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Maria Santa Rocca, Andrea Di Nisio, Arianna Marchiori, Marco Ghezzi, Giuseppe Opocher, Carlo Foresta, and Alberto Ferlin

to the oncogenesis of TGCT ( Stadler et al. 2012 , Edsgärd et al. 2013 ). E2F1 (UniprotKB: Q01094) is a member of the E2F family, acting as a transcription factor with high binding affinity for the retinoblastoma tumor suppressor (RB) protein

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Takako Araki, Ning-Ai Liu, Yukiko Tone, Daniel Cuevas-Ramos, Roy Heltsley, Masahide Tone, and Shlomo Melmed

differs from pituitary regulation and report an E2F1-mediated mechanism for hPOMC transcription. We also show that E2F1 antagonists markedly suppress hPOMC expression and paraneoplastic ACTH secretion in human-derived tumor primary cultures. Our

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Petteri Ahtiainen, Victoria Sharp, Susana B Rulli, Adolfo Rivero-Müller, Veronika Mamaeva, Matias Röyttä, and Ilpo Huhtaniemi

( Poel 1966 , Lamberts et al . 1985 ). Recent studies have elucidated the molecular pathogenesis of pituitary adenomas. Increased activation of the cyclin D1 (CCND1)/cyclin-dependent kinase 4 (CDK4)/retinoblastoma protein (RB)/transcription factor E2F1

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Dario Palmieri, Teresa Valentino, Ivana De Martino, Francesco Esposito, Paolo Cappabianca, Anne Wierinckx, Michela Vitiello, Gaetano Lombardi, Annamaria Colao, Jacqueline Trouillas, Giovanna Maria Pierantoni, Alfredo Fusco, and Monica Fedele

HMGA2 ( Fedele et al . 2002 , 2005 ). Our previous studies demonstrated that HMGA2 induces pituitary tumour development by enhancing E2F1 activity ( Fedele et al . 2006 ). Indeed, following the interaction with the retinoblastoma protein pRB, HMGA2

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Ivana De Martino, Rosa Visone, Dario Palmieri, Paolo Cappabianca, Paolo Chieffi, Floriana Forzati, Antonio Barbieri, Mogens Kruhoffer, Gaetano Lombardi, Alfredo Fusco, and Monica Fedele

HMGA2 in this human neoplasia ( Finelli et al. 2002 ). The mechanism by which HMGA2 is involved in pituitary tumorigenesis is on the ability of the HMGA2 to interfere with the pRB/E2F1 pathway. In fact, we have recently shown that HMGA2 interacts with

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Flavia R M Latini, Jefferson P Hemerly, Gisele Oler, Gregory J Riggins, and Janete M Cerutti

. Expression of p21 , E2F1 , MMP-1 and Ki67 by qPCR Expression analysis was performed at days 3 and 5. Total RNA isolation and cDNA synthesis were performed as described ( Cerutti et al . 2007 ). An aliquot of cDNA was used in 20 μl PCR containing SYBR

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Andrea Vecchione and Carlo M Croce

4 miR-29 7q32 DNA methylation Mcl-1 miR-34a 1p36 Regulation of cell cycle SIRT1 CDK4 miR-34b/c 11q23 Regulation of proliferation and adhesion-independent cell growth CDK6 miR-106b-25 7q22 Regulates E2F1 involved

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Raymond R Y Wong, Michael J Worley Jr, Tony K H Chung, and Yick Fu Wong

increased the level of E2F1 protein in OVCAR8 cells, reflecting a mechanism mediated by TGFβ that decreased E2F1 mRNA and protein level during growth inhibition. The increase in E2F1 level by MIS may result from a decrease in p130 (RBL2) level and reversal

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Phungern Khongthong, Antonia K Roseweir, and Joanne Edwards

-Rel activity, followed by proliferation and an invasive phenotype transformation of breast cancer. (B) Upon activation with PI3K, IKKα phosphorylates both ER and SRC3 to further increase their transcriptional activity and acetylates E2F1 to increase the

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Mathieu Lupien and Myles Brown

AR regulate the expression of genes central to breast and prostate cancer development, including CCND1 , E2F1 , Myc as well as TMPRSS2 , and PSA respectively ( Prall et al . 1998 , Balk et al . 2003 , Demichelis & Rubin 2007 , Stender et