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Liyan Zhou Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Guiying Bai Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yue Song Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xiaohui Liu Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xiaoqing Li Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yilin Deng Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yiran Si Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yehui Shi Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Hongli Li Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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GADD45α-mediated promoter demethylation. These results revealed that commercial AGEs can partially represent the role of endogenous AGEs in this study. Furthermore, the term AGEs applies to a broad range of advanced glycation end products. The effect of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0330
Volume/Issue:
Volume 31: Issue 9
Restricted access
Xilin Yang Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Ying Wang Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Andrea O Y Luk Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Wing Yee So Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Ronald C W Ma Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Alice P S Kong Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Gang Xu Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Juliana C N Chan Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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of advanced glycation end products (AGEs), which have been implicated in development of liver disease ( Hyogo & Yamagishi 2008 ). Further experimental studies are needed to study the effects of AGEs on promoting HBV-associated HCC risk in diabetes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0290
Volume/Issue:
Volume 20: Issue 2
Free access
María Gutiérrez-Salmerón Area of Physiology, Area of Physiology, Faculty of Health Sciences, University Rey Juan Carlos, Alcorcón, Madrid, Spain

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Silvia Rocío Lucena Area of Physiology, Area of Physiology, Faculty of Health Sciences, University Rey Juan Carlos, Alcorcón, Madrid, Spain

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Ana Chocarro-Calvo Area of Physiology, Area of Physiology, Faculty of Health Sciences, University Rey Juan Carlos, Alcorcón, Madrid, Spain

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José Manuel García-Martínez Area of Physiology, Area of Physiology, Faculty of Health Sciences, University Rey Juan Carlos, Alcorcón, Madrid, Spain

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Rosa M Martín Orozco Area of Physiology, Area of Physiology, Faculty of Health Sciences, University Rey Juan Carlos, Alcorcón, Madrid, Spain

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Custodia García-Jiménez Area of Physiology, Area of Physiology, Faculty of Health Sciences, University Rey Juan Carlos, Alcorcón, Madrid, Spain

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endothelial dysfunction. These factors cooperate and contribute to CRC development through decreased immune surveillance, cell transformation, metastasis and angiogenesis. AGEs, advanced glycation end products; CRC, colorectal cancer; T2D, type 2 diabetes; ROS

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0315
Volume/Issue:
Volume 28: Issue 6
Free access
Jaime Guevara-Aguirre Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador
Instituto de Endocrinología IEMYR, Quito, Ecuador
Maastricht University, Maastricht, The Netherlands

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Gabriela Peña Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Gabriel Pazmiño Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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William Acosta Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Jannette Saavedra Instituto de Endocrinología IEMYR, Quito, Ecuador

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Daniela Lescano Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Alexandra Guevara Instituto de Endocrinología IEMYR, Quito, Ecuador

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Antonio W D Gavilanes Maastricht University, Maastricht, The Netherlands

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-lasting excess glucose and insulin serum levels result in the generation of advanced glycation end products that distort bodily proteins, hence originating permanent and usually irreversible tissue damage ( Gallagher & LeRoith 2015 ). Because of their higher

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0389
Volume/Issue:
Volume 30: Issue 6
Free access
Jill I Murray Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5

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Nathan R West Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5

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Leigh C Murphy Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5

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Peter H Watson Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5
Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5
Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5

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by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15 . Journal of Immunology 181 1499 – 1506 . ( doi:10.4049/jimmunol.181.2.1499 ). Wolk K Witte E Wallace

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0096
Volume/Issue:
Volume 22: Issue 1
Free access
Shyh-Han Tan Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, BLSB 309, Philadelphia, Pennsylvania 19107, USA

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Marja T Nevalainen Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, BLSB 309, Philadelphia, Pennsylvania 19107, USA

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proteins on androgen-mediated gene activation in prostate cancer cells . Oncogene 20 3880 – 3887 . Guh JY Huang JS Chen HC Hung WC Lai YH Chuang LY 2001 Advanced glycation end product-induced proliferation in NRK-49F cells is dependent on the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0013
Volume/Issue:
Volume 15: Issue 2
Free access
Robert C Mould Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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Jacob P van Vloten Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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Amanda W K AuYeung Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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Khalil Karimi Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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Byram W Bridle Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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signals through TLR4, TLR9 and the receptor for advanced glycation end-products (RAGE) to promote further maturation of DCs ( Kang et al. 2013 ). However, the molecular translocation and signaling mechanisms that surround HMGB1 in ICD are complex and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0316
Volume/Issue:
Volume 24: Issue 12
Free access