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Zvi Laron Endocrinology and Diabetes Research Unit, Schneider Children’s Medical Center, Petah Tikva, Israel

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Haim Werner Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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of Laron syndrome (LS) patients, a prototypical case of congenital IGF-1 deficiency. The identification of novel GH–IGF-1 downstream targets reflects the key role of this axis in cancer as well as the complexity of the mechanisms responsible for

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0394
Volume/Issue:
Volume 30: Issue 9
Free access
Lena Lapkina-Gendler Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Itai Rotem Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Metsada Pasmanik-Chor Bioinformatics Unit, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

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David Gurwitz Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Yoran Institute for Human Genome Research, Tel Aviv University, Tel Aviv, Israel

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Rive Sarfstein Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Zvi Laron Endocrine and Diabetes Research Unit, Schneider Children’s Medical Center, Petah Tikva, Israel

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Haim Werner Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Yoran Institute for Human Genome Research, Tel Aviv University, Tel Aviv, Israel

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during postnatal life. Congenital IGF1 deficiency is characterized by low to undetectable serum IGF1 levels, but normal to elevated GH production. These conditions may result from the following: (1) GH-releasing hormone-receptor ( GHRH-R ) gene defect, (2

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0054
Volume/Issue:
Volume 23: Issue 5
Free access
Maura Fanti Longevity Institute, Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, California, USA

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Valter D Longo Longevity Institute, Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, California, USA

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compared with their normal siblings ( Ikeno et al. 2003 ). Moreover, GH -/- and GHR -/- mice (Laron Syndrome, LS), both display severe IGF-1 deficiency, smaller body size, in both length and weight ( Zhou et al. 1997 ), and reduced incidence of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-23-0048
Volume/Issue:
Volume 31: Issue 11
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Cesar Luiz Boguszewski Department of Internal Medicine, Endocrine Division (SEMPR), University Hospital, Federal University of Parana, Curitiba, Brazil

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Margaret Cristina da Silva Boguszewski Department of Pediatrics, Endocrine Division (SEMPR), University Hospital, Federal University of Parana, Curitiba, Brazil

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Wouter W de Herder Department of Internal Medicine, Sector of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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examples of human disorders associated with congenital isolated or combined GHD or GH resistance with severe IGF1 deficiency (Laron syndrome) have found lower incidences or even absence of cancer in these groups of patients ( Aguiar-Oliveira & Bartke 2019

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0400
Volume/Issue:
Volume 30: Issue 4
Free access
Maria Teresa Valenti Department of Medicine, Internal Medicine, Section D, University of Verona, Verona, Italy

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Monica Mottes Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

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Samuele Cheri Department of Medicine, Internal Medicine, Section D, University of Verona, Verona, Italy
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

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Michela Deiana Department of Medicine, Internal Medicine, Section D, University of Verona, Verona, Italy
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

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Valentina Micheletti Department of Medicine, Internal Medicine, Section D, University of Verona, Verona, Italy

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Elisa Cosaro Department of Medicine, Internal Medicine, Section D, University of Verona, Verona, Italy

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Maria Vittoria Davì Department of Medicine, Internal Medicine, Section D, University of Verona, Verona, Italy

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Giuseppe Francia Department of Medicine, Internal Medicine, Section D, University of Verona, Verona, Italy

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Luca Dalle Carbonare Department of Medicine, Internal Medicine, Section D, University of Verona, Verona, Italy

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symptoms, including osteoarticular manifestations: acromegaly is considered as a cause of secondary osteoporosis. The GH/IGF1 axis represents in fact a major signaling system, among others, for bone development and remodeling. It is known that GH/IGF1

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0523
Volume/Issue:
Volume 25: Issue 3
Free access
Rehan M Villani Institute for Molecular Bioscience, Department of Dermatology, University of Queensland, 360 Carmody Road, St Lucia, Brisbane, Queensland 4072, Australia
Institute for Molecular Bioscience, Department of Dermatology, University of Queensland, 360 Carmody Road, St Lucia, Brisbane, Queensland 4072, Australia

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Michael J Waters Institute for Molecular Bioscience, Department of Dermatology, University of Queensland, 360 Carmody Road, St Lucia, Brisbane, Queensland 4072, Australia

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Brandon J Wainwright Institute for Molecular Bioscience, Department of Dermatology, University of Queensland, 360 Carmody Road, St Lucia, Brisbane, Queensland 4072, Australia

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/lox mice are associated with systemic Igf1 deficiency. GH levels (A) do not differ between controls and K14-Cre:Ptch1 lox/lox mice and GH induces JAK2 (B) and STAT5 (C) in K14-Cre:Ptch1 lox/lox mice similar to controls. Igf hormone levels

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0307
Volume/Issue:
Volume 20: Issue 3
Free access
Jaime Guevara-Aguirre Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador
Instituto de Endocrinología IEMYR, Quito, Ecuador
Maastricht University, Maastricht, The Netherlands

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Gabriela Peña Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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William Acosta Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Gabriel Pazmiño Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Jannette Saavedra Instituto de Endocrinología IEMYR, Quito, Ecuador

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Lina Soto Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Daniela Lescano Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Alexandra Guevara Instituto de Endocrinología IEMYR, Quito, Ecuador

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Antonio W D Gavilanes Maastricht University, Maastricht, The Netherlands

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Research 17 54 – 57 . ( https://doi.org/10.1016/j.ghir.2006.10.007 ) Steuerman R Shevah O & Laron Z 2011 Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies . European Journal of Endocrinology 164

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0402
Volume/Issue:
Volume 30: Issue 10
Free access
Nikki A Ford Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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Nomeli P Nunez Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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Valerie B Holcomb Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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Stephen D Hursting Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA
Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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(in LC mice) partially mimics liver IGF1 deficiency on Met1 tumor growth, systemic IGF1 levels, tumoral Akt pathway signaling, and EMT and chemokine gene expression. In addition, the inhibitory effects of CR on tumor growth are repressed in LID mice

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0329
Volume/Issue:
Volume 20: Issue 1
Free access
Nicola M Bougen The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand
The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Michael Steiner The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Mikhail Pertziger The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Arindam Banerjee The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Severine E Brunet-Dunand The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Tao Zhu The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Peter E Lobie The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand
The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Jo K Perry The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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M Fairbairn LJ 2006 Radioprotective gene therapy through retroviral expression of manganese superoxide dismutase . Journal of Gene Medicine 8 557 – 565 . ( doi:10.1002/jgm.890 ). Steuerman R Shevah O Laron Z 2011 Congenital IGF1

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0042
Volume/Issue:
Volume 19: Issue 5
Free access
Verónica A Bahamondes Lorca Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
Departamento de Tecnología Médica, Facultad de Medicina, Universidad de Chile, Santiago, Chile

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Shiyong Wu Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA

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described as a critical regulator of the capacity to respond to DNA damage. The study showed that developmental GH–IGF-1 deficiency is characterized by resistance to damaging agents, such as γ-radiation, due to a very efficient DNA repair capacity. This

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-22-0371
Volume/Issue:
Volume 31: Issue 3
Restricted access