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André Wendindondé Nana PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei, Taiwan

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Yu-Tang Chin PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan

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Chi-Yu Lin Center for Teeth Bank and Dental Stem Cell Technology and School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan

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Yih Ho School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan

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James A Bennett Center for Immunology and Microbial Diseases, Albany Medical College, Albany, New York, USA

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Ya-Jung Shih Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan

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Yi-Ru Chen Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan

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Chun A Changou PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei, Taiwan
Integrated Laboratory, Center of Translational Medicine, Core Facility, Taipei Medical University, Taipei, Taiwan

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Jens Z Pedersen Department of Biology, University Tor Vergata, Rome, Italy

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Sandra Incerpi Department of Sciences, University Roma Tre, Rome, Italy

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Leroy F Liu Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan

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Jacqueline Whang-Peng Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan

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Earl Fu Department of Dentistry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan

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Wen-Shan Li Laboratory of Chemical Biology and Medicinal Chemistry, Institute of Chemistry, Academia Sinica, Taipei, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University, Taipei, Taiwan

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Shaker A Mousa Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York, USA

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Hung-Yun Lin PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan
Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York, USA
Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan

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Paul J Davis Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York, USA
Department of Medicine, Albany Medical College, Albany, New York, USA

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of relapse, which often leads to patients’ death. Novel therapeutic approaches are needed for this disease. The molecular pathogenesis of colon cancer encompasses the activation of several oncogenic signaling pathways, including the Wnt/β-catenin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0450
Volume/Issue:
Volume 25: Issue 3
Free access
Sayantani Sarkar
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Chandan Mandal
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Rajender Sangwan Cancer Biology and Inflammatory Disorder Division, Bio-Processing Unit, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, 4, Raja S.C. Mallick Road, Kolkata 700032, West Bengal, India

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Chitra Mandal
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Introduction Aberrant Wnt/β-catenin signaling is often observed in various cancers ( Polakis 2000 , Moon et al . 2002 , Lustig & Behrens 2003 ). β-catenin is a ubiquitously expressed protein with multiple functions. Initially, this protein was

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0315
Volume/Issue:
Volume 21: Issue 1
Free access
Juan A Ardura Bone Physiopathology Laboratory, Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, CEU Universities, Campus Monteprincipe, Madrid, Spain
Departamento de Ciencias Médicas Básicas, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Campus Monteprincipe, Madrid, Spain

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Luis Álvarez-Carrión Bone Physiopathology Laboratory, Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, CEU Universities, Campus Monteprincipe, Madrid, Spain

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Irene Gutiérrez-Rojas Bone Physiopathology Laboratory, Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, CEU Universities, Campus Monteprincipe, Madrid, Spain

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Peter A Friedman Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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Arancha R Gortázar Bone Physiopathology Laboratory, Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, CEU Universities, Campus Monteprincipe, Madrid, Spain
Departamento de Ciencias Médicas Básicas, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Campus Monteprincipe, Madrid, Spain

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Verónica Alonso Bone Physiopathology Laboratory, Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, CEU Universities, Campus Monteprincipe, Madrid, Spain
Departamento de Ciencias Médicas Básicas, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Campus Monteprincipe, Madrid, Spain

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regulating bone morphogenetic proteins or the Wnt/β-catenin signaling pathway ( Friedman et al. 2009 , Palmer et al. 2014 , Zhu et al. 2016 ). However, no previous reports describe the effects of MINDIN on bone or whether a crosstalk between MINDIN

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0116
Volume/Issue:
Volume 27: Issue 7
Free access
Yi Li Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA
Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Yichun Zheng Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA
Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Koji Izumi Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Hitoshi Ishiguro Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Bo Ye Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Faqian Li Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Hiroshi Miyamoto Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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mechanism by which AR signaling modulates bladder cancer progression remains poorly understood. The canonical Wnt/β-catenin signaling pathway has been shown to play a pivotal role in normal cell growth and differentiation, embryonic development, and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0328
Volume/Issue:
Volume 20: Issue 3
Free access
Julie Le Mestre Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France

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Michaël Thomas Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France

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Céline Duparc Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France

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Pierre Val CNRS, UMR 6293, GReD, Inserm U1103, Université Clermont Auvergne, Clermont-Ferrand, France

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Clémence Bures Department of Diabetes, Endocrinology and Metabolic Diseases, Groupe Hospitalier du Havre, Montivilliers, France

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Jean-Jacques Tuech Department of Digestive Surgery, Rouen University Hospital, Rouen, France

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Jean-Christophe Sabourin Department of Pathology, Rouen University Hospital, Rouen, France
Centre for Biological Resources, Rouen University Hospital, Rouen, France

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Stéphanie Baert-Desurmont Department of Genetics, Rouen University Hospital, Rouen, France

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Hervé Lefebvre Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France
Centre for Biological Resources, Rouen University Hospital, Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Rouen University Hospital, Rouen, France
Clinical Investigation Centre, INSERM, CIC1404, Rouen University Hospital, Rouen, France

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Estelle Louiset Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France

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as the major cause of the development of benign cortisol-producing lesions ( Beuschlein et al. 2014 , Hannah-Shmouni et al. 2016 , Espiard et al. 2018 , Kamilaris et al. 2020 ). In addition, insulin-like growth factor 2, TP53 and β-catenin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0298
Volume/Issue:
Volume 29: Issue 3
Restricted access
F Cetani Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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E Pardi Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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C Banti Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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P Collecchi Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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P Viacava Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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S Borsari Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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G Fanelli Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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A G Naccarato Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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F Saponaro Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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P Berti Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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P Miccoli Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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A Pinchera Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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C Marcocci Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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). HRPT2 encodes a protein of 531 amino acids called parafibromin. Parafibromin is a tumor suppressor protein and has recently been linked to Wnt/β catenin pathway ( Mosimann et al . 2006 ). Activation of the Wnt/β-catenin pathway is involved in a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0147
Volume/Issue:
Volume 17: Issue 1
Free access
María Jesús Larriba
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Noelia Valle
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Héctor G Pálmer
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Paloma Ordóñez-Morán
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Silvia Álvarez-Díaz
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Karl-Friedrich Becker
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Carlos Gamallo
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Antonio García de Herreros
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José Manuel González-Sancho
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Alberto Muñoz
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analogues with reduced calcemic properties are being used in pre-clinical studies and clinical trials against colon cancer and other neoplasias. Colon cancer is one of the most frequent neoplasias and a major health problem worldwide. Wnt/β-catenin

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-06-0028
Volume/Issue:
Volume 14: Issue 1
Free access
Silvia Pizzi
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Cinzia Azzoni
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Elisa Tamburini
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Lorena Bottarelli
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Nicoletta Campanini
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Tiziana D'Adda
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Giovanni Fellegara
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Tu Vinh Luong
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Claudio Pasquali Section of Pathological Anatomy, Department of Medical and Surgical Sciences, Section of Pathology, Digestive and Liver Disease Unit, Medical Oncology Unit, Department of Pathology and Laboratory Medicine, University of Parma, via Gramsci, 14, I-43100 Parma, Italy

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Giulio Rossi Section of Pathological Anatomy, Department of Medical and Surgical Sciences, Section of Pathology, Digestive and Liver Disease Unit, Medical Oncology Unit, Department of Pathology and Laboratory Medicine, University of Parma, via Gramsci, 14, I-43100 Parma, Italy

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Gianfranco Delle Fave Section of Pathological Anatomy, Department of Medical and Surgical Sciences, Section of Pathology, Digestive and Liver Disease Unit, Medical Oncology Unit, Department of Pathology and Laboratory Medicine, University of Parma, via Gramsci, 14, I-43100 Parma, Italy

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Roberta Camisa Section of Pathological Anatomy, Department of Medical and Surgical Sciences, Section of Pathology, Digestive and Liver Disease Unit, Medical Oncology Unit, Department of Pathology and Laboratory Medicine, University of Parma, via Gramsci, 14, I-43100 Parma, Italy

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Cesare Bordi
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Guido Rindi
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, located on chromosome 5q21-22, is mutated in the majority of colon cancers and acts as antagonist of the Wnt signalling pathway. The loss of APC function leads to the stabilization of β-catenin in the cytoplasm, followed by its migration in the nucleus

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0230
Volume/Issue:
Volume 15: Issue 4
Free access
Ming-Chuan Hsu
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Hui-Chiu Chang
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Wen-Chun Hung
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vector was provided by Dr Hung MC (MD Anderson Cancer Center, USA). Human β-catenin expression vector was obtained from Dr Wang CH (Kaohsiung Medical University, Taiwan). Dominant-negative ERK2 expression vector was obtained from Dr Lin WW (National

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0077
Volume/Issue:
Volume 14: Issue 3
Free access
David L Vesely Division of Endocrinology, Diabetes and Metabolism, Departments of Medicine, Molecular Pharmacology and Physiology, James A. Haley VA Medical Center-151, University of South Florida Cardiac Hormone Center, and University of South Florida Morsani School of Medicine, 13000 Bruce B. Downs Boulevard, Tampa, Florida 33612, USA

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within cancer cells are VEGF, the VEGFR2 receptor, β-catenin, secreted frizzled receptor, JNK, STAT3, and the WNT pathway. RTK, tyrosine kinase receptor; SRC, rous sarcoma viral proto-oncogene tyrosine kinase; SHC, rous sarcoma SH2 C-terminal binding

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0054
Volume/Issue:
Volume 20: Issue 3
Free access