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Amanda Schech
Amanda Schech
Department of Pharmacology, Division of Biostatistics, Department of Medicine and Physiology, University of Maryland School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland, USA
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Stephen Yu
Stephen Yu
Department of Pharmacology, Division of Biostatistics, Department of Medicine and Physiology, University of Maryland School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland, USA
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Olga Goloubeva
Olga Goloubeva
Department of Pharmacology, Division of Biostatistics, Department of Medicine and Physiology, University of Maryland School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland, USA
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John McLenithan
John McLenithan
Department of Pharmacology, Division of Biostatistics, Department of Medicine and Physiology, University of Maryland School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland, USA
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Gauri Sabnis
Gauri Sabnis
Department of Pharmacology, Division of Biostatistics, Department of Medicine and Physiology, University of Maryland School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland, USA
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) quicker than the tumors in the lean mice. This suggests that obesity influences the response and resistance of tumors to AIs such as letrozole. Figure 7 Effect of HFSD on the growth of MCF-7Ca xenografts. Mice were fed HFS or LF diets for 6 weeks and then
Tiago Vieira Augusto
Tiago Vieira Augusto
UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
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Georgina Correia-da-Silva
Georgina Correia-da-Silva
UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
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Cecília M P Rodrigues
Cecília M P Rodrigues
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
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Natércia Teixeira
Natércia Teixeira
UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
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Cristina Amaral
Cristina Amaral
UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
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effect, through HER2 modulation, on LTLT-Ca cells and on Letrozole-resistant MCF-7Ca xenografts ( Sabnis et al . 2013 a , Schech et al . 2015 ). Anastrozole resistance Different mechanisms were described to be associated with anastrozole
Nicola Normanno
Nicola Normanno
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Massimo Di Maio
Massimo Di Maio
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Ermelinda De Maio
Ermelinda De Maio
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Antonella De Luca
Antonella De Luca
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Andrea de Matteis
Andrea de Matteis
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Antonio Giordano
Antonio Giordano
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Francesco Perrone
Francesco Perrone
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cells are treated with higher levels of estrogen. In agreement with these findings, treatment of MCF-7Ca xenografts with a combination of fulvestrant and letrozole resulted in tumor regression that was sustained for a significantly longer period as
