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Elena Valassi, Frédéric Castinetti, Amandine Ferriere, Stylianos Tsagarakis, Richard A Feelders, Romana T Netea-Maier, Michael Droste, Christian J Strasburger, Dominique Maiter, Darko Kastelan, Philippe Chanson, Susan M Webb, Frank Demtröder, Valdis Pirags, Olivier Chabre, Holger Franz, Alicia Santos, and Martin Reincke

, which has traditionally been defined as ‘Nelson’s syndrome’ (NS) ( Barnett et al. 1983 , Kasperlik-Zaluska et al. 1983 , Littley et al. 1990 , McCance et al. 1993 , Kemink et al. 1994 , Misra et al. 1994 , Jenkins et al. 1995

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Thomas Cuny, Caroline Zeiller, Martin Bidlingmaier, Céline Défilles, Catherine Roche, Marie-Pierre Blanchard, Marily Theodoropoulou, Thomas Graillon, Morgane Pertuit, Dominique Figarella-Branger, Alain Enjalbert, Thierry Brue, and Anne Barlier

( Iwama et al. 2014 ). In light of the so-called Nelson’s syndrome secondary to bilateral adrenalectomy and abolition of the cortisol-induced negative feedback, the issue concerning the role of PEG in promoting growth of a residual GH-secreting tumor

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Dorota Dworakowska and Ashley B Grossman

recurrence ( Webb et al. 2003 , Heaney 2011 , Jahangiri et al. 2013 , Mete et al. 2013 , Heaney 2014 , Xu et al. 2014 , Cooper 2015 ). Nelson’s syndrome (occurring after removal of cortisol-mediated negative feedback following bilateral