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U1149 – University Paris Diderot, Paris, France
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Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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U1149 – University Paris Diderot, Paris, France
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U1149 – University Paris Diderot, Paris, France
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Department of Digestive Oncology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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Department of Pathology, AP-HP, DHU UNITY, Bichat University Hospital, Paris, France
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O 6 -methylguanine-DNA methyltransferase (MGMT) function before TEM-based treatment ( Zhang et al. 2011 ). This suicide enzyme removes alkyl group from the O 6 position on guanine bases, one of the main sites of TEM-induced DNA damage. Without
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tumor cell death. The suicide enzyme O 6 -methylguanine DNA methyltransferase (MGMT) repairs DNA by removing the O 6 -alkylguanine adducts. High levels of MGMT expression contribute to chemoresistance by counteracting the therapeutic effect of alkylating
Centre of Research on Inflammation, INSERM U1149, Paris, France
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Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France
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Centre of Research on Inflammation, INSERM U1149, Paris, France
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Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France
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Centre of Research on Inflammation, INSERM U1149, Paris, France
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Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France
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validated for clinical practice. Over the last decade, an increasing number of publications have explored whether the tumor expression of O 6 -methylguanine-DNA methyltransferase (MGMT) could influence the efficacy of alkylating agents ( Koumarianou et al
Université de Paris, Centre de Recherche sur l’Inflammation, INSERM, Paris, France
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Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospital, Paris/Clichy, France
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Université de Paris, Centre de Recherche sur l’Inflammation, INSERM, Paris, France
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Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospital, Paris/Clichy, France
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Université de Paris, Centre de Recherche sur l’Inflammation, INSERM, Paris, France
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O-6-methylguanine-methyltransferase (MGMT) enzyme ( Koumarianou et al. 2015 , de Mestier et al. 2020 b ). In PanNET, high expression of MGMT seems to be associated with a lower response and shorter PFS under ALK ( Walter et al. 2015 , Cros
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methyltransferase (MGMT) acts as a repair mechanism to remove the methyl group from guanine bases and to therefore counteract the effects of temozolomide. MGMT is sometimes referred to as a suicide enzyme because in the process of removing the methyl group, the
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-repair events leads to apoptosis ( Sabharwal & Middleton 2006 ). The action of TMZ depends on its accumulation in the tumor and the capacity for O 6 -methylguanine-DNA methyltransferase (MGMT), present in the cells, to repair its effects ( Kaina et al . 2007
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GCB Graduate School Bern, Bern, Switzerland
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GCB Graduate School Bern, Bern, Switzerland
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shown in several genes ( VHL, cdkn2a (p16), RASSF1 , DAPK1 , TIMP3 , PAX5 , HIC1 , CADM1 , PYCARD , ESR1 , VHL , RARB , WT1 and MGMT ) ( House et al. 2003 , Schmitt et al. 2009 , Malpeli et al. 2011 , Schmitt et al. 2014
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regimens may deplete O 6-methylguanine DNA methyltransferase (MGMT), an important factor in cases of TMZ resistance and/or inhibit endothelial cell proliferation and formation of tumour vasculature via the so-called metronomic effect ( Tolcher et al
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UCL Cancer Institute, UCL, London, UK
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UCL Cancer Institute, UCL, London, UK
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that of Sorbye and coworkers, the majority of patients received platinum-based chemotherapy and Ki-67 may be a better predictor of response for this agent. The expression of the DNA repair enzyme O6-methylguanine DNA methyltransferase (MGMT) has also
Université Paris-Sud Orsay, Île-de-France, France
Gustave Roussy, Villejuif, France
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Gustave Roussy, Villejuif, France
UMR 8200 CNRS, Villejuif, France
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Gustave Roussy, Villejuif, France
UMR 8200 CNRS, Villejuif, France
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Université Paris-Sud Orsay, Île-de-France, France
Gustave Roussy, Villejuif, France
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PSL Research University, Paris, France
INSERM, U900, Paris, France
Mines Paris Tech, Fontainebleau, France
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Université Paris-Sud Orsay, Île-de-France, France
Gustave Roussy, Villejuif, France
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OGG1 Association of rs2296675 (MGMT) with DTC Individual radiation dose to the thyroid was reconstructed based on the residential history and dietary habits, and information on environmental contamination for each settlement