Filter

Refine by collections

Refine by date

—

Refine by access

  • Print
  • Save

Search Results

You are looking at 1 - 10 of 592 items for :

  • neuroendocrine carcinoma x
  • Refine by access: All content x
Clear All
Andrew McDonald Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

Search for other papers by Andrew McDonald in
Google Scholar
PubMed Close
,
Vaidehi Avadhani Grady Memorial Hospital, Atlanta, Georgia, USA

Search for other papers by Vaidehi Avadhani in
Google Scholar
PubMed Close
,
Gabriela Oprea-Ilies Grady Memorial Hospital, Atlanta, Georgia, USA

Search for other papers by Gabriela Oprea-Ilies in
Google Scholar
PubMed Close
,
Katerina Zakka Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

Search for other papers by Katerina Zakka in
Google Scholar
PubMed Close
,
Gregory B Lesinski Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

Search for other papers by Gregory B Lesinski in
Google Scholar
PubMed Close
,
Olumide B Gbolahan Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

Search for other papers by Olumide B Gbolahan in
Google Scholar
PubMed Close
, and
Olatunji Alese Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

Search for other papers by Olatunji Alese in
Google Scholar
PubMed Close

as neuroendocrine carcinoma (NEC). There is an inverse correlation between overall survival (OS) and tumor grade, with HG NEC having the worst prognosis among GEP-NEN subtypes ( Klimstra et al. 2019 ). GEP-NECs have an aggressive natural history

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-24-0046
Volume/Issue:
Volume 31: Issue 10
Restricted access
Carmine Valenza Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy
Department of Oncology and Hemato-Oncology (DIPO), University of Milan, Milan, Italy

Search for other papers by Carmine Valenza in
Google Scholar
PubMed Close
,
Francesca Spada Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Francesca Spada in
Google Scholar
PubMed Close
,
Francesco Multinu Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Francesco Multinu in
Google Scholar
PubMed Close
,
Lavinia Benini Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Lavinia Benini in
Google Scholar
PubMed Close
,
Michele Borghesani Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Michele Borghesani in
Google Scholar
PubMed Close
,
Laura Algeri Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Laura Algeri in
Google Scholar
PubMed Close
,
Manila Rubino Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Manila Rubino in
Google Scholar
PubMed Close
,
Eleonora Pisa Division of Pathology and Laboratory Medicine, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Eleonora Pisa in
Google Scholar
PubMed Close
,
Lorenzo Gervaso Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Lorenzo Gervaso in
Google Scholar
PubMed Close
,
Chiara Alessandra Cella Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Chiara Alessandra Cella in
Google Scholar
PubMed Close
,
Silvestro Carinelli Division of Pathology and Laboratory Medicine, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Silvestro Carinelli in
Google Scholar
PubMed Close
,
Simone Bruni Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Simone Bruni in
Google Scholar
PubMed Close
,
Gabriella Schivardi Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Gabriella Schivardi in
Google Scholar
PubMed Close
,
Giuseppe Curigliano Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy
Department of Oncology and Hemato-Oncology (DIPO), University of Milan, Milan, Italy

Search for other papers by Giuseppe Curigliano in
Google Scholar
PubMed Close
,
Vanna Zanagnolo Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Vanna Zanagnolo in
Google Scholar
PubMed Close
,
Giovanni Aletti Department of Oncology and Hemato-Oncology (DIPO), University of Milan, Milan, Italy
Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Giovanni Aletti in
Google Scholar
PubMed Close
,
Nicoletta Colombo Division of Gynecologic Oncology, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy
Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy

Search for other papers by Nicoletta Colombo in
Google Scholar
PubMed Close
, and
Nicola Fazio Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

Search for other papers by Nicola Fazio in
Google Scholar
PubMed Close

Introduction High-grade neuroendocrine carcinoma of the cervix (NECC) is a rare subtype of invasive cervical carcinoma, accounting for 1.4% of all cases of cervical carcinoma and displaying an extremely aggressive biological behavior, with a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0112
Volume/Issue:
Volume 30: Issue 10
Restricted access
Nora Sahnane Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

Search for other papers by Nora Sahnane in
Google Scholar
PubMed Close
,
Daniela Furlan Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

Search for other papers by Daniela Furlan in
Google Scholar
PubMed Close
,
Matilde Monti Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

Search for other papers by Matilde Monti in
Google Scholar
PubMed Close
,
Chiara Romualdi Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

Search for other papers by Chiara Romualdi in
Google Scholar
PubMed Close
,
Alessandro Vanoli Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

Search for other papers by Alessandro Vanoli in
Google Scholar
PubMed Close
,
Emanuela Vicari Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

Search for other papers by Emanuela Vicari in
Google Scholar
PubMed Close
,
Enrico Solcia Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

Search for other papers by Enrico Solcia in
Google Scholar
PubMed Close
,
Carlo Capella Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

Search for other papers by Carlo Capella in
Google Scholar
PubMed Close
,
Fausto Sessa Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

Search for other papers by Fausto Sessa in
Google Scholar
PubMed Close
, and
Stefano La Rosa Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

Search for other papers by Stefano La Rosa in
Google Scholar
PubMed Close

Introduction High-grade (or poorly differentiated) gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) are aggressive cancers with a high propensity for distant metastases. Like the more frequent pulmonary counterparts, they have

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0410
Volume/Issue:
Volume 22: Issue 1
Free access
Igryl S Cordero-Hernandez Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by Igryl S Cordero-Hernandez in
Google Scholar
PubMed Close
,
Alicia C Ross Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by Alicia C Ross in
Google Scholar
PubMed Close
,
Arvind Dasari Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by Arvind Dasari in
Google Scholar
PubMed Close
,
Daniel M Halperin Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by Daniel M Halperin in
Google Scholar
PubMed Close
,
Beth Chasen Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by Beth Chasen in
Google Scholar
PubMed Close
, and
James C Yao Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by James C Yao in
Google Scholar
PubMed Close

). In the gastrointestinal and pancreatobiliary tracts, NEN are divided into well differentiated neuroendocrine tumors (NET) and poorly differentiated neuroendocrine carcinomas (NEC). NET are classified as G1, G2, and G3 based on tumor proliferation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0203
Volume/Issue:
Volume 31: Issue 4
Restricted access
J Hadoux Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by J Hadoux in
Google Scholar
PubMed Close
,
D Malka Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by D Malka in
Google Scholar
PubMed Close
,
D Planchard Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by D Planchard in
Google Scholar
PubMed Close
,
J Y Scoazec Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by J Y Scoazec in
Google Scholar
PubMed Close
,
C Caramella Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by C Caramella in
Google Scholar
PubMed Close
,
J Guigay Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by J Guigay in
Google Scholar
PubMed Close
,
V Boige Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by V Boige in
Google Scholar
PubMed Close
,
S Leboulleux Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by S Leboulleux in
Google Scholar
PubMed Close
,
P Burtin Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by P Burtin in
Google Scholar
PubMed Close
,
A Berdelou Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by A Berdelou in
Google Scholar
PubMed Close
,
Y Loriot Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by Y Loriot in
Google Scholar
PubMed Close
,
P Duvillard Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by P Duvillard in
Google Scholar
PubMed Close
,
C N Chougnet Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by C N Chougnet in
Google Scholar
PubMed Close
,
D Déandréis Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by D Déandréis in
Google Scholar
PubMed Close
,
M Schlumberger Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by M Schlumberger in
Google Scholar
PubMed Close
,
I Borget Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by I Borget in
Google Scholar
PubMed Close
,
M Ducreux Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by M Ducreux in
Google Scholar
PubMed Close
, and
E Baudin Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

Search for other papers by E Baudin in
Google Scholar
PubMed Close

exhibit a very heterogeneous prognosis. Pathological differentiation or grading and TNM stage are the most important prognostic factors ( Baudin 2007 ). Poorly differentiated neuroendocrine carcinomas (NECs) are characterized by a poorer outcome when

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0075
Volume/Issue:
Volume 22: Issue 3
Free access
Julien Hadoux Oncologie Endocrinienne, Département d’Imagerie, Gustave Roussy, Villejuif, France

Search for other papers by Julien Hadoux in
Google Scholar
PubMed Close
,
Thomas Walter Service d’Oncologie, ENETS Centre of Excellence, Hospices Civils de Lyon et Université de Lyon, Lyon, France

Search for other papers by Thomas Walter in
Google Scholar
PubMed Close
,
Christina Kanaan Service de Pathologie, Département de Biologie et Pathologie Médicale, Gustave Roussy, Villejuif, France

Search for other papers by Christina Kanaan in
Google Scholar
PubMed Close
,
Ségolène Hescot Département d’Oncologie, Institut Curie, Paris, France

Search for other papers by Ségolène Hescot in
Google Scholar
PubMed Close
,
Vincent Hautefeuille Service d’Hépato-gastro-entérologie et Cancérologie Digestive, CHU Amiens Picardie, Amiens, France

Search for other papers by Vincent Hautefeuille in
Google Scholar
PubMed Close
,
Marine Perrier Département d’Hépato-gastro-entérologie, CHU de Reims, Reims, France

Search for other papers by Marine Perrier in
Google Scholar
PubMed Close
,
Igor Tauveron Service d'Endocrinologie, Diabétologie et Maladies Métaboliques, CHU Clermont-Ferrand, Clermont-Ferrand, France
Laboratoire GReD, Université Clermont Auvergne, Clermont-Ferrand, France

Search for other papers by Igor Tauveron in
Google Scholar
PubMed Close
,
Sandrine Laboureau Département d’Endocrinologie-Diabétologie-Nutrition, CHU d’Angers, Angers Cedex 9, France

Search for other papers by Sandrine Laboureau in
Google Scholar
PubMed Close
,
Christine Do Cao CHU de Lille, Service d’Endocrinologie, Lille, France

Search for other papers by Christine Do Cao in
Google Scholar
PubMed Close
,
Caroline Petorin CHU Clermont-Ferrand, Service de Chirurgie Digestive et Hépatobiliaire, Clermont-Ferrand, France

Search for other papers by Caroline Petorin in
Google Scholar
PubMed Close
,
Odile Blanchet CRB, CHU d’Angers, Angers Cedex 9, France

Search for other papers by Odile Blanchet in
Google Scholar
PubMed Close
,
Matthieu Faron Département de Chirurgie, Gustave Roussy, Villejuif, France

Search for other papers by Matthieu Faron in
Google Scholar
PubMed Close
,
Emmanuelle Leteurtre CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, Université de Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277, Lille, France

Search for other papers by Emmanuelle Leteurtre in
Google Scholar
PubMed Close
,
Marie-Christine Rousselet Département de Pathologie, CHU d’Angers, Angers Cedex 9, France

Search for other papers by Marie-Christine Rousselet in
Google Scholar
PubMed Close
,
Juliette Joubert Zakeyh Laboratoire d’Anatomie Pathologique, CHU Clermont-Ferrand, Clermont-Ferrand, France

Search for other papers by Juliette Joubert Zakeyh in
Google Scholar
PubMed Close
,
Aude Marchal Service d’Anatomo-Pathologie, CHU Reims, Reims, France

Search for other papers by Aude Marchal in
Google Scholar
PubMed Close
,
Denis Chatelain Service d’Anatomo-Pathologie, CHU Amiens, Amiens, France

Search for other papers by Denis Chatelain in
Google Scholar
PubMed Close
,
Clément Beaulaton Service d’Anatomo-Pathologie, Institut Curie, Paris, France

Search for other papers by Clément Beaulaton in
Google Scholar
PubMed Close
,
Valérie Hervieu Service d’Anatomo-Pathologie, ENETS Centre of Excellence, Hospices Civils de Lyon et Université de Lyon, Lyon, France

Search for other papers by Valérie Hervieu in
Google Scholar
PubMed Close
,
Catherine Lombard-Bohas Service d’Oncologie, ENETS Centre of Excellence, Hospices Civils de Lyon et Université de Lyon, Lyon, France

Search for other papers by Catherine Lombard-Bohas in
Google Scholar
PubMed Close
,
Michel Ducreux Service d’Oncologie Digestive, Département de Médecine, Gustave Roussy, Villejuif, France
Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France

Search for other papers by Michel Ducreux in
Google Scholar
PubMed Close
,
Jean-Yves Scoazec Service de Pathologie, Département de Biologie et Pathologie Médicale, Gustave Roussy, Villejuif, France
Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France

Search for other papers by Jean-Yves Scoazec in
Google Scholar
PubMed Close
,
Eric Baudin Oncologie Endocrinienne, Département d’Imagerie, Gustave Roussy, Villejuif, France

Search for other papers by Eric Baudin in
Google Scholar
PubMed Close
,
the Groupe d’Etude des Tumeurs Endocrines (GTE)
Search for other papers by the Groupe d’Etude des Tumeurs Endocrines (GTE) in
Google Scholar
PubMed Close
, and
the ENDOCAN-RENATEN network
Search for other papers by the ENDOCAN-RENATEN network in
Google Scholar
PubMed Close

Introduction Neuroendocrine carcinomas (NECs) are highly malignant diseases, which can occur in all organs and are defined by a poorly differentiated morphology and high proliferative capacities testified by a high Ki-67 index ( Rindi et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0102
Volume/Issue:
Volume 29: Issue 10
Restricted access
O Hentic Pôle des Maladies de L'appareil Digestif, Service de Pathologie, Service de Radiologie, Service de Gastroentérologie–Pancréatologie

Search for other papers by O Hentic in
Google Scholar
PubMed Close
,
P Hammel Pôle des Maladies de L'appareil Digestif, Service de Pathologie, Service de Radiologie, Service de Gastroentérologie–Pancréatologie

Search for other papers by P Hammel in
Google Scholar
PubMed Close
,
A Couvelard Pôle des Maladies de L'appareil Digestif, Service de Pathologie, Service de Radiologie, Service de Gastroentérologie–Pancréatologie

Search for other papers by A Couvelard in
Google Scholar
PubMed Close
,
V Rebours Pôle des Maladies de L'appareil Digestif, Service de Pathologie, Service de Radiologie, Service de Gastroentérologie–Pancréatologie

Search for other papers by V Rebours in
Google Scholar
PubMed Close
,
M Zappa Pôle des Maladies de L'appareil Digestif, Service de Pathologie, Service de Radiologie, Service de Gastroentérologie–Pancréatologie

Search for other papers by M Zappa in
Google Scholar
PubMed Close
,
M Palazzo Pôle des Maladies de L'appareil Digestif, Service de Pathologie, Service de Radiologie, Service de Gastroentérologie–Pancréatologie

Search for other papers by M Palazzo in
Google Scholar
PubMed Close
,
F Maire Pôle des Maladies de L'appareil Digestif, Service de Pathologie, Service de Radiologie, Service de Gastroentérologie–Pancréatologie

Search for other papers by F Maire in
Google Scholar
PubMed Close
,
G Goujon Pôle des Maladies de L'appareil Digestif, Service de Pathologie, Service de Radiologie, Service de Gastroentérologie–Pancréatologie

Search for other papers by G Goujon in
Google Scholar
PubMed Close
,
A Gillet Pôle des Maladies de L'appareil Digestif, Service de Pathologie, Service de Radiologie, Service de Gastroentérologie–Pancréatologie

Search for other papers by A Gillet in
Google Scholar
PubMed Close
,
P Lévy Pôle des Maladies de L'appareil Digestif, Service de Pathologie, Service de Radiologie, Service de Gastroentérologie–Pancréatologie

Search for other papers by P Lévy in
Google Scholar
PubMed Close
, and
P Ruszniewski Pôle des Maladies de L'appareil Digestif, Service de Pathologie, Service de Radiologie, Service de Gastroentérologie–Pancréatologie

Search for other papers by P Ruszniewski in
Google Scholar
PubMed Close

condition due to aggressive and diffuse disease. These tumors are characterized by aggressive histological features (high Ki-67 index, extensive necrosis, and nuclear atypia) and are classified as neuroendocrine carcinomas (NECs) grade 3 according to the new

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0002
Volume/Issue:
Volume 19: Issue 6
Free access
Sara Molatore Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

Search for other papers by Sara Molatore in
Google Scholar
PubMed Close
,
Andrea Kügler Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

Search for other papers by Andrea Kügler in
Google Scholar
PubMed Close
,
Martin Irmler Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany

Search for other papers by Martin Irmler in
Google Scholar
PubMed Close
,
Tobias Wiedemann Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

Search for other papers by Tobias Wiedemann in
Google Scholar
PubMed Close
,
Frauke Neff Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany

Search for other papers by Frauke Neff in
Google Scholar
PubMed Close
,
Annette Feuchtinger Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany

Search for other papers by Annette Feuchtinger in
Google Scholar
PubMed Close
,
Johannes Beckers Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany
Technische Universität München, Chair of Experimental Genetics, Freising, Germany

Search for other papers by Johannes Beckers in
Google Scholar
PubMed Close
,
Mercedes Robledo Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO) and ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain

Search for other papers by Mercedes Robledo in
Google Scholar
PubMed Close
,
Federico Roncaroli Division of Neuroscience and Experimental Psychology, Faculty of Medicine, University of Manchester, Manchester, UK

Search for other papers by Federico Roncaroli in
Google Scholar
PubMed Close
, and
Natalia S Pellegata Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

Search for other papers by Natalia S Pellegata in
Google Scholar
PubMed Close

suppressor ( Fero et al. 1996 , Kiyokawa et al. 1996 , Nakayama et al . 1996 ). Recently, a role for p27 in the pathogenesis of neuroendocrine tumors (NETs) has emerged. A spontaneous homozygous germline frameshift mutation in Cdkn1b encoding an

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0456
Volume/Issue:
Volume 25: Issue 2
Free access
Jessica L Geiger Division of Hematology/Oncology, Department of Internal Medicine, University of Pittsburgh Cancer Institute, Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Pittsburgh Medical Center, Division of Molecular Genomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, 5150 Centre Avenue, 5th Floor, Pittsburgh, Pennsylvania, 15232, USA

Search for other papers by Jessica L Geiger in
Google Scholar
PubMed Close
,
Simion I Chiosea Division of Hematology/Oncology, Department of Internal Medicine, University of Pittsburgh Cancer Institute, Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Pittsburgh Medical Center, Division of Molecular Genomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, 5150 Centre Avenue, 5th Floor, Pittsburgh, Pennsylvania, 15232, USA

Search for other papers by Simion I Chiosea in
Google Scholar
PubMed Close
,
Sue M Challinor Division of Hematology/Oncology, Department of Internal Medicine, University of Pittsburgh Cancer Institute, Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Pittsburgh Medical Center, Division of Molecular Genomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, 5150 Centre Avenue, 5th Floor, Pittsburgh, Pennsylvania, 15232, USA

Search for other papers by Sue M Challinor in
Google Scholar
PubMed Close
,
Marina N Nikiforova Division of Hematology/Oncology, Department of Internal Medicine, University of Pittsburgh Cancer Institute, Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Pittsburgh Medical Center, Division of Molecular Genomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, 5150 Centre Avenue, 5th Floor, Pittsburgh, Pennsylvania, 15232, USA

Search for other papers by Marina N Nikiforova in
Google Scholar
PubMed Close
, and
Julie E Bauman Division of Hematology/Oncology, Department of Internal Medicine, University of Pittsburgh Cancer Institute, Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Pittsburgh Medical Center, Division of Molecular Genomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, 5150 Centre Avenue, 5th Floor, Pittsburgh, Pennsylvania, 15232, USA

Search for other papers by Julie E Bauman in
Google Scholar
PubMed Close

). Tumor formation occurs in the neuroendocrine organs where constitutively activated RET is expressed. Although neuroendocrine carcinoma (NEC) of the lung has been described in MEN 1 ( Farhandi et al . 1987 ), it has not been described in the MEN2

Article Type:
Editorial
DOI:
https://doi.org/10.1530/ERC-15-0307
Volume/Issue:
Volume 22: Issue 5
Free access
Atsuko Kasajima Department of Pathology, Technical University Munich, Munich, Germany
Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan

Search for other papers by Atsuko Kasajima in
Google Scholar
PubMed Close
,
Yuichi Ishikawa Pathology Department, The Cancer Institute Hospital of JFCR, Tokyo, Japan

Search for other papers by Yuichi Ishikawa in
Google Scholar
PubMed Close
,
Ayaka Iwata Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan

Search for other papers by Ayaka Iwata in
Google Scholar
PubMed Close
,
Katja Steiger Department of Pathology, Technical University Munich, Munich, Germany

Search for other papers by Katja Steiger in
Google Scholar
PubMed Close
,
Naomi Oka Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
National Hospital Organization, Sendai Medical Center, Sendai, Japan

Search for other papers by Naomi Oka in
Google Scholar
PubMed Close
,
Hirotaka Ishida Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan

Search for other papers by Hirotaka Ishida in
Google Scholar
PubMed Close
,
Akira Sakurada Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University Graduate School of Medicine, Sendai, Japan

Search for other papers by Akira Sakurada in
Google Scholar
PubMed Close
,
Hiroyoshi Suzuki National Hospital Organization, Sendai Medical Center, Sendai, Japan

Search for other papers by Hiroyoshi Suzuki in
Google Scholar
PubMed Close
,
Toru Kameya Division of Pathology, Shizuoka Cancer Center Hospital and Research Institute, Sizuoka, Japan

Search for other papers by Toru Kameya in
Google Scholar
PubMed Close
,
Björn Konukiewitz Department of Pathology, Technical University Munich, Munich, Germany

Search for other papers by Björn Konukiewitz in
Google Scholar
PubMed Close
,
Günter Klöppel Department of Pathology, Technical University Munich, Munich, Germany

Search for other papers by Günter Klöppel in
Google Scholar
PubMed Close
,
Yoshinori Okada Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University Graduate School of Medicine, Sendai, Japan

Search for other papers by Yoshinori Okada in
Google Scholar
PubMed Close
,
Hironobu Sasano Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan

Search for other papers by Hironobu Sasano in
Google Scholar
PubMed Close
, and
Wilko Weichert Department of Pathology, Technical University Munich, Munich, Germany
Member of the German Cancer Consortium (DKTK)

Search for other papers by Wilko Weichert in
Google Scholar
PubMed Close

Introduction Pulmonary neuroendocrine tumors, as defined in the 2015 classification of the World Health Organization (WHO), comprise three different types; carcinoid tumors, large cell neuroendocrine carcinomas (LCNEC) and small-cell lung

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0427
Volume/Issue:
Volume 25: Issue 3
Free access