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Halfdan Sorbye Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Sciences, University of Bergen, Bergen, Norway

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Grace Kong Department of Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Unit, ENETS Center of Excellence, Department of Endocrinology and Metabolism, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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, there is relatively high consistency in the effectiveness of PRRT for gastroenteropancreatic (GEP) NET, with an encouraging 40% response rate (RR), 80% disease control rate (DCR) and long overall survival (OS) ( Brabander et al . 2017 , Hicks et al

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0400
Volume/Issue:
Volume 27: Issue 3
Free access
Andreas Venizelos K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

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Hege Elvebakken Department of Oncology, Ålesund Hospital, Møre og Romsdal Hospital Trust, Ålesund, Norway
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway

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Aurel Perren Institute of Pathology, University of Bern, Bern, Switzerland

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Oleksii Nikolaienko K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

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Wei Deng K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

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Inger Marie B Lothe Department of Pathology, Oslo University Hospital, Oslo, Norway

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Anne Couvelard Department of Pathology, Université de Paris, Bichat Hospital, AP-HP, Paris, France

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Geir Olav Hjortland Department of Oncology, Oslo University Hospital, Oslo, Norway

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Anna Sundlöv Departmentt of Oncology, Skåne University Hospital, Lund, Sweden
Department of Medical Radiation Physics, Lund University, Lund, Sweden

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Johanna Svensson Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden

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Harrish Garresori Department of Oncology, Stavanger University Hospital, Stavanger, Norway

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Christian Kersten Department of Research, Hospital of Southern Norway, Kristiansand, Norway

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Eva Hofsli Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
Department of Oncology, St.Olavs Hospital, Trondheim, Norway

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Sönke Detlefsen Department of Pathology, Odense University Hospital, Odense, Denmark
Department of Clinical Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

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Merete Krogh Department of Oncology, Odense University Hospital, Odense, Denmark

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Halfdan Sorbye Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway

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Stian Knappskog K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

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Introduction High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are defined by the presence of neuroendocrine phenotype and a high proliferation rate (Ki-67 > 20%). The HG NEN entity consists of well

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-21-0152
Volume/Issue:
Volume 29: Issue 1
Open access
Andrew McDonald Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Vaidehi Avadhani Grady Memorial Hospital, Atlanta, Georgia, USA

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Gabriela Oprea-Ilies Grady Memorial Hospital, Atlanta, Georgia, USA

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Katerina Zakka Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Gregory B Lesinski Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Olumide B Gbolahan Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Olatunji Alese Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Introduction Neuroendocrine neoplasms (NENs) of the gastroenteropancreatic (GEP) system are a heterogeneous group of rare malignancies. While the incidence of NENs was relatively low, with 6.98 cases per 100,000 adults in 2012, the incidence

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-24-0046
Volume/Issue:
Volume 31: Issue 10
Restricted access
Florian Bösch Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany

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Katharina Brüwer Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany

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Annelore Altendorf-Hofmann Department of General, Visceral und Vascular Surgery, Friedrich-Schiller University, Jena, Germany

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Christoph J Auernhammer Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, Ludwig-Maximilians-University Munich, Munich, Germany

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Christine Spitzweg Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, Ludwig-Maximilians-University Munich, Munich, Germany

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C Benedikt Westphalen Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Medicine 3 and Comprehensive Cancer Center, Ludwig-Maximilians-University Munich, Munich, Germany

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Stefan Boeck Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Medicine 3 and Comprehensive Cancer Center, Ludwig-Maximilians-University Munich, Munich, Germany

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Gabriele Schubert-Fritschle Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Munich Cancer Registry (MCR) of the Munich Tumour Centre (TZM), Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Ludwig-Maximilians-University Munich, Munich, Germany

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Jens Werner Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany

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Volker Heinemann Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Medicine 3 and Comprehensive Cancer Center, Ludwig-Maximilians-University Munich, Munich, Germany

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Thomas Kirchner Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany

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Martin Angele Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany

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Thomas Knösel Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany

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, Lawrence et al . 2011 ). Thus, NENs are nowadays as frequent as testicular tumors, Hodgkin’s disease, gliomas and multiple myeloma ( Modlin et al . 2008 ). Gastroenteropancreatic NENs (GEP-NENs) represent the preponderance with primaries localized in the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0494
Volume/Issue:
Volume 26: Issue 3
Free access
Taymeyah Al-Toubah Department of GI Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Stefano Partelli Pancreas Translational & Clinical Research Center, Ospedale San Raffaele IRCCS, Milano, Italy
Università, Vita e Salute, Milan, Italy

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Mauro Cives Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy

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Valentina Andreasi Pancreas Translational & Clinical Research Center, Ospedale San Raffaele IRCCS, Milano, Italy

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Franco Silvestris Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy

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Massimo Falconi Pancreas Translational & Clinical Research Center, Ospedale San Raffaele IRCCS, Milano, Italy
Università, Vita e Salute, Milan, Italy

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Daniel A Anaya Department of GI Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Jonathan Strosberg Department of GI Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Introduction Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors which include NETs of the gastrointestinal tract and pancreas. Tumor grade and differentiation are important prognostic factors. Low

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0462
Volume/Issue:
Volume 26: Issue 4
Free access
Günter Klöppel Department of Pathology, Technical University of München, Ismaninger Strasse 22, 81675 München, Germany

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, but is not specific for these tumours ( Klöppel et al . 2009 ). Under the electron microscope the NENs show typical neurosecretory granules. This review deals with the classification of the gastroenteropancreatic NENs (GEP-NENs) and discusses briefly

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0013
Volume/Issue:
Volume 18: Issue S1
Free access
Nicole Panarelli Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

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Kathrin Tyryshkin Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Justin Jong Mun Wong Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Adrianna Majewski Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Xiaojing Yang Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Theresa Scognamiglio Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

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Michelle Kang Kim Center for Carcinoid and Neuroendocrine Tumors of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Kimberly Bogardus HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

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Thomas Tuschl HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

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Yao-Tseng Chen Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

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Neil Renwick Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada
HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

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Introduction Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are increasingly common and clinically diverse neoplasms ( Yao et al . 2008 , Lawrence et al . 2011 ) that are challenging to evaluate histologically ( Klimstra 2016

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0244
Volume/Issue:
Volume 26: Issue 1
Free access
Bristi Basu Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

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Bhawna Sirohi Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

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Pippa Corrie Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

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Factors predicting tracer uptake in somatostatin receptor and MIBG scintigraphy of metastatic gastroenteropancreatic neuroendocrine tumours . Journal of Nuclear Medicine 47 223 – 233 . Faiss S Scherubl H Riecken EO

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0108
Volume/Issue:
Volume 17: Issue 1
Free access
Atsuko Kasajima Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany
Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Marianne Pavel Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Silvia Darb-Esfahani Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Aurelia Noske Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Albrecht Stenzinger Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany
Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Hironobu Sasano Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Manfred Dietel Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Carsten Denkert Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Christoph Röcken Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Bertram Wiedenmann Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Wilko Weichert Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany
Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany

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Introduction With an incidence rate of about 2.5–5 cases per 100 000 person-years, gastroenteropancreatic neuroendocrine tumours (GEP-NET) are rather rare neoplasms when compared with adenocarcinomas of the same locations ( Modlin et al . 2008

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0126
Volume/Issue:
Volume 18: Issue 1
Free access
Georgios K Dimitriadis The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
Division of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, UK
Division of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Campus, London, UK

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Martin O Weickert The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
Division of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, UK
Centre for Applied Biological and Exercise Sciences, Coventry University, Coventry, UK

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Harpal S Randeva The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
Division of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, UK
Centre for Applied Biological and Exercise Sciences, Coventry University, Coventry, UK

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Gregory Kaltsas The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
Division of Pathophysiology, National and Kapodistrian University of Athens Medical School, Athens, Greece
Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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Ashley Grossman Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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Introduction Gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) are considered to be relatively rare, with an estimated incidence of 3–5 cases per 100,000 inhabitants; however, recent data indicate that their prevalence is increasing

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0200
Volume/Issue:
Volume 23: Issue 9
Free access