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Xiaqing Xu, Meimei Si, Honggang Lou, Youyou Yan, Yunxi Liu, Hong Zhu, Xiaoe Lou, Jian Ma, Difeng Zhu, Honghai Wu, Bo Yang, Haoshu Wu, Ling Ding and Qiaojun He

treatment. Whether hyperglycemia is associated with decreased sensitivity to ADR remained unknown. AMP-activated protein kinase (AMPK) is originally well known as a key sensor of fuel that regulates metabolism and energy homeostasis ( Kim et al . 2014 b

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Luca Varinelli, Dario Caccia, Chiara C Volpi, Claudio Caccia, Maida De Bortoli, Elena Taverna, Ambra V Gualeni, Valerio Leoni, Annunziata Gloghini, Giacomo Manenti and Italia Bongarzone

-receptors ( Klasen et al . 2014 ). Recent findings indicated that MIF binding to CD74 stimulated heart and muscle glucose uptake, and that the autocrine/paracrine effects of endogenous cardiac MIF contributed to AMP-activated protein kinase (AMPK) activation and

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Barbara Salani, Alberto Del Rio, Cecilia Marini, Gianmario Sambuceti, Renzo Cordera and Davide Maggi

key regulator of cellular metabolism. It has been reported that metformin inhibits proliferation and induces apoptosis in cancer cells as a result of decreased energy disposition due to an increased AMP:ATP ratio and AMP-activated protein kinase (AMPK

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D Barb, A Neuwirth, C S Mantzoros and S P Balk

and increases fatty acid oxidation through phosphorylation and activation of AMP-activated protein kinase (AMPK; Berg et al . 2001 , Yamauchi et al . 2002 , Wang et al . 2007 ), p38 MAP kinase activation, and peroxisome proliferator

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K M Biernacka, R A Persad, A Bahl, D Gillatt, J M P Holly and C M Perks

kinase (AMPK). In response to low energy levels or cellular stress, a conformational change is induced in the AMPKγ regulatory subunit that results in the exposure of the AMPKα catalytic subunit to phosphorylation of threonine residue (Thr-172) by liver

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Joanna Klubo-Gwiezdzinska, Kirk Jensen, John Costello, Aneeta Patel, Victoria Hoperia, Andrew Bauer, Kenneth D Burman, Leonard Wartofsky and Vasyl Vasko

network interactions reveals that both MEK/ERK and mTOR/p70S6K pathways can be inhibited by 5′-AMP-activated protein kinase (AMPK). AMPK directly phosphorylates the TSC2 tumor suppressor on conserved serine sites distinct from those targeted by other

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Carolyn Algire, Lilian Amrein, Mahvash Zakikhani, Lawrence Panasci and Michael Pollak

favorably influences cancer outcomes ( Evans et al . 2005 , Bowker et al . 2006 ). The drug acts by impairing oxidative phosphorylation, which increases the intracellular AMP/ATP ratio, leading to the activation of the LKB1–AMPK signaling pathway

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Mark A White, Efrosini Tsouko, Chenchu Lin, Kimal Rajapakshe, Jeffrey M Spencer, Sandi R Wilkenfeld, Sheiva S Vakili, Thomas L Pulliam, Dominik Awad, Fotis Nikolos, Rajasekhara Reddy Katreddy, Benny Abraham Kaipparettu, Arun Sreekumar, Xiaoliu Zhang, Edwin Cheung, Cristian Coarfa and Daniel E Frigo

signaling cascade involving the calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the 5′-AMP-activated protein kinase (AMPK) ( Massie et al. 2011 , Tennakoon et al. 2014 ). Given the requirement for initial glucose uptake prior to its

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Shih-Ping Cheng, Chien-Liang Liu, Ming-Jen Chen, Ming-Nan Chien, Ching-Hsiang Leung, Chi-Hsin Lin, Yi-Chiung Hsu and Jie-Jen Lee

), total AMPK (#2532; Cell Signaling), and β-actin (Sigma) at 4 °C overnight. The results were visualized by chemiluminescence with the Amersham ECL Detection System (GE Healthcare, Piscataway, NJ, USA). The blot signals were quantified by densitometry

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Hyun-Seuk Moon and Christos S Mantzoros

(Billerica, MA, USA). Mouse monoclonal p-STAT3 (target site at Tyr 705), rabbit polyclonal STAT3, rabbit polyclonal p-AMPK (target site at Tyr 172), rabbit polyclonal AMPK, mouse monoclonal p-LKB1 (target site at Ser 431), goat polyclonal LKB1, rabbit