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Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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). Receptor activator of NF-κB ligand (RANKL)–RANK signaling has many crucial physiological roles in bone and other tissues ( Hanada et al . 2009 ), and aberrant RANKL–RANK signaling in cancer and bone cells affects cancer bone colonization ( Dougall 2011
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–Meier method and the difference between the stages and/or risk groups were compared by the log-rank test. Using Cox proportional hazards analysis, the relative importance of each staging system was determined by calculating the proportion of variation in
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-factor interaction terms in models already including genotype and parity/ menopausal status. In the prospective study, we tested differences in ovarian cancer incidence as a function of left truncated age between genotypes by log-rank statistics. Genotype
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NA 5 (71.4) 0 (0) 2 (28.6) 37 (64.9) 3 (5.3) 17 (29.8) 0.526 0.526 0.945 NA = not available. EFS The median EFS in groups A, B, and C and in group D was 16.5 and 16.0 months, respectively (log-rank test, P = 0
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Oncology and Hemato-Oncology Department, Università degli Studi di Milano, Milan, Italy
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threshold (HR 0.80, 95% CI: 0.63–1.02). On ranking analysis, combination of everolimus plus SSAs ( P score 0.86) and then everolimus alone ( P score 0.65) were ranked highest in increasing PFS, with the former detected as the best treatment strategy in
Department of Diabetology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Gastroenterology and Digestive Oncology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Digestive Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Digestive Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Diabetology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Pathology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Gastroenterology and Digestive Oncology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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for quantitative variables and Chi-squared test or Fisher’s test for qualitative variables. Survival curves were obtained with Kaplan–Meier estimates and compared using the log-rank test. Cox proportional hazards regression was used for the DFS
Department of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People’s Republic of China
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Department of Clinical Sciences, College of Medicine, University of South Florida, Tampa, Florida, USA
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Department of Clinical Sciences, College of Medicine, University of South Florida, Tampa, Florida, USA
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cell lines for each of the four drugs. Several different statistical methods have been used for this analysis, including Pearson product–moment correlation, Spearman’s rank-order correlation, Welch’s two-sample t -test by grouping the cell line into
Tel Aviv University Faculty of Medicine, Tel Aviv, Israel
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Tel Aviv University Faculty of Medicine, Tel Aviv, Israel
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Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
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Personalized Preventive Genetics Center, Assuta Medical Center, Tel-Aviv, Israel
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The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Hashomer, Israel
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Tel Aviv University Faculty of Medicine, Tel Aviv, Israel
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analysis Time-dependent risk analyses were based on the Kaplan–Meier model, plots were generated using survminer package ( https://cran.r-project.org/package=survminer ), and for statistical analysis of time-dependent events, we used the log-rank test
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.15 (from the log-rank test comparing two arms) would indicate the study regimen promising for further evaluation ( Mandrekar & Sargent 2010 ). Study accrual was extended to 150 patients due to concerns about achieving an adequate number of progression
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receptor RANK, thereby inhibiting osteoclastogenesis ( Anderson et al. 1997 ). In vitro studies have demonstrated the synthesis of OPG by stromal cell line and osteoblasts and its stimulation by oestrogen ( Hofbauer et al. 1999 , Saika et al. 2001