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Enzo Lalli and Michaela Luconi

in several types of endocrine cancers through a variety of mechanisms ( Lima et al . 2017 ). Metastasis in adrenocortical carcinoma (ACC): do paradigms apply? ACC is a rare endocrine malignancy with a high risk of relapse and

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S G Creemers, P M van Koetsveld, F J van Kemenade, T G Papathomas, G J H Franssen, F Dogan, E M W Eekhoff, P van der Valk, W W de Herder, J A M J L Janssen, R A Feelders, and L J Hofland

Introduction Adrenocortical carcinoma (ACC) is a rare malignancy, with an estimated incidence of 0.7–2.0 cases per million population each year ( Kebebew et al . 2006 , Golden et al . 2009 , Fassnacht et al . 2013 , Kerkhofs et al

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Ziwei Zhang, Menglian Li, Jianjun Wang, Mengsi Liu, Huan Chen, Yuan Lou, Yijie Wang, Qi Sun, Dalong Zhu, Ping Li, and Yan Bi

Introduction Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy with an annual incidence of 0.7–2.0 cases per million population ( Crona & Beuschlein 2019 ). ACC has a dismal prognosis, with a 5-year survival ranging

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Michaela Kuhlen, Pascal Mier, Marina Kunstreich, Lienhard Lessel, Dominik Schneider, Ines Brecht, Denis M Schewe, Michael C Frühwald, Peter Vorwerk, and Antje Redlich

Introduction Adrenocortical carcinomas (ACC) in children and adolescents are rare endocrine tumours with highly aggressive behaviour and dismal prognosis. The only curative treatment option is complete surgical tumour removal, while the role

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Isobel C Mouat, Kei Omata, Andrew S McDaniel, Namita G Hattangady, Debnita Talapatra, Andi K Cani, Daniel H Hovelson, Scott A Tomlins, William E Rainey, Gary D Hammer, Thomas J Giordano, and Tobias Else

with PA have a benign adrenal adenoma or bilateral hyperplasia. Adrenocortical carcinoma (ACC), however, is a very rare cause of increased aldosterone levels, and a recent literature review identified only 58 reported patients ( Seccia et al . 2005

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Linus Haberbosch, Lukas Maurer, Arvid Sandforth, Charlotte Wernicke, Joachim Spranger, Knut Mai, and Reiner Jumpertz von Schwartzenberg

Introduction Adrenocortical carcinoma (ACC) is a rare endocrine tumor characterized by high recurrence rates and often-fatal prognosis. The overall 5-year survival of patients undergoing tumor surgery is believed to be less than 40

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Yunhui Cheng, Raili Emilia Kerppola, and Tom Klaus Kerppola

order to develop such compounds for therapeutic use, it is essential to determine their efficacy in cell and animal models of cancer and to characterize their molecular mechanisms of action. Adrenocortical carcinoma (ACC) is an aggressive disease with

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Meenu Jain, Lisa Zhang, Mei He, Ya-Qin Zhang, Min Shen, and Electron Kebebew

Introduction Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy of the adrenal cortex ( Favia et al . 1995 , Wajchenberg et al . 2000 , Icard et al . 2001 , Bilimoria et al . 2008 ). Prognosis is poor in patients with locally

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Constanze Hantel, Sara Jung, Thomas Mussack, Martin Reincke, and Felix Beuschlein

Introduction Adrenocortical carcinoma (ACC) represents a rare but highly malignant tumor entity. In a large proportion of cases, the high growth rate of this endocrine neoplasm results in late diagnosis not amendable to surgical resection. However

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Peter M van Koetsveld, Giovanni Vitale, Richard A Feelders, Marlijn Waaijers, Diana M Sprij-Mooij, Ronald R de Krijger, Ernst-Jan M Speel, Johannes Hofland, Steven W J Lamberts, Wouter W de Herder, and Leo J Hofland

Introduction Adrenocortical carcinoma (ACC) is a rare but highly malignant endocrine tumor. Surgery is the primary choice of treatment but recurrence rates after surgery are high ( Schteingart et al . 2005 , Fassnacht et al . 2011 ). In case of