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Lundberg Laboratory for Cancer Research, Department of Zoology, Department of Neuroscience and Physiology, Lundberg Laboratory for Cancer Research, Department of Pathology and Cytology, Sahlgrenska Academy, University of Göteborg, Gula Stråket 8, SE-413 45 Göteborg, Sweden
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membrane integrity, angiogenesis and haematopoiesis ( Semenza 2003 ). The chemokine CXCL12 (stromal cell-derived factor 1 (SDF-1)) and its receptor C-X-C chemokine receptor type 4 (CXCR4) are known to regulate the homing process of haematopoietic cells as
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signalling via its cognate receptor, chemokine (C-X-C motif) receptor 4 (CXCR4) stimulates tumour cells proliferation and neoangiogenesis by recruiting circulating endothelial progenitor cells into the tumour stroma ( Kojima et al . 2010 ). TAFs are thought
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PHD Course in Experimental Medicine, University of Pavia, Pavia, Italy
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Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
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Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
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, CXCR3, CXCR4, CXCR7, DARC, CCR3, CCR6 and CCR7 ( Fig. 2 ). Table 1 summarizes our current knowledge on the role of these receptors in thyroid cancer. Table 1 Chemokine receptors expression and role in thyroid cancer. Chemokine
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Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
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Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
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-associated phenotype. In addition, we identified the chemokine (C-X-C motif) receptor 4 (Cxcr4) pathway as an interesting target for further investigation in pituitary tumor treatment. Materials and methods Pituitary adenomas Human pituitary adenoma samples were
INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France
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INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France
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INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France
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, strongly enhancing leukocyte migration. The inflammatory chemokine CXCL8, for example, can potentiate responses induced by CCL2 and CXCL12, which act on CCR1 and CXCR4 respectively, but not with CCL21, which triggers responses through CCR7 ( Gouwy et al
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Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples ‘Federico II’, Naples, Italy
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TME into a cancer-promoting context ( Kalluri 2016 ). In breast cancer, CAFs produce the chemokine CXCL12/SDF-1, that can recruit endothelial progenitor cells into the tumor mass thus promoting angiogenesis; SDF-1 can directly stimulate the CXCR4
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et al . 2006 ). In some immune processes, MIF acts as a non-cognate ligand of chemokine receptors, CXCR2 and CXCR4. Biochemical evidence suggests that, upon MIF stimulation, these receptors may act as additional, signal-transducing CD74 co
Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
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Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
Section of Urology, Department of Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
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known ligands including HB-EGF, BTC, EPR, EGF, TGF-α, EPG and AREG. ErbB-2 can be activated via CXCR4 when this protein is bound to its ligand, CXCL12, via Src kinase. Interestingly, ErbB-2 can also promote the activation of CXCR4 as well. Negative
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, this receptor has been reclassified recently as chemokine receptor 4 (CXCR4), a well-characterized receptor ( Bleul et al . 1996 ). The receptors Y1, Y2, Y4, and Y5 were characterized in the human adrenal medulla, but no data are available regarding
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Department of Hematology, Department of Experimental Oncology, Oncology and Molecular Medicine, Istituto Superiore Sanità, viale Regina Elena 299, 00161 Rome, Italy
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macrophage colony-stimulating factor (M-CSF) cytokine production to facilitate osteolytic metastasis ( Bourguignon et al . 2003 ). Interestingly, it has been demonstrated that miR-146 inhibits the translation of the SDF-1 receptor CXCR4, and that