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Liyan Zhou Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Guiying Bai Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yue Song Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xiaohui Liu Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xiaoqing Li Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yilin Deng Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yiran Si Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yehui Shi Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Hongli Li Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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increased demethylation of its promoter ( Zhou et al. 2019 ). However, the molecular mechanisms underlying active DNA demethylation of the MMP-9 promoter are complex and have not yet been clarified in breast cancer patients with diabetes. Here, the roles

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0330
Volume/Issue:
Volume 31: Issue 9
Restricted access
Antoinette S Perry
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Ruth Foley
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Karen Woodson
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Mark Lawler
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during replication, leading to synthesis of nascent DNA in the absence of DNMT activity, resulting in DNA demethylation ( Taylor & Jones 1982 , Friedman 1985 ). The administration of these drugs causes multiple changes as a consequence of demethylation

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.01184
Volume/Issue:
Volume 13: Issue 2
Free access
Carles Zafon Diabetes and Metabolism Research Unit (VHIR) and Department of Endocrinology, University Hospital Vall d’Hebron and Autonomous University of Barcelona, Barcelona, Spain
Consortium for the Study of Thyroid Cancer (CECaT), Catalonia, Spain

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Joan Gil Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Barcelona, Spain

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Beatriz Pérez-González Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Barcelona, Spain

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Mireia Jordà Consortium for the Study of Thyroid Cancer (CECaT), Catalonia, Spain
Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Barcelona, Spain

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the 5mC pattern on the newly synthesized strand after DNA replication. DNA demethylation can occur through different mechanisms: passive demethylation due to the impairment of the DNA methylation maintenance machinery that results in the dilution of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0093
Volume/Issue:
Volume 26: Issue 7
Free access
Thomas J Sweet Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Angela H Ting Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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133 3411 – 3418 . ( doi:10.1242/dev.02500 ) Maeder ML Angstman JF Richardson ME Linder SJ Cascio VM Tsai SQ Ho QH Sander JD Reyon D Bernstein BE 2013 Targeted DNA demethylation and activation of endogenous

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0306
Volume/Issue:
Volume 23: Issue 11
Free access
Ana B Crujeiras Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain
Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela University (USC), Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain

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Angel Diaz-Lagares Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain
Translational Medical Oncology Group (Oncomet), Instituto de Investigación Sanitaria (IDIS); Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) and CIBER de Cancer (CIBERONC), Santiago de Compostela, Spain

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Olafur A Stefansson Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain
Cancer Research Laboratory, Faculty of Medicine, University of Iceland, Reykjavic, Iceland

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Manuel Macias-Gonzalez CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain
Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Complejo Hospitalario de Málaga (Virgen de la Victoria), Universidad de Málaga, Málaga, Spain

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Juan Sandoval Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain

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Juan Cueva Translational Medical Oncology Group (Oncomet), Instituto de Investigación Sanitaria (IDIS); Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) and CIBER de Cancer (CIBERONC), Santiago de Compostela, Spain

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Rafael Lopez-Lopez Translational Medical Oncology Group (Oncomet), Instituto de Investigación Sanitaria (IDIS); Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) and CIBER de Cancer (CIBERONC), Santiago de Compostela, Spain

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Sebastian Moran Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain

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Jon G Jonasson Department of Pathology and the Icelandic Cancer Registry, Icelandic Cancer society and Landspitali University Hospital, Reykjavik, Iceland

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Laufey Tryggvadottir Department of Pathology and the Icelandic Cancer Registry, Icelandic Cancer society and Landspitali University Hospital, Reykjavik, Iceland

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Elinborg Olafsdottir Department of Pathology and the Icelandic Cancer Registry, Icelandic Cancer society and Landspitali University Hospital, Reykjavik, Iceland

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Francisco J Tinahones CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain
Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Complejo Hospitalario de Málaga (Virgen de la Victoria), Universidad de Málaga, Málaga, Spain

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Marcos C Carreira Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela University (USC), Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain

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Felipe F Casanueva Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela University (USC), Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain

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Manel Esteller Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain
Department of Physiological Sciences II, School of Medicine, University of Barcelona and Instituto Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain

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tumors is affected by a complex interaction between BMI and menopausal status. Thus, patients with breast cancer associated with the described DNA methylation markers might also receive DNA demethylation agents as co-adjuvant therapy to the standard

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0565
Volume/Issue:
Volume 24: Issue 7
Free access
Charles E Massie Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Inmaculada Spiteri Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Helen Ross-Adams Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Hayley Luxton Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Jonathan Kay Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Hayley C Whitaker Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Mark J Dunning Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Alastair D Lamb Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Antonio Ramos-Montoya Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Daniel S Brewer Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Colin S Cooper Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Rosalind Eeles Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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UK Prostate ICGC Group
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Anne Y Warren Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Simon Tavaré Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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David E Neal Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Andy G Lynch Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Hes5 expression by active DNA demethylation and induce neural stem cells . Nature Neuroscience 14 957 – 964 . ( doi:10.1038/nn.2875 ). Jacobsen KX Vanderluit JL Slack RS Albert PR 2008 HES1 regulates 5-HT1A receptor gene transcription

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0454
Volume/Issue:
Volume 22: Issue 2
Open access
Carl Weidinger Division of Endocrinology and Diabetology, Department of Internal Medicine, University of Leipzig, Philipp-Rosenthal-Strasse 27, D-04103 Leipzig, Germany

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Kerstin Krause Division of Endocrinology and Diabetology, Department of Internal Medicine, University of Leipzig, Philipp-Rosenthal-Strasse 27, D-04103 Leipzig, Germany

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Antje Klagge Division of Endocrinology and Diabetology, Department of Internal Medicine, University of Leipzig, Philipp-Rosenthal-Strasse 27, D-04103 Leipzig, Germany

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Stefan Karger Division of Endocrinology and Diabetology, Department of Internal Medicine, University of Leipzig, Philipp-Rosenthal-Strasse 27, D-04103 Leipzig, Germany

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Dagmar Fuhrer Division of Endocrinology and Diabetology, Department of Internal Medicine, University of Leipzig, Philipp-Rosenthal-Strasse 27, D-04103 Leipzig, Germany

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by the capability of FOXO3a and FOXO4 to induce the transcription of Gadd45a, which harbours base excision activity and maintains genomic integrity, e.g. through DNA demethylation and cell cycle control ( Hollander et al . 1999 , Smith et al . 2000

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0153
Volume/Issue:
Volume 15: Issue 4
Free access
Kevin C Knower Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia

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Sarah Q To Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia

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Yuet-Kin Leung Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia

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Shuk-Mei Ho Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia

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Colin D Clyne Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia

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patterns to a lesser degree ( Hermann et al . 2004 ). Mechanisms of DNA demethylation have more recently been uncovered, with the present model outlining both passive and active methods of demethylating CpG sites. Passive demethylation occurs when an error

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0513
Volume/Issue:
Volume 21: Issue 2
Free access
Tanya K Day
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Tina Bianco-Miotto Dame Roma Mitchell Cancer Research Laboratories, School of Paediatrics and Reproductive Health, School of Agriculture, Discipline of Medicine, Hanson Institute, Adelaide Prostate Cancer Research Centre, The University of Adelaide, Adelaide, South Australia, Australia
Dame Roma Mitchell Cancer Research Laboratories, School of Paediatrics and Reproductive Health, School of Agriculture, Discipline of Medicine, Hanson Institute, Adelaide Prostate Cancer Research Centre, The University of Adelaide, Adelaide, South Australia, Australia

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targets for anticancer therapy . Biochemistry 70 533 – 549 . ( doi:10.1007/s10541-005-0147-7 ). Szyf M Pakneshan P Rabbani SA 2004 DNA demethylation and cancer: therapeutic implications . Cancer Letters 211 133 – 143 . ( doi:10.1016/j

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0204
Volume/Issue:
Volume 20: Issue 5
Free access
Zijie Feng Department of Cancer Biology Abramson Family Cancer Research Institute, Abramson Cancer Center, Institute of Diabetes, Obesity, and Metabolism (IDOM), University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Jian Ma Department of Cancer Biology Abramson Family Cancer Research Institute, Abramson Cancer Center, Institute of Diabetes, Obesity, and Metabolism (IDOM), University of Pennsylvania, Philadelphia, Pennsylvania, USA
State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China

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Xianxin Hua Department of Cancer Biology Abramson Family Cancer Research Institute, Abramson Cancer Center, Institute of Diabetes, Obesity, and Metabolism (IDOM), University of Pennsylvania, Philadelphia, Pennsylvania, USA

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DNA demethylation of the promoter of the MEN1 gene in lung adenocarcinoma cells and inversely menin reduces the level of active Ras-GTP at least partly by preventing GRB2 and SOS1 from binding to Ras ( Wu et al. 2012 ); these studies suggest a

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0298
Volume/Issue:
Volume 24: Issue 10
Free access