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Paul Benjamin Loughrey Patrick G Johnston Centre for Cancer Research, Queen’s University, Belfast, UK
Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Federico Roncaroli Geoffrey Jefferson Brain Research Centre, Division of Neuroscience and Experimental Psychology, School of Medicine, Manchester University, Manchester, UK

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Estelle Healy Department of Cellular Pathology, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Philip Weir Department of Neurosurgery, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Madhu Basetti Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Ruth T Casey Department of Endocrinology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK

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Steven J Hunter Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Pituitary neuroendocrine tumours (PitNETs) associated with paragangliomas or phaeochromocytomas are rare. SDHx variants are estimated to be associated with 0.3–1.8% of PitNETs. Only a few case reports have documented the association with MAX variants. Prolactinomas are the most common PitNETs occurring in patients with SDHx variants, followed by somatotrophinomas, clinically non-functioning tumours and corticotrophinomas. One pituitary carcinoma has been described. SDHC, SDHB and SDHA mutations are inherited in an autosomal dominant fashion and tumorigenesis seems to adhere to Knudson’s two-hit hypothesis. SDHD and SDHAF2 mutations most commonly have paternal inheritance. Immunohistochemistry for SDHB or MAX and loss of heterozygosity analysis can support the assessment of pathogenicity of the variants. Metabolomics is promising in the diagnosis of SDHx-related disease. Future research should aim to further clarify the role of SDHx and MAX variants or other genes in the molecular pathogenesis of PitNETs, including pseudohypoxic and kinase signalling pathways along with elucidating epigenetic mechanisms to predict tumour behaviour.

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Paul Benjamin Loughrey Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK
Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Brian Herron Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK

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Stephen Cooke Department of Neurosurgery, Belfast Health and Social Care Trust, Belfast, UK

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Philip Weir Department of Neurosurgery, Belfast Health and Social Care Trust, Belfast, UK

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Jayna Elizabeth Smyth Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Karen R Mullan Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Estelle G Healy Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK

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Jane Evanson Department of Radiology, Barts Health NHS Trust, London, UK

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Stephanie G Craig Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK

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Jacqueline A James Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK
Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK
Northern Ireland Biobank, Belfast Health and Social Care Trust, Belfast, UK

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Márta Korbonits Department of Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Steven J Hunter Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Cushing’s disease is a rare condition that occurs due to an adrenocorticotrophin-producing corticotrophinoma arising from the pituitary gland. The consequent hypercortisolaemia results in multisystem morbidity and mortality. This study aims to report incidence, clinicopathological characteristics, remission outcomes and mortality in a regional pituitary neurosurgical cohort of patients diagnosed with Cushing’s disease in Northern Ireland (NI) from 2000 to 2019. Clinical, biochemical and radiological data from a cohort of patients operated for Cushing’s disease were retrospectively collected and analysed. Fifty-three patients were identified, resulting in an estimated annual incidence of Cushing’s disease of 1.39–1.57 per million population per year. Females accounted for 72% (38/53) of the cohort. The majority (74%, 39/53) of corticotrophinomas were microadenomas and in 44% (17/39) of these no tumour was identified on preoperative magnetic resonance imaging. Histopathological characterisation was similarly difficult, with no tumour being identified in the histopathological specimen in 40% (21/53) of cases. Immediate postoperative remission rates were 53% and 66% when considering serum morning cortisol cut-offs of ≤ 50 nmol/L (1.8 µg/dL) and ≤ 138 nmol/L (5 µg/dL), respectively, in the week following pituitary surgery. Approximately 70% (37/53) of patients achieved longer-term remission with a single pituitary surgery. Three patients had recurrent disease. Patients with Cushing’s disease had a significantly higher mortality rate compared to the NI general population (standardised mortality ratio 8.10, 95% CI 3.3–16.7, P < 0.001). Annual incidence of Cushing’s disease in NI is consistent with other Northern European cohorts. Functioning corticotrophinomas are a clinically, radiologically and histopathologically elusive disease with increased mortality compared to the general population.

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Anja Rudolph Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Rebecca Hein Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Sara Lindström Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Lars Beckmann Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Sabine Behrens Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jianjun Liu Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Hugues Aschard Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Manjeet K Bolla Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jean Wang Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Thérèse Truong Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Emilie Cordina-Duverger Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Florence Menegaux Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Thomas Brüning Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Volker Harth Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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The GENICA Network Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Gianluca Severi Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Laura Baglietto Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Melissa Southey Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Stephen J Chanock Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jolanta Lissowska Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jonine D Figueroa Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Mikael Eriksson Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Keith Humpreys Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Hatef Darabi Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Janet E Olson Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Kristen N Stevens Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Celine M Vachon Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Julia A Knight Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Gord Glendon Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Anna Marie Mulligan Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Alan Ashworth Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Nicholas Orr Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Minouk Schoemaker Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Penny M Webb Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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kConFab Investigators Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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AOCS Management Group Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Pascal Guénel Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Hiltrud Brauch Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Graham Giles Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Montserrat García-Closas Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Kamila Czene Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Georgia Chenevix-Trench Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Fergus J Couch Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Irene L Andrulis Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Anthony Swerdlow Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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David J Hunter Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Dieter Flesch-Janys Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Douglas F Easton Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Per Hall Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Heli Nevanlinna Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Peter Kraft Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jenny Chang-Claude Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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on behalf of the Breast Cancer Association Consortium
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Women using menopausal hormone therapy (MHT) are at increased risk of developing breast cancer (BC). To detect genetic modifiers of the association between current use of MHT and BC risk, we conducted a meta-analysis of four genome-wide case-only studies followed by replication in 11 case–control studies. We used a case-only design to assess interactions between single-nucleotide polymorphisms (SNPs) and current MHT use on risk of overall and lobular BC. The discovery stage included 2920 cases (541 lobular) from four genome-wide association studies. The top 1391 SNPs showing P values for interaction (P int) <3.0×10−3 were selected for replication using pooled case–control data from 11 studies of the Breast Cancer Association Consortium, including 7689 cases (676 lobular) and 9266 controls. Fixed-effects meta-analysis was used to derive combined P int. No SNP reached genome-wide significance in either the discovery or combined stage. We observed effect modification of current MHT use on overall BC risk by two SNPs on chr13 near POMP (combined P int≤8.9×10−6), two SNPs in SLC25A21 (combined P int≤4.8×10−5), and three SNPs in PLCG2 (combined P int≤4.5×10−5). The association between lobular BC risk was potentially modified by one SNP in TMEFF2 (combined P int≤2.7×10−5), one SNP in CD80 (combined P int≤8.2×10−6), three SNPs on chr17 near TMEM132E (combined P int≤2.2×10−6), and two SNPs on chr18 near SLC25A52 (combined P int≤4.6×10−5). In conclusion, polymorphisms in genes related to solute transportation in mitochondria, transmembrane signaling, and immune cell activation are potentially modifying BC risk associated with current use of MHT. These findings warrant replication in independent studies.

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