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Guoliang Wang Department of Tumor and Immunology, Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health, Beijing, China

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Na Ren Department of Clinical Laboratory Center, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Shengcai Wang Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Xuexi Zhang Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Yanzhen Li Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Nian Sun Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Qiaoyin Liu Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Jie Zhang Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Wenqi Song Department of Clinical Laboratory Center, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Xin Ni Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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it more important to identify the risk factors for malignant transformation of thyroid nodules. Among various potential risk factors being evaluated, elevated serum TSH concentration has been reported by multiple studies to be associated with the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0508
Volume/Issue:
Volume 28: Issue 4
Restricted access
Tae-Hwan Kim Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

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Mi Yeon Lee Division of Biostatistics, Department of R&D Management, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

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Sung Min Jin Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

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Sang Hyuk Lee Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

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. 2006 , Wartofsky 2010 ). Recently, higher height and body weight were also reported as risk factors for thyroid cancer ( Kitahara et al. 2011 ). Abnormal thyroid hormones and TSH may be associated with carcinogenesis. Thyroid dysfunction can

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0094
Volume/Issue:
Volume 29: Issue 12
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Hannah Nieto Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Kristien Boelaert Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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). Most international guidelines recommend the use of a combination of diagnostic tools, including measurement of thyroid-stimulating hormone (TSH) to assess functional thyroid status, high resolution ultrasonography (US) scanning to assess the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0328
Volume/Issue:
Volume 23: Issue 11
Free access
Milena Simões Peixoto Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Andressa de Vasconcelos e Souza Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Iris Soares Andrade Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Carolina de Carvalho el Giusbi Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Caroline Coelho Faria Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Fabio Hecht Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Leandro Miranda-Alves Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Andrea Claudia Freitas Ferreira Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
NUMPEX, Duque de Caxias Campus, Universidade Federal do Rio de Janeiro, Brazil

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Denise Pires Carvalho Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Rodrigo S Fortunato Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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metastasis. It is important to note that serum thyroid-stimulating hormone (TSH) is generally high in the hypothyroid state, but its specific role in breast was not elucidated. Although the influence of thyroid dysfunctions on breast cancer promotion and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0010
Volume/Issue:
Volume 28: Issue 7
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Kristien Boelaert School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, IBR Building 2nd Floor, Edgbaston, Birmingham B15 2TT, UK

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). More recently, a number of studies have suggested that higher concentrations of TSH, even within the normal range, are associated with a subsequent diagnosis of thyroid cancer in patients presenting with thyroid nodules ( Table 1 ; Boelaert et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0150
Volume/Issue:
Volume 16: Issue 4
Free access
Christopher W Rowe Department of Endocrinology, John Hunter Hospital, Newcastle, Australia
School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Jonathan W Paul School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Craig Gedye Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Medical Oncology, Calvary Mater Newcastle, Waratah, Australia
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia

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Jorge M Tolosa School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Cino Bendinelli School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Department of Surgery, John Hunter Hospital, Newcastle, Australia

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Shaun McGrath Department of Endocrinology, John Hunter Hospital, Newcastle, Australia
School of Medicine and Public Health, University of Newcastle, Newcastle, Australia

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Roger Smith Department of Endocrinology, John Hunter Hospital, Newcastle, Australia
School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Introduction The thyroid-stimulating hormone (TSH) receptor (TSHR) is a surface glycoprotein receptor, part of the leucine-rich repeat subfamily of G-protein-coupled receptors (LGR). It has been described as the ‘master switch’ in regulating

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0010
Volume/Issue:
Volume 24: Issue 6
Free access
Jonathan M Fussey Head and Neck Surgery, Royal Devon and Exeter Hospital, Exeter, Devon, UK

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Robin N Beaumont Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, UK

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Andrew R Wood Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, UK

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Bijay Vaidya Endocrinology, Royal Devon and Exeter Hospital, Exeter, Devon, UK

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Joel Smith Head and Neck Surgery, Royal Devon and Exeter Hospital, Exeter, Devon, UK

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Jessica Tyrrell Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, Devon, UK

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Introduction Several studies, including a large meta-analysis, have reported an observational association between raised serum thyroid-stimulating hormone (TSH) and thyroid cancer ( McLeod et al. 2012 ); however, there is significant

Article Type:
Letter
DOI:
https://doi.org/10.1530/ERC-21-0156
Volume/Issue:
Volume 28: Issue 9
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Hye In Kim Division of Endocrinology and Metabolism, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea

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Meihua Jin Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Nak Gyeong Ko Department of Research Support, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea

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Young Lyun Oh Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

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Jung Hee Shin Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

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Jung-Han Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

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Jee Soo Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

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Min Ji Jeon Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Tae Yong Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Sun Wook Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

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Won Bae Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Jae Hoon Chung Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

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Young Kee Shong Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Gu Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Tae Hyuk Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

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), some US features such as upper pole location ( Ito et al. 2004 , Jeon et al. 2017 ) or microcalcification ( Jeon et al. 2017 ), and high level of thyroid-stimulating hormone (TSH) ( Sugitani et al. 2014 , Kim et al. 2018 ). Among them, TSH

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0403
Volume/Issue:
Volume 29: Issue 4
Restricted access
Jonathan M Fussey Head and Neck Surgery, Royal Devon and Exeter Hospital, Exeter, UK

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Robin N Beaumont Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK

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Andrew R Wood Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK

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Bijay Vaidya Endocrinology, Royal Devon and Exeter Hospital, Exeter, UK

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Joel Smith Head and Neck Surgery, Royal Devon and Exeter Hospital, Exeter, UK

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Jessica Tyrrell Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK

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biopsy, thyroid function tests including serum thyroid-stimulating hormone (TSH) level are recommended in the investigation of a thyroid nodule ( Perros et al. 2014 , Haugen et al. 2016 ). The role of serum TSH testing is primarily to identify

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0067
Volume/Issue:
Volume 27: Issue 10
Open access
E Fiore Department of Endocrinology, Section of Pathology, Section of Cytopathology, Department of Surgery

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T Rago Department of Endocrinology, Section of Pathology, Section of Cytopathology, Department of Surgery

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M A Provenzale Department of Endocrinology, Section of Pathology, Section of Cytopathology, Department of Surgery

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M Scutari Department of Endocrinology, Section of Pathology, Section of Cytopathology, Department of Surgery

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C Ugolini Department of Endocrinology, Section of Pathology, Section of Cytopathology, Department of Surgery

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F Basolo Department of Endocrinology, Section of Pathology, Section of Cytopathology, Department of Surgery

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G Di Coscio Department of Endocrinology, Section of Pathology, Section of Cytopathology, Department of Surgery

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P Miccoli Department of Endocrinology, Section of Pathology, Section of Cytopathology, Department of Surgery

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L Grasso Department of Endocrinology, Section of Pathology, Section of Cytopathology, Department of Surgery

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A Pinchera Department of Endocrinology, Section of Pathology, Section of Cytopathology, Department of Surgery

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P Vitti Department of Endocrinology, Section of Pathology, Section of Cytopathology, Department of Surgery

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Introduction Thyroid-stimulating hormone (TSH) is the main regulator of thyroid function and is involved in the secretion of thyroid hormones, maintenance of thyroid-specific gene expression (differentiation), and thyroid cell proliferation

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0251
Volume/Issue:
Volume 17: Issue 1
Free access