Search Results

You are looking at 1 - 1 of 1 items for

  • Author: Ana Irigaray Echarri x
  • Refine by access: All content x
Clear All Modify Search
Marta Araujo-Castro Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Madrid, Spain & Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain

Search for other papers by Marta Araujo-Castro in
Google Scholar
PubMed
Close
,
Betina Biagetti Department of Endocrinology and Nutrition, Hospital Universitario Vall de Hebrón, CIBERER U747 (ISCIII), ENDO-ERN, Barcelona, Spain

Search for other papers by Betina Biagetti in
Google Scholar
PubMed
Close
,
Edelmiro Menéndez Torre Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias & Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Asturias, Spain

Search for other papers by Edelmiro Menéndez Torre in
Google Scholar
PubMed
Close
,
Iría Novoa-Testa Department of Endocrinology and Nutrition, Hospital Universitario de A Coruña, A Coruña, Spain

Search for other papers by Iría Novoa-Testa in
Google Scholar
PubMed
Close
,
Fernando Cordido Department of Endocrinology and Nutrition, Hospital Universitario de A Coruña, A Coruña, Spain

Search for other papers by Fernando Cordido in
Google Scholar
PubMed
Close
,
Eider Pascual-Corrales Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Madrid, Spain & Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain

Search for other papers by Eider Pascual-Corrales in
Google Scholar
PubMed
Close
,
Víctor Rodríguez Berrocal Department of Neurosurgery, Hospital Universitario Ramón y Cajal, Madrid, Spain

Search for other papers by Víctor Rodríguez Berrocal in
Google Scholar
PubMed
Close
,
Fernando Guerrero-Pérez Department of Endocrinology and Nutrition, Hospital Universitario de Bellvitge, Cataluña L’Hospitalet de Llobregat, Spain

Search for other papers by Fernando Guerrero-Pérez in
Google Scholar
PubMed
Close
,
Almudena Vicente Department of Endocrinology and Nutrition, Hospital Universitario de Toledo, Toledo, Spain

Search for other papers by Almudena Vicente in
Google Scholar
PubMed
Close
,
Juan Carlos Percovich Hualpa Department of Endocrinology and Nutrition, Hospital Universitario Gregorio Marañón, Madrid, Spain

Search for other papers by Juan Carlos Percovich Hualpa in
Google Scholar
PubMed
Close
,
Rogelio García-Centeno Department of Endocrinology and Nutrition, Hospital Universitario Gregorio Marañón, Madrid, Spain

Search for other papers by Rogelio García-Centeno in
Google Scholar
PubMed
Close
,
Laura González-Fernández Department of Endocrinology and Nutrition, Hospital Universitario Gregorio Marañón, Madrid, Spain

Search for other papers by Laura González-Fernández in
Google Scholar
PubMed
Close
,
María Dolores Ollero García Department of Endocrinology and Nutrition, Hospital Universitario Navarra, Pamplona, Spain

Search for other papers by María Dolores Ollero García in
Google Scholar
PubMed
Close
,
Ana Irigaray Echarri Department of Endocrinology and Nutrition, Hospital Universitario Navarra, Pamplona, Spain

Search for other papers by Ana Irigaray Echarri in
Google Scholar
PubMed
Close
,
María Dolores Moure Rodríguez Department Endocrinology and Nutrition, Hospital Universitario de Cruces, Bilbao, Spain

Search for other papers by María Dolores Moure Rodríguez in
Google Scholar
PubMed
Close
,
Cristina Novo-Rodríguez Department of Endocrinology and Nutrition, Hospital Universitario Virgen de las Nieves, Granada, Spain

Search for other papers by Cristina Novo-Rodríguez in
Google Scholar
PubMed
Close
,
María Calatayud Department of Endocrinology and Nutrition, Hospital Universitario Doce de Octubre, Madrid, Spain

Search for other papers by María Calatayud in
Google Scholar
PubMed
Close
,
Rocío Villar-Taibo Department of Endocrinology and Nutrition, Hospital Universitario de Santiago de Compostela, Madrid, Spain

Search for other papers by Rocío Villar-Taibo in
Google Scholar
PubMed
Close
,
Ignacio Bernabéu Department of Endocrinology and Nutrition, Hospital Universitario de Santiago de Compostela, Madrid, Spain

Search for other papers by Ignacio Bernabéu in
Google Scholar
PubMed
Close
,
Cristina Alvarez-Escola Department of Endocrinology and Nutrition, Hospital Universitario La Paz, Madrid, Spain

Search for other papers by Cristina Alvarez-Escola in
Google Scholar
PubMed
Close
,
Pamela Benítez Valderrama Department of Endocrinology and Nutrition, Hospital Universitario La Paz, Madrid, Spain

Search for other papers by Pamela Benítez Valderrama in
Google Scholar
PubMed
Close
,
Carmen Tenorio-Jiménez Department of Endocrinology and Nutrition, Hospital Universitario Virgen de las Nieves, Granada, Spain

Search for other papers by Carmen Tenorio-Jiménez in
Google Scholar
PubMed
Close
,
Pablo Abellán Galiana Department of Endocrinology and Nutrition, Hospital General Universitario de Castellón, Castellón, Spain
Department of Medicine and Surgery, Universidad Cardenal Herrera-CEU, CEU Universities, Castellón, Spain

Search for other papers by Pablo Abellán Galiana in
Google Scholar
PubMed
Close
,
Eva Venegas Department of Endocrinology and Nutrition, Hospital Universitario Virgen del Rocío, Sevilla, Spain

Search for other papers by Eva Venegas in
Google Scholar
PubMed
Close
,
Inmaculada González-Molero Endocrinology and Nutrition Department, Hospital Regional Universitario de Málaga, IBIMA Plataforma Bionand, Málaga, Spain

Search for other papers by Inmaculada González-Molero in
Google Scholar
PubMed
Close
,
Pedro Iglesias Department of Endocrinology and Nutrition, Hospital Universitario Puerta de Hierro, Madrid, Spain

Search for other papers by Pedro Iglesias in
Google Scholar
PubMed
Close
,
Concepción Blanco-Carrera Department of Endocrinology and Nutrition, Hospital Universitario Príncipe de Asturias, Madrid, Spain

Search for other papers by Concepción Blanco-Carrera in
Google Scholar
PubMed
Close
,
Fernando Vidal-Ostos De Lara Department of Endocrinology and Nutrition, Hospital Universitario Príncipe de Asturias, Madrid, Spain

Search for other papers by Fernando Vidal-Ostos De Lara in
Google Scholar
PubMed
Close
,
Paz de Miguel Novoa Department of Endocrinology and Nutrition, Hospital Clínico San Carlos, Madrid, Spain

Search for other papers by Paz de Miguel Novoa in
Google Scholar
PubMed
Close
,
Elena López Mezquita Department of Endocrinology and Nutrition, Hospital Universitario Clínico San Cecilio, Granada, Spain

Search for other papers by Elena López Mezquita in
Google Scholar
PubMed
Close
,
Felicia Alexandra Hanzu Department of Endocrinology and Nutrition, Hospital Clinic de Barcelona, Barcelona, Spain

Search for other papers by Felicia Alexandra Hanzu in
Google Scholar
PubMed
Close
,
Iban Aldecoa Biomedical Diagnostic Center, Department of Pathology, Hospital Clinic - University of Barcelona, Barcelona, Spain
Neurological Tissue Bank of the Biobank, FCRB-IDIBAPS-Hospital Clinic Barcelona, Barcelona, Spain

Search for other papers by Iban Aldecoa in
Google Scholar
PubMed
Close
,
Silvia Aznar Department of Endocrinology and Nutrition, Hospital Universitario De Albacete, Albacete, Spain

Search for other papers by Silvia Aznar in
Google Scholar
PubMed
Close
,
Cristina Lamas Department of Endocrinology and Nutrition, Hospital Universitario De Albacete, Albacete, Spain

Search for other papers by Cristina Lamas in
Google Scholar
PubMed
Close
,
Anna Aulinas Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, IR-SANT PAU, CIBERER U747 (ISCIII), Barcelona, Spain
Department of Medicine, Universitat de Vic-Universitat Central de Catalunya, Vic, Spain

Search for other papers by Anna Aulinas in
Google Scholar
PubMed
Close
,
Queralt Asla Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, IR-SANT PAU, CIBERER U747 (ISCIII), Barcelona, Spain
Department of Medicine, Universitat de Vic-Universitat Central de Catalunya, Vic, Spain

Search for other papers by Queralt Asla in
Google Scholar
PubMed
Close
,
Paola Gracia Gimeno Department of Endocrinology and Nutrition, Hospital Royo Villanova, Zaragoza, Spain

Search for other papers by Paola Gracia Gimeno in
Google Scholar
PubMed
Close
,
José María Recio-Córdova Department of Endocrinology and Nutrition, Hospital Royo Villanova, Zaragoza, Spain

Search for other papers by José María Recio-Córdova in
Google Scholar
PubMed
Close
,
María Dolores Avilés-Pérez Department of Endocrinology and Nutrition, Hospital Universitario Clínico San Cecilio, Granada, Spain

Search for other papers by María Dolores Avilés-Pérez in
Google Scholar
PubMed
Close
,
Diego Asensio-Wandosell Department of Endocrinology and Nutrition, Hospital Universitario Germans Trias i Pujol, Cataluña, Spain

Search for other papers by Diego Asensio-Wandosell in
Google Scholar
PubMed
Close
,
Miguel Sampedro-Núñez Department of Endocrinology and Nutrition, Hospital Universitario La Princesa Madrid, Spain

Search for other papers by Miguel Sampedro-Núñez in
Google Scholar
PubMed
Close
,
Rosa Cámara Department of Endocrinology and Nutrition, Hospital Universitario y Politécnico La Fe, Valencia, Spain

Search for other papers by Rosa Cámara in
Google Scholar
PubMed
Close
,
Miguel Paja Fano Department of Endocrinology and Nutrition, OSI Bilbao-Basurto, Hospital Universitario de Basurto & University of the Basque Country UPV/EHU, Bilbao, Spain

Search for other papers by Miguel Paja Fano in
Google Scholar
PubMed
Close
,
Ignacio Ruz-Caracuel Department of Pathology, Hospital Universitario Ramón y Cajal, IRYCIS & CIBER Cáncer (CIBERONC), Madrid, Spain

Search for other papers by Ignacio Ruz-Caracuel in
Google Scholar
PubMed
Close
,
Carmen Fajardo Department of Endocrinology and Nutrition, Hospital Universitario La Ribera, Valencia, Spain

Search for other papers by Carmen Fajardo in
Google Scholar
PubMed
Close
,
Mónica Marazuela Department of Endocrinology and Nutrition, Hospital Universitario La Princesa Madrid, Spain

Search for other papers by Mónica Marazuela in
Google Scholar
PubMed
Close
, and
Manel Puig-Domingo Department of Endocrinology and Nutrition, Hospital Universitario Germans Trias i Pujol, Cataluña, Spain

Search for other papers by Manel Puig-Domingo in
Google Scholar
PubMed
Close

The objective of the study was to evaluate the efficacy of second-line therapies in patients with acromegaly caused by a growth hormone (GH) and prolactin (PRL) co-secreting pituitary neuroendocrine tumor (GH&PRL-Pit-NET) compared to their efficacy in patients with acromegaly caused by a GH-secreting pituitary neuroendocrine tumor (GH-Pit-NET). This is a multicenter retrospective study of patients with acromegaly on treatment with pasireotide and/or pegvisomant. Patients were classified in two groups: GH&PRL-Pit-NETs when evidence of hyperprolactinemia and immunohistochemistry (IHC) for GH and PRL was positive or if PRL were >200 ng/dL regardless of the PRL-IHC and GH-Pit-NETs when the previously mentioned criteria were not met. A total of 28 cases with GH&PRL-Pit-NETs and 122 with GH-Pit-NETs met the inclusion criteria. GH&PRL-Pit-NETs presented at a younger age, caused hypopituitarism, and were invasive more frequently than GH-Pit-NETs. There were 124 patients treated with pegvisomant and 49 with pasireotide at any time. The efficacy of pegvisomant for IGF-1 normalization was of 81.5% and of pasireotide of 71.4%. No differences in IGF-1 control with pasireotide and with pegvisomant were observed between GH&PRL-Pit-NETs and GH-Pit-NETs. All GH&PRL-Pit-NET cases treated with pasireotide (n = 6) and 82.6% (n = 19/23) of the cases treated with pegvisomant normalized PRL levels. No differences in the rate of IGF-1 control between pegvisomant and pasireotide were detected in patients with GH&PRL-Pit-NETs (84.9% vs 66.7%, P = 0.178). We conclude that despite the more aggressive behavior of GH&PRL-Pit-NETs than GH-Pit-NETs, no differences in the rate of IGF-1 control with pegvisomant and pasireotide were observed between both groups, and both drugs have shown to be effective treatments to control IGF-1 and PRL hypersecretion in these tumors.

Restricted access