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Eric Y Lian, Sarah M Maritan, Jessica G Cockburn, Katayoon Kasaian, Mathieu J F Crupi, David Hurlbut, Steven J M Jones, Sam M Wiseman, and Lois M Mulligan

share the first 1063 residues but have 9 or 51 unique C-terminal amino acids, respectively ( Mulligan 2014 ). RET isoforms are generally co-expressed but have distinct molecular and functional properties. RET9 and RET51 differ in membrane localisation

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Tirtha K Das and Ross L Cagan

: genetic screens To model RET M918T (the RET isoform associated with MEN2B) Drosophila RET M955T was targeted to the developing eye, a well characterized epithelia in terms of cell–cell interactions and signal transduction ( Read et al . 2005 ). RET

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Maria Grazia Borrello, Antonella Aiello, Bernard Peissel, Maria Grazia Rizzetti, Piera Mondellini, Debora Degl'Innocenti, Veronica Catalano, Morena Gobbo, Paola Collini, Italia Bongarzone, Marco A Pierotti, Angela Greco, and Ettore Seregni

performed on pCDNA3 eukaryotic expression vector carrying the two RET isoforms ( RET9 or RET51 ) to obtain the following mutants: RET9 -K666E, RET51 -K666E, RET9 -G691S, RET51 -G691S, RET9 -K666E–G691S, and RET51 -K666E–G691S. To assess the quality

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Giovanni Vitale, Germano Gaudenzi, Luisa Circelli, Marco F Manzoni, Andrea Bassi, Niccolò Fioritti, Antongiulio Faggiano, Annamaria Colao, and on behalf of NIKE Group

Ret gene ( Table 1 ). Table 1 Genetically engineered mouse models of medullary thyroid cancer carrying RET mutations. RET mutation RET isoform Promoter Background strain Tumor phenotype Reference C634R RET9 Rat

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Francesca Carlomagno, Teresa Guida, Suresh Anaganti, Livia Provitera, Svend Kjaer, Neil Q McDonald, Anderson J Ryan, and Massimo Santoro

type . Japanese Journal of Cancer Research 90 1231 – 1237 . Vidal M Wells S Ryan A Cagan R 2005 ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid

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Donata Vitagliano, Valentina De Falco, Anna Tamburrino, Sabrina Coluzzi, Giancarlo Troncone, Gennaro Chiappetta, Fortunato Ciardiello, Giampaolo Tortora, James A Fagin, Anderson J Ryan, Francesca Carlomagno, and Massimo Santoro

clinical applications . Nature Clinical Practice. Oncology 5 521 – 530 doi:10.1038/ncponc1161 . Vidal M Wells S Ryan A Cagan R 2005 ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia

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Lois M Mulligan

Rekab AN Lian EY Wagner SM Antonescu CN Mulligan LM 2017 Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization . Journal of Cell Science 130 3282 – 3296 . ( ) 28794017

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Maria Domenica Castellone and Rosa Marina Melillo

2002 ). Three RET isoforms (RET9, RET43 and RET51) encoding for protein variants differing in the intracellular tyrosines involved in RET activation ( Tahira et al . 1990 , Lorenzo et al . 1995 , Matera et al . 2000 ) have been described. RET is

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Hugo Prazeres, Joana P Couto, Fernando Rodrigues, João Vinagre, Joana Torres, Vitor Trovisco, Teresa C Martins, Manuel Sobrinho-Simões, and Paula Soares

screening was performed in DNA obtained from peripheral blood leucocytes, by PCR amplification and direct Sanger sequencing of exons 8, 10, 11, and 13–16. Site-directed mutagenesis A pRcCMV vector expressing RET isoform 51 (i51) was mutated to generate the

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Lucieli Ceolin, Marta Amaro da Silveira Duval, Antônio Felippe Benini, Carla Vaz Ferreira, and Ana Luiza Maia

three RET isoforms, but the tyrosine residue 1096 is present only in the long (RET 51) isoform. RET is a receptor tyrosine kinase essential for the normal development and maturation of different tissues. Under normal conditions, RET is activated by a