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Giorgio Grani Unit of Endocrinology, Department of Experimental Medicine, ‘Sapienza’ Università di Roma, V.le Regina Elena, 324, 00161 Rome, Italy

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Angela Nesca Unit of Endocrinology, Department of Experimental Medicine, ‘Sapienza’ Università di Roma, V.le Regina Elena, 324, 00161 Rome, Italy

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Marianna Del Sordo Unit of Endocrinology, Department of Experimental Medicine, ‘Sapienza’ Università di Roma, V.le Regina Elena, 324, 00161 Rome, Italy

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Anna Calvanese Unit of Endocrinology, Department of Experimental Medicine, ‘Sapienza’ Università di Roma, V.le Regina Elena, 324, 00161 Rome, Italy

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Giovanni Carbotta Unit of Endocrinology, Department of Experimental Medicine, ‘Sapienza’ Università di Roma, V.le Regina Elena, 324, 00161 Rome, Italy

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Marta Bianchini Unit of Endocrinology, Department of Experimental Medicine, ‘Sapienza’ Università di Roma, V.le Regina Elena, 324, 00161 Rome, Italy

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Angela Fumarola Unit of Endocrinology, Department of Experimental Medicine, ‘Sapienza’ Università di Roma, V.le Regina Elena, 324, 00161 Rome, Italy

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Calcitonin (CT) is an important clinical marker for the diagnosis and follow-up of medullary thyroid carcinoma, although it is not absolutely specific. Some authors have reported C-cell hyperplasia in a number of thyroid specimens affected by Hashimoto's thyroiditis. The association between thyroiditis and hypercalcitoninemia is still controversial because some authors have reported low CT levels. The aim of this study is to evaluate the basal CT values in patients with and without thyroid autoimmunity. From May 2005 to February 2010, 1073 patients underwent ultrasonography-guided fine-needle aspiration cytology at the Thyroid Center of Sapienza University of Rome, with evaluation of basal serum FT4, FT3, TSH, and antithyroid peroxidase (anti-TPO) antibodies as well as CT levels. Forty-one patients presented a basal CT level above the reference upper limit. The mean serum CT was significantly lower in women than in men (4.28±6.63 vs 7.50±25.50 pg/ml; P<0.01). Basal serum CT was not significantly higher in patients showing anti-TPO Ab positivity (4.71±6.46 vs 4.84±13.11 pg/ml; P>0.05). Importantly, the rate of ‘suspicious’ CT values (above the 10 pg/ml cutoff) was not significantly different between patients with or without thyroid autoimmunity (3.9 vs 3.0%). Patients with hypercalcitoninemia suffering from chronic autoimmune thyroiditis should undergo the same clinical evaluation procedure as patients do without thyroid autoimmunity.

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Livia Lamartina Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma Sapienza, Roma, Italy

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Giorgio Grani Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma Sapienza, Roma, Italy

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Emanuela Arvat Dipartimento di Scienze Mediche, Università di Torino, Torino, Italy

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Alice Nervo Dipartimento di Scienze Mediche, Università di Torino, Torino, Italy

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Maria Chiara Zatelli Unità Operativa di Endocrinologia e Malattie del Ricambio, Azienda Ospedaliera Universitaria di Ferrara, Ferrara, Italy

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Roberta Rossi Unità Operativa di Endocrinologia e Malattie del Ricambio, Azienda Ospedaliera Universitaria di Ferrara, Ferrara, Italy

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Efisio Puxeddu Dipartimento di Medicina, Università di Perugia, Perugia, Italy

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Silvia Morelli Dipartimento di Medicina, Università di Perugia, Perugia, Italy

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Massimo Torlontano Dipartimento di Scienze Mediche, Ospedale Casa Sollievo della Sofferenza-IRCCS, San Giovanni Rotondo, Italy

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Michela Massa Dipartimento di Scienze Mediche, Ospedale Casa Sollievo della Sofferenza-IRCCS, San Giovanni Rotondo, Italy

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Rocco Bellantone Cattedra di Chirurgia Endocrina, Area di Endocrinologia e Malattie Metaboliche, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy

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Alfredo Pontecorvi Cattedra di Endocrinologia, Area di Endocrinologia e Malattie Metaboliche, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy

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Teresa Montesano Unità di Medicina Nucleare, Università di Roma Sapienza, Roma, Italy

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Loredana Pagano Unità di Endocrinologia, Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale, Novara, Italy

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Lorenzo Daniele Unità di Patologia, Ospedale Mauriziano Umberto I di Torino, Torino, Italy

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Laura Fugazzola Divisione di Malattie Endocrine e Metaboliche, Istituto Auxologico Italiano IRCCS, Milano, Italy
Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy

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Graziano Ceresini Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy

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Rocco Bruno Unità di Endocrinologia, Ospedale di Tinchi-Pisticci, Matera, Italy

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Ruth Rossetto Divisione di Endocrinologia, Diabetologia e Metabolismo, Dipartimento di Scienze Mediche, Ospedale Molinette, A.O.U. Città della Salute e della Scienza di Torino, Università di Torino, Torino, Italy

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Salvatore Tumino Dipartimento di Medicina Clinica e Sperimentale, Università di Catania, Catania, Italy

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Marco Centanni Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Università di Roma Sapienza, Latina, Italia

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Domenico Meringolo Unità Operativa Semplice Dipartimentale, Ospedale Bentivoglio, Ausl Bologna, Bologna, Italy

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Maria Grazia Castagna Dipartimento di Scienze Mediche, Chirurgiche e Neurologiche, Università di Siena, Siena, Italy

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Domenico Salvatore Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli ‘Federico II’, Napoli, Italy

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Antonio Nicolucci Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy

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Giuseppe Lucisano Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy

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Sebastiano Filetti Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma Sapienza, Roma, Italy

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Cosimo Durante Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma Sapienza, Roma, Italy

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