-operation, radiation therapy, pharmacological treatment and bilateral adrenalectomy (BADX). In contrast with the other options, BADX almost invariably leads to permanent correction of cortisol excess and, although it is associated with lifelong primary adrenal
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Elena Valassi, Frédéric Castinetti, Amandine Ferriere, Stylianos Tsagarakis, Richard A Feelders, Romana T Netea-Maier, Michael Droste, Christian J Strasburger, Dominique Maiter, Darko Kastelan, Philippe Chanson, Susan M Webb, Frank Demtröder, Valdis Pirags, Olivier Chabre, Holger Franz, Alicia Santos, and Martin Reincke
Carole Guerin, David Taieb, Giorgio Treglia, Thierry Brue, André Lacroix, Frederic Sebag, and Frederic Castinetti
, Louiset et al . 2013 ), or primary pigmented nodular adrenal disease (PPNAD) that is frequently due to mutations of PRKAR1A ( Bertherat 2006 ). All of these conditions apart from the unilateral adrenal tumours can benefit from bilateral adrenalectomy
Dimitra A Vassiliadi and Stylianos Tsagarakis
Bilateral adrenalectomy Bilateral adrenalectomy is generally considered the treatment of choice for patients with overt CS due to PBMAH. This choice, when made, needs to be based on good clinical grounds supporting that the benefits outweigh the adverse
Perrine Raymond, Gérald Raverot, and Mirela-Diana Ilie
cavernous sinus, proliferation markers, treatments (surgery, radiotherapy, chemotherapy and other systemic medical treatments, and bilateral adrenalectomy), and survival after the initial diagnosis; and for the metastases/PC the time between the initial
Samuel M O’Toole, Anju Sahdev, Satya Bhattacharya, Roger Feakins, Evelien F Gevers, and William M Drake
programme. She developed bilateral phaeochromocytomas and underwent staged bilateral adrenalectomies at the age of 12 and 14 respectively. At the age of 16, she was discovered to have a 2.5 cm tail of pancreas pNET on routine surveillance imaging ( Fig. 1E
R van der Pas, W W de Herder, L J Hofland, and R A Feelders
severe co-morbidity). These therapeutic options include radiotherapy, bilateral adrenalectomy, and medical therapy. Each of these options has its limitations due to variable response rates and complications, and in each individual patient, the pros and
Jessica L Geiger, Simion I Chiosea, Sue M Challinor, Marina N Nikiforova, and Julie E Bauman
hernia repair. The patient underwent bilateral adrenalectomies with pathology confirming pheochromocytoma. Germline genetic testing revealed the codon M918T point mutation in the RET proto-oncogene, consistent with a diagnosis of MEN2B. The patient
Frederic Castinetti, Ana Luiza Maia, Mariola Peczkowska, Marta Barontini, Kornelia Hasse-Lazar, Thera P Links, Rodrigo A Toledo, Sarka Dvorakova, Caterina Mian, Maria Joao Bugalho, Stefania Zovato, Maria Alevizaki, Andrei Kvachenyuk, Birke Bausch, Paola Loli, Simona R Bergmann, Attila Patocs, Marija Pfeifer, Josefina Biarnes Costa, Ernst von Dobschuetz, Claudio Letizia, Gerlof Valk, Marcin Barczynski, Malgorzata Czetwertynska, John T M Plukker, Paola Sartorato, Tomas Zelinka, Petr Vlcek, Svetlana Yaremchuk, Georges Weryha, Letizia Canu, Nelson Wohllk, Frederic Sebag, Martin K Walz, Charis Eng, and Hartmut P H Neumann
management viewpoint, a delay of more than 15 years was observed between the age at which patients would present bilateral PHEO (and thus a definite adrenal insufficiency when treated by bilateral adrenalectomy) in Europe vs South America. This could be due
Lucia Gagliardi, King-Hwa Ling, Chung H Kok, Joseph Carolan, Peter Brautigan, Rosalie Kenyon, Richard J D'Andrea, Mark Van der Hoek, Christopher N Hahn, David J Torpy, and Hamish S Scott
florid CS ( Gagliardi et al . 2009 ). Bilateral adrenalectomy (combined weight 130 g) was curative, but he died from recurrent sepsis. His siblings, aged 61 and 65 years, presented with early CS; whilst lacking a Cushingoid phenotype, they had
Alastair H Davies and Amina Zoubeidi
Bilateral adrenalectomy in prostatic cancer: clinical features and urinary excretion of 17-ketosteroids and estrogen . Annals of Surgery 122 1031 – 10 41 . ( https://doi.org/10.1097/00000658-194512260-00012 ) Huggins C Stephens RC Hodges CV
