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Jennifer R Eads
Jennifer R Eads
Division of Hematology and Oncology, Abramson Cancer Center, University of Pennsylvania, Pennsylvania, USA
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Thorvardur R Halfdanarson
Thorvardur R Halfdanarson
Division of Medical Oncology, Mayo Clinic Cancer Center, Rochester, Minnesota, USA
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Tim Asmis
Tim Asmis
Division of Medical Oncology, University of Ottawa, Ottawa, Ontario, Canada
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Andrew M Bellizzi
Andrew M Bellizzi
Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
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Emily K Bergsland
Emily K Bergsland
Department of Medicine, University of California, San Francisco, California, USA
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Arvind Dasari
Arvind Dasari
Division of Gastrointestinal Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Ghassan El-Haddad
Ghassan El-Haddad
Department of Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
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Michael Frumovitz
Michael Frumovitz
Division of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Joshua Meyer
Joshua Meyer
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
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Erik Mittra
Erik Mittra
Division of Molecular Imaging and Therapy, Oregon Health & Science University, Portland, Oregon, USA
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Sten Myrehaug
Sten Myrehaug
Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
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Eric Nakakura
Eric Nakakura
Department of Surgery, University of California, San Francisco, California, USA
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Nitya Raj
Nitya Raj
Department of Medicine, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
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Heloisa P Soares
Heloisa P Soares
Division of Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Salt Lake City, Utah, USA
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Brian Untch
Brian Untch
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
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Namrata Vijayvergia
Namrata Vijayvergia
Department of Hematology and Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
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Jennifer A Chan
Jennifer A Chan
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
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Introduction High-grade neuroendocrine neoplasms (NENs) constitute a rare disease entity and account for approximately 10% of all NENs. Given their rarity, there is a paucity of prospective data to guide the optimal diagnosis and management of
Andreas Venizelos
Andreas Venizelos
K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Hege Elvebakken
Hege Elvebakken
Department of Oncology, Ålesund Hospital, Møre og Romsdal Hospital Trust, Ålesund, Norway
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
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Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
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Aurel Perren
Aurel Perren
Institute of Pathology, University of Bern, Bern, Switzerland
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Oleksii Nikolaienko
Oleksii Nikolaienko
K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Wei Deng
Wei Deng
K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Inger Marie B Lothe
Inger Marie B Lothe
Department of Pathology, Oslo University Hospital, Oslo, Norway
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Anne Couvelard
Anne Couvelard
Department of Pathology, Université de Paris, Bichat Hospital, AP-HP, Paris, France
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Geir Olav Hjortland
Geir Olav Hjortland
Department of Oncology, Oslo University Hospital, Oslo, Norway
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Anna Sundlöv
Anna Sundlöv
Departmentt of Oncology, Skåne University Hospital, Lund, Sweden
Department of Medical Radiation Physics, Lund University, Lund, Sweden
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Department of Medical Radiation Physics, Lund University, Lund, Sweden
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Johanna Svensson
Johanna Svensson
Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Harrish Garresori
Harrish Garresori
Department of Oncology, Stavanger University Hospital, Stavanger, Norway
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Christian Kersten
Christian Kersten
Department of Research, Hospital of Southern Norway, Kristiansand, Norway
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Eva Hofsli
Eva Hofsli
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
Department of Oncology, St.Olavs Hospital, Trondheim, Norway
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Department of Oncology, St.Olavs Hospital, Trondheim, Norway
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Sönke Detlefsen
Sönke Detlefsen
Department of Pathology, Odense University Hospital, Odense, Denmark
Department of Clinical Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Department of Clinical Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Merete Krogh
Merete Krogh
Department of Oncology, Odense University Hospital, Odense, Denmark
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Halfdan Sorbye
Halfdan Sorbye
Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway
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Department of Clinical Science, University of Bergen, Bergen, Norway
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Stian Knappskog
Stian Knappskog
K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Introduction High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are defined by the presence of neuroendocrine phenotype and a high proliferation rate (Ki-67 > 20%). The HG NEN entity consists of well
Halfdan Sorbye
Halfdan Sorbye
Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Sciences, University of Bergen, Bergen, Norway
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Department of Clinical Sciences, University of Bergen, Bergen, Norway
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Grace Kong
Grace Kong
Department of Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia
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Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia
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Simona Grozinsky-Glasberg
Simona Grozinsky-Glasberg
Neuroendocrine Tumor Unit, ENETS Center of Excellence, Department of Endocrinology and Metabolism, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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-term toxicity. 177 Lu-DOTA-octreotate (LuTathera) has recently obtained regulatory approval for patients with progressive metastatic grade 1–2 GEP NET. High-grade gastroenteropancreatic neuroendocrine neoplasms: NET G3 and NEC Gastroenteropancreatic
A Mohamed
A Mohamed
Division of Hematology and Medical Oncology, UH Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
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M Trybula
M Trybula
Division of Hematology and Medical Oncology, UH Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
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S L Asa
S L Asa
Department of Medicine, UH Seidman Cancer Center Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
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T R Halfdanarson
T R Halfdanarson
Division of Medical Oncology, Department of Oncology, Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota, USA
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M B Sonbol
M B Sonbol
Division of Hematology and Medical Oncology, Mayo Clinic Cancer Center, Phoenix, Arizona, USA
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al. 2022 ). This classification was broadened to include all NENs regardless of the primary tumor origin in the 2022 WHO classification (2022). G3 GEP-NETs, characterized by both well-differentiated and high-grade features (Ki-67 > 20%), exhibit a
Esben Andreas Carlsen
Esben Andreas Carlsen
Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen, Denmark
Department of Biomedical Sciences, Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark
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Department of Biomedical Sciences, Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark
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Nicola Fazio
Nicola Fazio
Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy
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Dan Granberg
Dan Granberg
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Simona Grozinsky-Glasberg
Simona Grozinsky-Glasberg
Neuroendocrine Tumor Unit, Department of Endocrinology & Metabolism, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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Hojjat Ahmadzadehfar
Hojjat Ahmadzadehfar
Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany
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Chiara Maria Grana
Chiara Maria Grana
Division of Nuclear Medicine, IEO, European Institute of Oncology IRCCS, Milan, Italy
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Wouter T Zandee
Wouter T Zandee
Erasmus Medical Center, Rotterdam, The Netherlands
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Jaroslaw Cwikla
Jaroslaw Cwikla
Medical School, University of Warmia and Mazury, Olsztyn, Poland
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Martin A Walter
Martin A Walter
Department of Nuclear Medicine, University Hospital of Geneva, Geneva, Switzerland
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Peter Sandor Oturai
Peter Sandor Oturai
Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen, Denmark
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Anja Rinke
Anja Rinke
Department of Gastroenterology, University Hospital Gießen and Marburg, Marburg, Germany
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Andrew Weaver
Andrew Weaver
Department of Oncology, Churchill Hospital, Oxford, UK
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Andrea Frilling
Andrea Frilling
Department of Surgery and Cancer, Imperial College London, London, UK
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Sara Gritti
Sara Gritti
Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy
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Anne Kirstine Arveschoug
Anne Kirstine Arveschoug
Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark
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Amichay Meirovitz
Amichay Meirovitz
Department of Oncology and Radiation Therapy Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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Ulrich Knigge
Ulrich Knigge
Department of Biomedical Sciences, Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark
Departments of Surgical Gastroenterology and Clinical Endocrinology, Rigshospitalet, Copenhagen, Denmark
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Departments of Surgical Gastroenterology and Clinical Endocrinology, Rigshospitalet, Copenhagen, Denmark
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Halfdan Sorbye
Halfdan Sorbye
Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway
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Department of Clinical Science, University of Bergen, Bergen, Norway
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poorly differentiated high-grade neuroendocrine carcinomas (G3). The terminology of NEN G3 relates to all high-grade (G3, Ki-67 >20%) neuroendocrine malignancies; i.e. both NET G3 and NEC. Gastroenteropancreatic (GEP) NENs G3 are rare, highly malignant
Cecile N Chougnet
Cecile N Chougnet
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Sophie Leboulleux
Sophie Leboulleux
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Caroline Caramella
Caroline Caramella
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Jean Lumbroso
Jean Lumbroso
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Isabelle Borget
Isabelle Borget
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Désirée Déandreis
Désirée Déandreis
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Pierre Duvillard
Pierre Duvillard
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Dominique Elias
Dominique Elias
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Thierry de Baere
Thierry de Baere
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Fritz-Line Vélayoudom-Céphise
Fritz-Line Vélayoudom-Céphise
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Joël Guigay
Joël Guigay
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Michel Ducreux
Michel Ducreux
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Martin Schlumberger
Martin Schlumberger
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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Eric Baudin
Eric Baudin
Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology
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or PET status ( Garin et al . 2009 , Binderup et al . 2010 a ). More precisely, high-grade of SRS uptake was recently found to carry prognostic information ( Imhof et al . 2011 ). However, in the absence of randomized study, the respective
Thomas Yang Sun
Thomas Yang Sun
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
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Lan Zhao
Lan Zhao
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
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Paul Van Hummelen
Paul Van Hummelen
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
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Brock Martin
Brock Martin
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
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Kathleen Hornbacker
Kathleen Hornbacker
Clinical Trials Office, Stanford University, Stanford, California, USA
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HoJoon Lee
HoJoon Lee
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
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Li C Xia
Li C Xia
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Division of Biostatistics, Department of Epidemiology and Public Health, Albert Einstein College of Medicine, Bronx, New York, USA
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Division of Biostatistics, Department of Epidemiology and Public Health, Albert Einstein College of Medicine, Bronx, New York, USA
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Sukhmani K Padda
Sukhmani K Padda
Cedars-Sinai Medical Center, Department of Medical Oncology, Los Angeles, California, USA
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Hanlee P Ji
Hanlee P Ji
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Stanford Genome Technology Center, Stanford, California, USA
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Stanford Genome Technology Center, Stanford, California, USA
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Pamela Kunz
Pamela Kunz
Yale School of Medicine, Smilow Cancer Hospital, Yale Cancer Center, New Haven, Connecticut, USA
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, high-grade (grade 3, G3) NENs have an OS of only about 7 months ( Dasari et al. 2017 , 2018 ). These G3 NENs are rare, with an annual incidence of 10.52 per 100,000 worldwide ( Leoncini et al. 2017 ). They are most often poorly differentiated but
Andreas Venizelos
Andreas Venizelos
K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Halfdan Sorbye
Halfdan Sorbye
Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway
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Department of Clinical Science, University of Bergen, Bergen, Norway
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Hege Elvebakken
Hege Elvebakken
Department of Oncology, Ålesund Hospital, Møre og Romsdal Hospital Trust, Ålesund, Norway
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
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Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
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Aurel Perren
Aurel Perren
Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland
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Inger Marie B Lothe
Inger Marie B Lothe
Department of Pathology, Oslo University Hospital, Oslo, Norway
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Anne Couvelard
Anne Couvelard
Department of Pathology, Université Paris Cité and AP-HP, Bichat Hospital, Paris, France
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Geir Olav Hjortland
Geir Olav Hjortland
Department of Oncology, Oslo University Hospital, Oslo, Norway
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Anna Sundlöv
Anna Sundlöv
Departmentt of Oncology, Skåne University Hospital, Lund, Sweden
Department of Medical Radiation Physics, Lund University, Lund, Sweden
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Department of Medical Radiation Physics, Lund University, Lund, Sweden
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Johanna Svensson
Johanna Svensson
Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Harrish Garresori
Harrish Garresori
Department of Oncology, Stavanger University Hospital, Stavanger, Norway
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Christian Kersten
Christian Kersten
Department of Research, Hospital of Southern Norway, Kristiansand, Norway
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Eva Hofsli
Eva Hofsli
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
Department of Oncology, St. Olavs Hospital, Trondheim, Norway
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Department of Oncology, St. Olavs Hospital, Trondheim, Norway
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Sönke Detlefsen
Sönke Detlefsen
Department of Pathology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Lene W Vestermark
Lene W Vestermark
Department of Oncology, Odense University Hospital, Odense, Denmark
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Morten Ladekarl
Morten Ladekarl
Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark
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Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark
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Elizaveta Mitkina Tabaksblat
Elizaveta Mitkina Tabaksblat
Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark
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Stian Knappskog
Stian Knappskog
K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Introduction Neuroendocrine neoplasms (NENs) constitute ~2% of all malignancies and are frequently located in the gastrointestinal (GI) tract and pancreas. High-grade gastroenteropancreatic (HG-GEP) NENs are among the most aggressive cancers
Alicia A Tone
Alicia A Tone
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
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The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
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Carl Virtanen
Carl Virtanen
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
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Patricia A Shaw
Patricia A Shaw
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
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The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
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Theodore J Brown
Theodore J Brown
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
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The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
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epithelium (OSE), accumulating evidence provides strong support that high-grade serous adnexal cancer, commonly attributed to an ovarian origin, arises from the distal fallopian tube epithelium (FTE; Colgan et al . 2001 , Piek et al . 2001 , Finch et al
Zhigang Zhao
Zhigang Zhao
Department of Urology of Minimally Invasive Surgery Center, the First Affiliated Hospital of Guangzhou Medical College, No. 1–3, Kangda Road, Guangzhou 510230, Guangdong Province, People's Republic of China
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Guohua Zeng
Guohua Zeng
Department of Urology of Minimally Invasive Surgery Center, the First Affiliated Hospital of Guangzhou Medical College, No. 1–3, Kangda Road, Guangzhou 510230, Guangdong Province, People's Republic of China
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Introduction High-grade prostatic intraepithelial neoplasia (HGPIN) is currently accepted as a risk factor for the delayed progression to prostate cancer (PCa; Dovey et al . 2005 , Ayala & Ro 2007 , Chin et al . 2007 , Montironi et al . 2007
