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R van der Pas, W W de Herder, L J Hofland, and R A Feelders

Introduction Cushing's syndrome (CS) is characterized by chronic overproduction of cortisol resulting in significant morbidity and, when untreated, an increased mortality ( Lindholm et al . 2001 , Newell-Price et al . 2006 , Dekkers et al

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Andrew E Greenstein, Mouhammed Amir Habra, Subhagya A Wadekar, and Andreas Grauer

suppress tumor cell killing by human NK cells in vitro . Discussion ACC is a grievous disease in which patients face challenges both in tumor and hormone management. ACC patients with GC excess experience Cushing syndrome, which by itself can

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Evgenia Gourgari, Maya Lodish, Meg Keil, Robert Wesley, Suvimol Hill, Paraskevi Xekouki, Charalampos Lyssikatos, Elena Belyavskaya, Sierra Maria De La Luz, and Constantine A Stratakis

Dear Editor, Cushing's syndrome (CS) is a rare disease in children it is associated with weight gain and stunting of their linear growth ( McArthur et al . 1980 , Magiakou et al . 1994 a , Stratakis 2012 ). In this study, we assessed growth in

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Carole Guerin, David Taieb, Giorgio Treglia, Thierry Brue, André Lacroix, Frederic Sebag, and Frederic Castinetti

Introduction Hypercortisolism or Cushing's syndrome (CS) is a rare condition; effective treatments are necessary because of an increased morbidity and mortality if left untreated. CS can be due to: i) an excess of adrenocorticotrophin (ACTH

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E Louiset, K Isvi, J M Gasc, C Duparc, B Cauliez, A Laquerrière, J M Kuhn, and H Lefebvre

hyperplasias (AIMAHs) and adenomas responsible for Cushing's syndrome ( Bertherat et al . 2005 , Contesse et al . 2005 ). In these lesions, 5-HT is abnormally detected in clusters of steroidogenic cells that harbor therefore a mixed, i.e. both steroidogenic

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Sisi Liu, Emmanouil Saloustros, Annabel Berthon, Matthew F Starost, Isabelle Sahut-Barnola, Paraskevi Salpea, Eva Szarek, Fabio R Faucz, Antoine Martinez, and Constantine A Stratakis

Introduction Primary pigmented nodular adrenocortical disease (PPNAD) leads to adrenocorticotropin hormone (ACTH)-independent Cushing's syndrome (CS) ( Carney et al . 1985 , Stratakis 2007 ) and is caused typically by inactivating mutations of

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Patricia de Cremoux, Dan Rosenberg, Jacques Goussard, Catherine Brémont-Weil, Frédérique Tissier, Carine Tran-Perennou, Lionnel Groussin, Xavier Bertagna, Jérôme Bertherat, and Marie-Laure Raffin-Sanson

than men ( Luton et al . 1990 ). The prevalence of adrenocortical tumors is particularly high during pregnancy, accounting for 70% of all cases of Cushing's syndrome (CS) diagnosed in pregnant women ( Guilhaume et al . 1992 , Lindsay & Nieman 2006

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Fady Hannah-Shmouni, Annabel Berthon, Fabio R Faucz, Juan Medina Briceno, Andrea Gutierrez Maria, Andrew Demidowich, Mirko Peitzsch, Jimmy Masjkur, Fidéline Bonnet-Serrano, Anna Vaczlavik, Jérôme Bertherat, Martin Reincke, Graeme Eisenhofer, and Constantine A Stratakis

Introduction Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a rare form of adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome (CS), responsible for <1% of endogenous hypercortisolemia ( Stratakis

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Y de Keyzer, D Vieau, A Picon, and X Bertagna

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A L Ogilvy-Stuart and S M Shalet