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María Jesús Larriba
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Noelia Valle
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Héctor G Pálmer
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Paloma Ordóñez-Morán
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Silvia Álvarez-Díaz
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Karl-Friedrich Becker
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Carlos Gamallo
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Antonio García de Herreros
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José Manuel González-Sancho
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Alberto Muñoz
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analogues with reduced calcemic properties are being used in pre-clinical studies and clinical trials against colon cancer and other neoplasias. Colon cancer is one of the most frequent neoplasias and a major health problem worldwide. Wnt/β-catenin

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-06-0028
Volume/Issue:
Volume 14: Issue 1
Free access
Sayantani Sarkar
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Chandan Mandal
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Rajender Sangwan Cancer Biology and Inflammatory Disorder Division, Bio-Processing Unit, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, 4, Raja S.C. Mallick Road, Kolkata 700032, West Bengal, India

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Chitra Mandal
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Introduction Aberrant Wnt/β-catenin signaling is often observed in various cancers ( Polakis 2000 , Moon et al . 2002 , Lustig & Behrens 2003 ). β-catenin is a ubiquitously expressed protein with multiple functions. Initially, this protein was

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Research Article
DOI:
https://doi.org/10.1530/ERC-13-0315
Volume/Issue:
Volume 21: Issue 1
Free access
Yi Li Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA
Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Yichun Zheng Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA
Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Koji Izumi Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Hitoshi Ishiguro Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Bo Ye Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Faqian Li Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Hiroshi Miyamoto Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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mechanism by which AR signaling modulates bladder cancer progression remains poorly understood. The canonical Wnt/β-catenin signaling pathway has been shown to play a pivotal role in normal cell growth and differentiation, embryonic development, and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0328
Volume/Issue:
Volume 20: Issue 3
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Cristina L Ronchi
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Silviu Sbiera Endocrine and Diabetes Unit, Central Laboratory, Institute of Pathology, Comprehensive Cancer Center Mainfranken, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Oberrduerrbacher-Strasse 6, 97080 Wuerzburg, Germany

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Barbara Altieri
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Sonja Steinhauer
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Vanessa Wild Endocrine and Diabetes Unit, Central Laboratory, Institute of Pathology, Comprehensive Cancer Center Mainfranken, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Oberrduerrbacher-Strasse 6, 97080 Wuerzburg, Germany
Endocrine and Diabetes Unit, Central Laboratory, Institute of Pathology, Comprehensive Cancer Center Mainfranken, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Oberrduerrbacher-Strasse 6, 97080 Wuerzburg, Germany

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Michaela Bekteshi
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Matthias Kroiss Endocrine and Diabetes Unit, Central Laboratory, Institute of Pathology, Comprehensive Cancer Center Mainfranken, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Oberrduerrbacher-Strasse 6, 97080 Wuerzburg, Germany

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Martin Fassnacht
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Bruno Allolio
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study that employed SNP array profiling in adrenocortical tumors (ACTs), we identified the Notch1 signaling pathway as being the most frequently altered pathway in both ACAs and ACCs, followed by alterations in Wnt/β-catenin signaling ( Ronchi et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0163
Volume/Issue:
Volume 22: Issue 4
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F Cetani Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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E Pardi Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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C Banti Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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P Collecchi Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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P Viacava Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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S Borsari Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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G Fanelli Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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A G Naccarato Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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F Saponaro Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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P Berti Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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P Miccoli Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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A Pinchera Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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C Marcocci Department of Endocrinology and Metabolism, Department of Oncology, Department of Surgery

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). HRPT2 encodes a protein of 531 amino acids called parafibromin. Parafibromin is a tumor suppressor protein and has recently been linked to Wnt/β catenin pathway ( Mosimann et al . 2006 ). Activation of the Wnt/β-catenin pathway is involved in a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0147
Volume/Issue:
Volume 17: Issue 1
Free access
Luming Wu Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Jing Xie Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Yan Qi Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Tingwei Su Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Lei Jiang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Weiwei Zhou Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Yiran Jiang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Cui Zhang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Xu Zhong Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Yanan Cao Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Weiqing Wang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China

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alterations of exon 3 (p.KAAV19fs, p.45_48SLSG>C, and p.APSLSGK43del) were found in the other tumors. Moreover, none of these genetic alterations were observed in DNA of blood samples, demonstrating their somatic origin. These findings may further confirm Wnt/β-catenin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0410
Volume/Issue:
Volume 29: Issue 9
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Jessica Svedlund Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, Entrance 70, 3 tr, SE-751 85 Uppsala, Sweden

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Elham Barazeghi Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, Entrance 70, 3 tr, SE-751 85 Uppsala, Sweden

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Peter Stålberg Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, Entrance 70, 3 tr, SE-751 85 Uppsala, Sweden

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Per Hellman Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, Entrance 70, 3 tr, SE-751 85 Uppsala, Sweden

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Göran Åkerström Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, Entrance 70, 3 tr, SE-751 85 Uppsala, Sweden

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Peyman Björklund Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, Entrance 70, 3 tr, SE-751 85 Uppsala, Sweden

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Gunnar Westin Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, Entrance 70, 3 tr, SE-751 85 Uppsala, Sweden

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constitutes a target gene for the Wnt/β-catenin signaling pathway and in the absence of gene translocation, overexpression may in part be explained by pathway activation through aberrant accumulation of transcriptionally active (nonphosphorylated) β-catenin in

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Research Article
DOI:
https://doi.org/10.1530/ERC-13-0497
Volume/Issue:
Volume 21: Issue 2
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Julie Le Mestre Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France

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Michaël Thomas Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France

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Céline Duparc Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France

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Pierre Val CNRS, UMR 6293, GReD, Inserm U1103, Université Clermont Auvergne, Clermont-Ferrand, France

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Clémence Bures Department of Diabetes, Endocrinology and Metabolic Diseases, Groupe Hospitalier du Havre, Montivilliers, France

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Jean-Jacques Tuech Department of Digestive Surgery, Rouen University Hospital, Rouen, France

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Jean-Christophe Sabourin Department of Pathology, Rouen University Hospital, Rouen, France
Centre for Biological Resources, Rouen University Hospital, Rouen, France

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Stéphanie Baert-Desurmont Department of Genetics, Rouen University Hospital, Rouen, France

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Hervé Lefebvre Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France
Centre for Biological Resources, Rouen University Hospital, Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Rouen University Hospital, Rouen, France
Clinical Investigation Centre, INSERM, CIC1404, Rouen University Hospital, Rouen, France

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Estelle Louiset Normandie Univ., UNIROUEN, INSERM, U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen, France

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) (C). Data were analyzed by using Mann–Whitney U test. ** P < 0.01. Discussion It is well established that activation of the Wnt/β-catenin pathway is present in the majority of adrenocortical tumors, which on the other hand

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0298
Volume/Issue:
Volume 29: Issue 3
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André Wendindondé Nana PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei, Taiwan

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Yu-Tang Chin PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan

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Chi-Yu Lin Center for Teeth Bank and Dental Stem Cell Technology and School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan

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Yih Ho School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan

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James A Bennett Center for Immunology and Microbial Diseases, Albany Medical College, Albany, New York, USA

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Ya-Jung Shih Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan

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Yi-Ru Chen Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan

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Chun A Changou PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei, Taiwan
Integrated Laboratory, Center of Translational Medicine, Core Facility, Taipei Medical University, Taipei, Taiwan

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Jens Z Pedersen Department of Biology, University Tor Vergata, Rome, Italy

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Sandra Incerpi Department of Sciences, University Roma Tre, Rome, Italy

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Leroy F Liu Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan

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Jacqueline Whang-Peng Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan

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Earl Fu Department of Dentistry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan

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Wen-Shan Li Laboratory of Chemical Biology and Medicinal Chemistry, Institute of Chemistry, Academia Sinica, Taipei, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University, Taipei, Taiwan

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Shaker A Mousa Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York, USA

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Hung-Yun Lin PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan
Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York, USA
Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan

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Paul J Davis Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York, USA
Department of Medicine, Albany Medical College, Albany, New York, USA

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of relapse, which often leads to patients’ death. Novel therapeutic approaches are needed for this disease. The molecular pathogenesis of colon cancer encompasses the activation of several oncogenic signaling pathways, including the Wnt/β-catenin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0450
Volume/Issue:
Volume 25: Issue 3
Free access
Bruno Ragazzon Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France

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Guillaume Assié Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France

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Jérôme Bertherat Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France

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. 2001 ). Wnt/β-catenin pathway activation occurs more often in the poor prognostic subgroup of ACCs A majority of ACCs show a β-catenin nuclear delocalization in immunohistochemistry. However, in a subgroup of ACCs (approximately one quarter of cases

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-10-0220
Volume/Issue:
Volume 18: Issue 2
Free access