Search Results

You are looking at 1 - 2 of 2 items for

  • Author: Michela Perrino x
  • Refine by access: All content x
Clear All Modify Search
Michela Perrino Endocrine-Diabetological Unit, Endocrine Surgery Unit, Nuclear Medicine Unit, Department of Medical Sciences, University of Milan

Search for other papers by Michela Perrino in
Google Scholar
PubMed
Close
,
Guia Vannucchi Endocrine-Diabetological Unit, Endocrine Surgery Unit, Nuclear Medicine Unit, Department of Medical Sciences, University of Milan

Search for other papers by Guia Vannucchi in
Google Scholar
PubMed
Close
,
Leonardo Vicentini Endocrine-Diabetological Unit, Endocrine Surgery Unit, Nuclear Medicine Unit, Department of Medical Sciences, University of Milan

Search for other papers by Leonardo Vicentini in
Google Scholar
PubMed
Close
,
Gianmaria Cantoni Endocrine-Diabetological Unit, Endocrine Surgery Unit, Nuclear Medicine Unit, Department of Medical Sciences, University of Milan

Search for other papers by Gianmaria Cantoni in
Google Scholar
PubMed
Close
,
Davide Dazzi Endocrine-Diabetological Unit, Endocrine Surgery Unit, Nuclear Medicine Unit, Department of Medical Sciences, University of Milan

Search for other papers by Davide Dazzi in
Google Scholar
PubMed
Close
,
Carla Colombo Endocrine-Diabetological Unit, Endocrine Surgery Unit, Nuclear Medicine Unit, Department of Medical Sciences, University of Milan

Search for other papers by Carla Colombo in
Google Scholar
PubMed
Close
,
Marcello Rodari Endocrine-Diabetological Unit, Endocrine Surgery Unit, Nuclear Medicine Unit, Department of Medical Sciences, University of Milan

Search for other papers by Marcello Rodari in
Google Scholar
PubMed
Close
,
Arturo Chiti Endocrine-Diabetological Unit, Endocrine Surgery Unit, Nuclear Medicine Unit, Department of Medical Sciences, University of Milan

Search for other papers by Arturo Chiti in
Google Scholar
PubMed
Close
,
Paolo Beck-Peccoz Endocrine-Diabetological Unit, Endocrine Surgery Unit, Nuclear Medicine Unit, Department of Medical Sciences, University of Milan

Search for other papers by Paolo Beck-Peccoz in
Google Scholar
PubMed
Close
, and
Laura Fugazzola Endocrine-Diabetological Unit, Endocrine Surgery Unit, Nuclear Medicine Unit, Department of Medical Sciences, University of Milan

Search for other papers by Laura Fugazzola in
Google Scholar
PubMed
Close

The incidence of papillary thyroid cancer (PTC) is rapidly growing, the recorded increase being mainly related to tumors ≤2 cm. The re-classification of tumors >1 and ≤2 cm limited to the thyroid from the T2 to the T1 category triggered some concerns about their best management. In order to identify possible predictors of disease outcome, several clinico-pathological features were analyzed by uni- and multivariate analyses in a retrospective consecutive series of 251 PTCs ≤2 cm. Moreover, since 37% of cases were submitted to prophylactic central compartment node dissection (CLND, VI–VII levels) and radioiodine ablation was performed only when the tumor had an extrathyroidal extension, the impact of these therapeutic tools on the final outcome was evaluated. Among all outcome predictors analyzed, only lymph node metastases and extracapsular invasion were strongly associated with persistence/recurrence. It is worth noting that neither age nor tumor size was a significant indicator of the outcome. Interestingly, as far as the therapeutic interventions are concerned, CLND was strongly associated with remission, whereas radioiodine ablation did not influence the outcome. In conclusion, present results confirm the prognostic influence of node metastases and extra-thyroidal invasion, indicating the need for aggressive treatment in tumors extending beyond the capsule. On the contrary, all pT1N0 tumors, regardless of the diameter, the number of intrathyroidal foci, and the age can be effectively treated only by surgery. The major impact of prophylactic CLND on prognosis suggests to routinely associate it to total thyroidectomy in cases with a preoperative diagnosis of malignancy.

Free access
Simone De Leo Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Simone De Leo in
Google Scholar
PubMed
Close
,
Michela Perrino Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Michela Perrino in
Google Scholar
PubMed
Close
,
Sara Badiali Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Sara Badiali in
Google Scholar
PubMed
Close
,
Stefania Rossi Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Stefania Rossi in
Google Scholar
PubMed
Close
,
Valentina Cirello Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Valentina Cirello in
Google Scholar
PubMed
Close
,
Carla Colombo Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Carla Colombo in
Google Scholar
PubMed
Close
,
Delfina Tosi Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Delfina Tosi in
Google Scholar
PubMed
Close
,
Gianmaria Cantoni Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Gianmaria Cantoni in
Google Scholar
PubMed
Close
,
Luca Poggi Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Luca Poggi in
Google Scholar
PubMed
Close
,
Gaetano Bulfamante Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy
Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Gaetano Bulfamante in
Google Scholar
PubMed
Close
,
Paolo Beck-Peccoz Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy
Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Paolo Beck-Peccoz in
Google Scholar
PubMed
Close
,
Leonardo Vicentini Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Leonardo Vicentini in
Google Scholar
PubMed
Close
, and
Laura Fugazzola Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy
Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

Search for other papers by Laura Fugazzola in
Google Scholar
PubMed
Close
Free access