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Qi-Chang Wan and Bin Ji

We read with interest the article by Rosario et al., which summarized the practical applicability of accessible imaging method in the management of thyroid nodules with indeterminate cytologically (TNIC) (Rosario, et al. 2021). For 18F-FDG-PET, it was stated that “a nodule characterized by low or absent 18F-FDG uptake is considered at a very low risk of malignance”, and “thyroidectomy can be excluded if these tests suggest benignity”. We respectfully want to share a different opinion based on our previous work.