Filter

Refine by collections

Refine by date

—

Refine by access

  • Print
  • Save

Search Results

You are looking at 1 - 10 of 291 items for :

  • Refine by access: All content x
Clear All
Pratima Basak Department of Immunology, Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5
Department of Immunology, Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5

Search for other papers by Pratima Basak in
Google Scholar
PubMed Close
,
Sumanta Chatterjee Department of Immunology, Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5
Department of Immunology, Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5

Search for other papers by Sumanta Chatterjee in
Google Scholar
PubMed Close
,
Steven Weger Department of Immunology, Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5

Search for other papers by Steven Weger in
Google Scholar
PubMed Close
,
M Christine Bruce Department of Immunology, Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5
Department of Immunology, Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5

Search for other papers by M Christine Bruce in
Google Scholar
PubMed Close
,
Leigh C Murphy Department of Immunology, Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5
Department of Immunology, Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5

Search for other papers by Leigh C Murphy in
Google Scholar
PubMed Close
, and
Afshin Raouf Department of Immunology, Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5
Department of Immunology, Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 471 Apotex Centre 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5

Search for other papers by Afshin Raouf in
Google Scholar
PubMed Close

Introduction Estrogen signaling through estrogen receptor α (ERα) is pivotal to the survival and maintenance of ERα + breast cancer tumors. Furthermore, the estrogen–ERα signaling axis has been shown to be indispensable to mammary gland development

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0105
Volume/Issue:
Volume 22: Issue 4
Open access
Eva Baxter Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Search for other papers by Eva Baxter in
Google Scholar
PubMed Close
,
Karolina Windloch Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Search for other papers by Karolina Windloch in
Google Scholar
PubMed Close
,
Greg Kelly Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Search for other papers by Greg Kelly in
Google Scholar
PubMed Close
,
Jason S Lee Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Search for other papers by Jason S Lee in
Google Scholar
PubMed Close
,
Frank Gannon Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Search for other papers by Frank Gannon in
Google Scholar
PubMed Close
, and
Donal J Brennan UCD School of Medicine, Catherine McAuley Research Centre, Mater Misericordiae University Hospital, Dublin, Ireland
Cancer Biology and Therapeutics Laboratory, UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland
Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

Search for other papers by Donal J Brennan in
Google Scholar
PubMed Close

( Carlson et al. 2014 ). Tamoxifen is a selective oestrogen receptor modulator, acting as an oestrogen receptor alpha (ERα) antagonist in the breast and as an agonist in the endometrium, increasing the risk of developing endometrial cancer ( Cohen 2004

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0563
Volume/Issue:
Volume 26: Issue 1
Free access
Hiroko Yamashita
Search for other papers by Hiroko Yamashita in
Google Scholar
PubMed Close
,
Mariko Nishio
Search for other papers by Mariko Nishio in
Google Scholar
PubMed Close
,
Tatsuya Toyama
Search for other papers by Tatsuya Toyama in
Google Scholar
PubMed Close
,
Hiroshi Sugiura
Search for other papers by Hiroshi Sugiura in
Google Scholar
PubMed Close
,
Naoto Kondo
Search for other papers by Naoto Kondo in
Google Scholar
PubMed Close
,
Shunzo Kobayashi
Search for other papers by Shunzo Kobayashi in
Google Scholar
PubMed Close
,
Yoshitaka Fujii
Search for other papers by Yoshitaka Fujii in
Google Scholar
PubMed Close
, and
Hirotaka Iwase Oncology, Breast and Endocrine Surgery, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-ku, Nagoya 467-8601, Japan

Search for other papers by Hirotaka Iwase in
Google Scholar
PubMed Close

, Ellis 2004 ). ERα is phosphorylated on multiple amino acid residues ( Lannigan 2003 ). In general, phosphorylation of serine residues in the activation function 1 (AF-1) domain of ERα appears to influence the recruitment of coactivators, resulting in

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0078
Volume/Issue:
Volume 15: Issue 3
Free access
Clarissa Wormsbaecher Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

Search for other papers by Clarissa Wormsbaecher in
Google Scholar
PubMed Close
,
Brittney M Cumbia The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

Search for other papers by Brittney M Cumbia in
Google Scholar
PubMed Close
,
Emma G Amurgis The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

Search for other papers by Emma G Amurgis in
Google Scholar
PubMed Close
,
Jillian M Poska Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

Search for other papers by Jillian M Poska in
Google Scholar
PubMed Close
,
Madeline R Price Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

Search for other papers by Madeline R Price in
Google Scholar
PubMed Close
,
Xiaokui M Mo Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA

Search for other papers by Xiaokui M Mo in
Google Scholar
PubMed Close
,
Sue E Knoblaugh Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA

Search for other papers by Sue E Knoblaugh in
Google Scholar
PubMed Close
,
Takeshi Kurita The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA

Search for other papers by Takeshi Kurita in
Google Scholar
PubMed Close
, and
Craig Joseph Burd Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

Search for other papers by Craig Joseph Burd in
Google Scholar
PubMed Close

Introduction Estrogen receptor alpha (ERα) is required for full mammary gland development. ERα-knockout mice have mammary glands that appear normal at birth but fail to mature. Specifically, adult ERα-knockout mice have a primitive ductal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0062
Volume/Issue:
Volume 30: Issue 12
Restricted access
Barbara Kuske
Search for other papers by Barbara Kuske in
Google Scholar
PubMed Close
,
Catherine Naughton
Search for other papers by Catherine Naughton in
Google Scholar
PubMed Close
,
Kate Moore
Search for other papers by Kate Moore in
Google Scholar
PubMed Close
,
Kenneth G MacLeod
Search for other papers by Kenneth G MacLeod in
Google Scholar
PubMed Close
,
William R Miller
Search for other papers by William R Miller in
Google Scholar
PubMed Close
,
Robert Clarke
Search for other papers by Robert Clarke in
Google Scholar
PubMed Close
,
Simon P Langdon
Search for other papers by Simon P Langdon in
Google Scholar
PubMed Close
, and
David A Cameron
Search for other papers by David A Cameron in
Google Scholar
PubMed Close

Introduction Estrogen receptor α (ERα) is a major growth regulator for many breast cancers and has provided an exploitable target for therapy ( Ali & Coombes 2002 ). Estrogen binding to ERα promotes conformational changes in the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01257
Volume/Issue:
Volume 13: Issue 4
Free access
Yuanzhong Wang Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California, USA

Search for other papers by Yuanzhong Wang in
Google Scholar
PubMed Close
,
Yen-Dun Tony Tzeng Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California, USA
Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, Republic of China

Search for other papers by Yen-Dun Tony Tzeng in
Google Scholar
PubMed Close
,
Gregory Chang Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California, USA

Search for other papers by Gregory Chang in
Google Scholar
PubMed Close
,
Xiaoqiang Wang Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California, USA

Search for other papers by Xiaoqiang Wang in
Google Scholar
PubMed Close
, and
Shiuan Chen Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California, USA

Search for other papers by Shiuan Chen in
Google Scholar
PubMed Close

the two most common endocrine treatments of ER+ breast cancer. Tamoxifen antagonizes the binding of estrogen to ERα, while AIs block estrogen biosynthesis by inhibition of aromatase, the key enzyme that converts androgens into estrogens. Clinical

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0258
Volume/Issue:
Volume 27: Issue 12
Restricted access
N Sarwar
Search for other papers by N Sarwar in
Google Scholar
PubMed Close
,
J-S Kim
Search for other papers by J-S Kim in
Google Scholar
PubMed Close
,
J Jiang
Search for other papers by J Jiang in
Google Scholar
PubMed Close
,
D Peston
Search for other papers by D Peston in
Google Scholar
PubMed Close
,
H D Sinnett
Search for other papers by H D Sinnett in
Google Scholar
PubMed Close
,
P Madden
Search for other papers by P Madden in
Google Scholar
PubMed Close
,
J M Gee
Search for other papers by J M Gee in
Google Scholar
PubMed Close
,
R I Nicholson
Search for other papers by R I Nicholson in
Google Scholar
PubMed Close
,
A E Lykkesfeldt
Search for other papers by A E Lykkesfeldt in
Google Scholar
PubMed Close
,
S Shousha
Search for other papers by S Shousha in
Google Scholar
PubMed Close
,
R C Coombes
Search for other papers by R C Coombes in
Google Scholar
PubMed Close
, and
S Ali
Search for other papers by S Ali in
Google Scholar
PubMed Close

Introduction It is now clear that oestrogens play a central role in promoting breast cancer development and progression ( Ali & Coombes 2002 ). In this respect, oestrogen action is mediated through the oestrogen receptors ERα and ERβ

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01123
Volume/Issue:
Volume 13: Issue 3
Free access
Corinne N Haines Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
The Ohio State University, Comprehensive Cancer Center, Columbus, Ohio, USA

Search for other papers by Corinne N Haines in
Google Scholar
PubMed Close
,
Kara M Braunreiter Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA

Search for other papers by Kara M Braunreiter in
Google Scholar
PubMed Close
,
Xiaokui Molly Mo Center for Biostatistics, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA

Search for other papers by Xiaokui Molly Mo in
Google Scholar
PubMed Close
, and
Craig J Burd Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
The Ohio State University, Comprehensive Cancer Center, Columbus, Ohio, USA

Search for other papers by Craig J Burd in
Google Scholar
PubMed Close

-dependent breast cancer, the activation of ERα ultimately leads to proliferation ( Dixon 2014 ). ER-positive breast cancers are treated with endocrine therapies that disrupt the activity of ERα ( Heldring et al . 2007 ). Unfortunately, patients develop resistance

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0496
Volume/Issue:
Volume 25: Issue 7
Free access
Philip Jonsson Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204-5056, USA

Search for other papers by Philip Jonsson in
Google Scholar
PubMed Close
,
Anne Katchy Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204-5056, USA

Search for other papers by Anne Katchy in
Google Scholar
PubMed Close
, and
Cecilia Williams Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204-5056, USA

Search for other papers by Cecilia Williams in
Google Scholar
PubMed Close

Introduction The role of estrogen receptor α (ERα ( ESR1 )) as a biological marker and target in breast cancer therapy is clear. ERα antagonists, such as tamoxifen, or estrogen ablation using aromatase inhibitors are efficient therapeutic approaches

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0444
Volume/Issue:
Volume 21: Issue 2
Free access
Sarah A Dabydeen Departments of Oncology, Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Research Building, Room 520A, Washington, District of Columbia 20057, USA

Search for other papers by Sarah A Dabydeen in
Google Scholar
PubMed Close
and
Priscilla A Furth Departments of Oncology, Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Research Building, Room 520A, Washington, District of Columbia 20057, USA
Departments of Oncology, Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Research Building, Room 520A, Washington, District of Columbia 20057, USA

Search for other papers by Priscilla A Furth in
Google Scholar
PubMed Close

Introduction Breast cancer is a heterogeneous disease consisting of four clinically relevant categories based on the expression patterns of estrogen receptor α (ERα; ESR1 ) and V-Erb-B2 avian erythroblastic leukemia viral oncogene homolog 2 ( HER2

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0512
Volume/Issue:
Volume 21: Issue 3
Free access