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Maria Riedmeier
Maria Riedmeier
University Children’s Hospital, Department of Pediatric Hematology, Oncology and Stem cell transplantation, University of Wuerzburg, Wuerzburg, Germany.
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Lester D R Thompson
Lester D R Thompson
Head and Neck Pathology Consultations, Los Angeles, California, USA
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Carlos Augusto Fernandes Molina
Carlos Augusto Fernandes Molina
Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Boris Decarolis
Boris Decarolis
Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany
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Christoph Härtel
Christoph Härtel
University Children’s Hospital, Department of Pediatric Hematology, Oncology and Stem cell transplantation, University of Wuerzburg, Wuerzburg, Germany.
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Paul-G Schlegel
Paul-G Schlegel
University Children’s Hospital, Department of Pediatric Hematology, Oncology and Stem cell transplantation, University of Wuerzburg, Wuerzburg, Germany.
Comprehensive Cancer Centre Mainfranken, University of Wuerzburg Medical Centre, Wuerzburg, Germany
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Comprehensive Cancer Centre Mainfranken, University of Wuerzburg Medical Centre, Wuerzburg, Germany
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Martin Fassnacht
Martin Fassnacht
Comprehensive Cancer Centre Mainfranken, University of Wuerzburg Medical Centre, Wuerzburg, Germany
Department of Medicine, Division of Endocrinology and Diabetes, University Hospital, University of Wuerzburg, Wuerzburg, Germany
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Department of Medicine, Division of Endocrinology and Diabetes, University Hospital, University of Wuerzburg, Wuerzburg, Germany
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Verena Wiegering
Verena Wiegering
University Children’s Hospital, Department of Pediatric Hematology, Oncology and Stem cell transplantation, University of Wuerzburg, Wuerzburg, Germany.
Comprehensive Cancer Centre Mainfranken, University of Wuerzburg Medical Centre, Wuerzburg, Germany
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Comprehensive Cancer Centre Mainfranken, University of Wuerzburg Medical Centre, Wuerzburg, Germany
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remains difficult, and clinical prediction and stratification scores are not evaluated yet in pediatric settings. The Weiss histopathologic scoring system, intended and well established for the classification of adrenocortical neoplasms in adults
D Cecchin
D Cecchin
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F Lumachi
F Lumachi
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M C Marzola
M C Marzola
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G Opocher
G Opocher
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C Scaroni
C Scaroni
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P Zucchetta
P Zucchetta
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F Mantero
F Mantero
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F Bui
F Bui
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apparently positive 123 I-MIBG scan ( Maurea et al. 1995 ), has not, to our knowledge, been fully clarified in the literature. The aim of this study was to assess the usefulness of a scoring system, based on different uptakes of the
Carla Colombo
Carla Colombo
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Marina Muzza
Marina Muzza
Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Gabriele Pogliaghi
Gabriele Pogliaghi
Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Sonia Palazzo
Sonia Palazzo
Pathology Unit, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Guia Vannucchi
Guia Vannucchi
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Leonardo Vicentini
Leonardo Vicentini
Endocrine Surgery Unit, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Luca Persani
Luca Persani
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Giacomo Gazzano
Giacomo Gazzano
Pathology Unit, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Laura Fugazzola
Laura Fugazzola
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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found in TC ( Pesenti et al. 2018 , Colombo et al. 2019 ). To further increase the sensitivity and specificity of this molecular tool, we set up an unprecedented ‘thyroid risk score’ system (TRS) based on the combination of clinical, ultrasound
Yu-Li Chen
Yu-Li Chen
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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Cheng-Yang Chou
Cheng-Yang Chou
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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Ming-Cheng Chang
Ming-Cheng Chang
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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Han-Wei Lin
Han-Wei Lin
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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Ching-Ting Huang
Ching-Ting Huang
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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Shu-Feng Hsieh
Shu-Feng Hsieh
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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Chi-An Chen
Chi-An Chen
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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Wen-Fang Cheng
Wen-Fang Cheng
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
College of Medicine, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, Graduate Institute of Anatomy and Cell Biology, National Taiwan University, No. 1, Section 1, Jen‐Ai Road, Taipei, Taiwan
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used as the derivation group to select target clinical and immunological factors to generate a risk-scoring system to predict patient survival. Eighty-two cases from another hospital were used as the validation group to evaluate this risk-scoring system
Dong Hyun Seo
Dong Hyun Seo
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
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Seul Gi Lee
Seul Gi Lee
Yonsei University Graduate School of Medical Science, Seoul, South Korea
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Soon Min Choi
Soon Min Choi
Department of Surgery, Hallym Hospital, Incheon, South Korea
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Ha Yan Kim
Ha Yan Kim
Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, South Korea
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Sunmi Park
Sunmi Park
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
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Sang Geun Jung
Sang Geun Jung
Department of Gynecological Oncology, Bundang CHA Medical Center, CHA University Gyeonggi-do, South Korea
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Young Suk Jo
Young Suk Jo
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
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Jandee Lee
Jandee Lee
Department of Surgery, Open NBI Convergence Technology Research Laboratory, Yonsei University College of Medicine, Seoul, South Korea
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was performed, and data labeling for each scoring system was indicated as follows: (1) differentiation score (DF), TERT (−) PTC was labeled as a positive input against the others; (2) immune resistance score (IR), TERT (+) PTC was labeled as a
Benjamin Easton White
Benjamin Easton White
Department of Gastroenterology, Hampshire Hospitals NHS Foundation Trust, Basingstoke, Hampshire, UK
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Maralyn R Druce
Maralyn R Druce
Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, London, UK
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Simona Grozinsky-Glasberg
Simona Grozinsky-Glasberg
Neuroendocrine Tumor Unit, ENETS Center of Excellence, Department of Endocrinology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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Rajaventhan Srirajaskanthan
Rajaventhan Srirajaskanthan
King’s Health Partners ENETS Centre of Excellence, Kings College hospital, London, UK
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Eva Maria Gamper
Eva Maria Gamper
Eva Maria Gamper – Innsbruck Institute of Patient-centered Outcome Research (IIPCOR), Innsbruck, Austria
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Debra Gray
Debra Gray
Department of Psychology, University of Winchester, Hampshire, UK
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Ruben Mujica-Mota
Ruben Mujica-Mota
Academic Unit of Health Economics, Institute of Health Sciences, University of Leeds, Leeds, UK
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John K Ramage
John K Ramage
Department of Gastroenterology, Hampshire Hospitals NHS Foundation Trust, Basingstoke, Hampshire, UK
King’s Health Partners ENETS Centre of Excellence, Kings College hospital, London, UK
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King’s Health Partners ENETS Centre of Excellence, Kings College hospital, London, UK
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development. Clinical validation is ongoing, including in NEN patients (personal communication with project PI). The use of HRQoL scores in published data HRQoL measured in NEN clinical trials Use of QoL scoring systems in NEN trials was reviewed
Marie McIlroy
Marie McIlroy
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Fergal J Fleming
Fergal J Fleming
Department of Surgery, Department of Surgery, Drug Safety Research Unit, Royal College of Surgeons in Ireland, Dublin 2, Ireland
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Yvonne Buggy
Yvonne Buggy
Department of Surgery, Department of Surgery, Drug Safety Research Unit, Royal College of Surgeons in Ireland, Dublin 2, Ireland
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Arnold D K Hill
Arnold D K Hill
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Leonie S Young
Leonie S Young
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assessed using a modified Allred scoring system. SRC3 expression was significantly elevated in metastatic tumours following endocrine treatment in HER2 positive patients ( P =0.038, n =3 patients/group, Students t test), but not in HER2 negative patients
Sara Pusceddu
Sara Pusceddu
Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
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Francesco Barretta
Francesco Barretta
Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Milan, Italy
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Annalisa Trama
Annalisa Trama
Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Evaluative Epidemiology Unit, ENETS Center of Excellence, Milan, Italy
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Laura Botta
Laura Botta
Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Evaluative Epidemiology Unit, ENETS Center of Excellence, Milan, Italy
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Massimo Milione
Massimo Milione
Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, ENETS Center of Excellence, Milan, Italy
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Roberto Buzzoni
Roberto Buzzoni
Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
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Filippo De Braud
Filippo De Braud
Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
University of Milan, Milan, Italy
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University of Milan, Milan, Italy
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Vincenzo Mazzaferro
Vincenzo Mazzaferro
University of Milan, Milan, Italy
Liver Surgery, Transplantation and Gastroenterology, University of Milan and Istituto Nazionale Tumori Fondazione IRCCS, ENETS Center of Excellence, Milano, Milan, Italy
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Liver Surgery, Transplantation and Gastroenterology, University of Milan and Istituto Nazionale Tumori Fondazione IRCCS, ENETS Center of Excellence, Milano, Milan, Italy
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Ugo Pastorino
Ugo Pastorino
Department of Thoracic Surgical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, ENETS Center of Excellence, Milan, Italy
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Ettore Seregni
Ettore Seregni
Department of Nuclear Medicine ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Milan, Italy
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Luigi Mariani
Luigi Mariani
Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Milan, Italy
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Gemma Gatta
Gemma Gatta
Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Evaluative Epidemiology Unit, ENETS Center of Excellence, Milan, Italy
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Maria Di Bartolomeo
Maria Di Bartolomeo
Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
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Daniela Femia
Daniela Femia
Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
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Natalie Prinzi
Natalie Prinzi
Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
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Jorgelina Coppa
Jorgelina Coppa
Liver Surgery, Transplantation and Gastroenterology, University of Milan and Istituto Nazionale Tumori Fondazione IRCCS, ENETS Center of Excellence, Milano, Milan, Italy
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Francesco Panzuto
Francesco Panzuto
Department of Medical Gastroenterology, Azienda Ospedaliera Sant’Andrea, Roma ENETS Center of Excellence, Rome, Italy
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Lorenzo Antonuzzo
Lorenzo Antonuzzo
Department of Medical Oncology, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy
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Emilio Bajetta
Emilio Bajetta
Department of Medical Oncology, Policlinico di Monza, Monza, Italy
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Maria Pia Brizzi
Maria Pia Brizzi
Department of Medical Oncology, Azienda Ospedaliera Universitaria San Luigi Gonzaga, Orbassano, Italy
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Davide Campana
Davide Campana
Department of Medical Oncology, Policlinico Sant’Orsola Malpighi, Bologna, Italy
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Laura Catena
Laura Catena
Department of Medical Oncology, Policlinico di Monza, Monza, Italy
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Harry Comber
Harry Comber
Ireland National Cancer Registry, Cork, Ireland
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Fiona Dwane
Fiona Dwane
Ireland National Cancer Registry, Cork, Ireland
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Nicola Fazio
Nicola Fazio
Department of Medical Oncology, IEO – Istituto Europeo di Oncologia, Milano, ENETS Center of Excellence, Milan, Italy
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Antongiulio Faggiano
Antongiulio Faggiano
Department of Thyroid and Parathyroid Surgery Unit, Azienda Ospedaliera Universitaria Federico II, ENETS Center of Excellence, Naples, Italy
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Dario Giuffrida
Dario Giuffrida
Department of Medical Oncology, IOM – Istituto Oncologico del Mediterraneo, Catania, Italy
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Kris Henau
Kris Henau
Belgian Cancer Registry, Brussels, Belgium
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Toni Ibrahim
Toni Ibrahim
Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, IRCCS, Meldola, Italy
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Riccardo Marconcini
Riccardo Marconcini
Department of Medical Oncology, Ospedale Santa Chiara, Pisa, Italy
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Sara Massironi
Sara Massironi
Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy
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Maja Primic Žakelj
Maja Primic Žakelj
Institute of Oncology Ljubljana, Epidemiology and Cancer Registry, Ljubljana, Slovenia
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Francesca Spada
Francesca Spada
Department of Medical Oncology, IEO – Istituto Europeo di Oncologia, Milano, ENETS Center of Excellence, Milan, Italy
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Salvatore Tafuto
Salvatore Tafuto
Department of Medical Oncology, Fondazione IRCCS Pascale, ENETS Center of Excellence, Naples, Italy
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Elizabeth Van Eycken
Elizabeth Van Eycken
Belgian Cancer Registry, Brussels, Belgium
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Jan Maaten Van der Zwan
Jan Maaten Van der Zwan
Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands
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Tina Žagar
Tina Žagar
Institute of Oncology Ljubljana, Epidemiology and Cancer Registry, Ljubljana, Slovenia
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Luca Giacomelli
Luca Giacomelli
Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy
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Rosalba Miceli
Rosalba Miceli
Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Milan, Italy
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NEPscore Working Group
NEPscore Working Group
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derived a covariate scoring system based on the 10-year OS predicted by the final Cox model. Then, a three-level prognostic score was derived for classifying patients according to their predicted 10-year OS: (i) favorable risk group: OS ≥70%; (ii
Brian Hung-Hin Lang
Brian Hung-Hin Lang
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Chung-Yau Lo
Chung-Yau Lo
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Wai-Fan Chan
Wai-Fan Chan
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King-Yin Lam
King-Yin Lam
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Koon-Yat Wan
Koon-Yat Wan
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date of diagnosis: 1957–1972 and 1973–1988. A Cox model analysis using a stepwise variable selection led to a prognostic model derived from the former cohort. The prognostic scoring system was validated with the latter cohort. Under this system, a
Arja Jukkola
Arja Jukkola
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Risto Bloigu
Risto Bloigu
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Tapani Ebeling
Tapani Ebeling
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Pasi Salmela
Pasi Salmela
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Guillermo Blanco
Guillermo Blanco
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mortality rate for each at 20 years of follow-up. When our population was assessed according to these variables and the scoring system used to create the MACIS staging classification, four risk groups emerged: a low-risk group (score 0–6.9) with a survival
