CI=1.03–1.21), consistent with the hypothesis that endometrial cancer risk is driven by E2. From 28 candidate-causal SNPs, 12 co-located with three putative gene-regulatory elements and their risk alleles associated with higher CYP19A1 expression in bioinformatical analyses. For both phenotypes, the associations with rs727479 were stronger among women with a higher BMI (P interaction=0.034 and 0.066 respectively), suggesting a biologically plausible gene-environment interaction.

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