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Eric Monsalves
Eric Monsalves
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Kyle Juraschka
Kyle Juraschka
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Toru Tateno
Toru Tateno
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Sameer Agnihotri
Sameer Agnihotri
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Sylvia L Asa
Sylvia L Asa
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Shereen Ezzat
Shereen Ezzat
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Gelareh Zadeh
Gelareh Zadeh
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Pituitary adenomas are common intracranial neoplasms. Patients with these tumors exhibit a wide range of clinically challenging problems, stemming either from results of sellar mass effect in pituitary macroadenoma or the diverse effects of aberrant hormone production by adenoma cells. While some patients are cured/controlled by surgical resection and/or medical therapy, a proportion of patients exhibit tumors that are refractory to current modalities. New therapeutic approaches are needed for these patients. Activation of the AKT/phophotidylinositide-3-kinase pathway, including mTOR activation, is common in human neoplasia, and a number of therapeutic approaches are being employed to neutralize activation of this pathway in human cancer. This review examines the role of this pathway in pituitary tumors with respect to tumor biology and its potential role as a therapeutic target.
